2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. CA-170

CA-170 

Cat. No.: HY-101093 Purity: 99.39%
COA Handling Instructions

PD-1-IN-1 est un inhibiteur de la mort cellulaire programmée-1 (PD-1) extrait du brevet WO2015033299A1, exemple de composé 4. PD-1-IN-1 peut être utilisé comme modulateur immunitaire.

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes.

For research use only. We do not sell to patients.

CA-170 Chemical Structure

CA-170 Chemical Structure

CAS No. : 1673534-76-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 333 In-stock
Solution
10 mM * 1 mL in DMSO USD 333 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 720 In-stock
25 mg USD 1440 In-stock
50 mg USD 2280 In-stock
100 mg USD 3120 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CA-170:

CA-170 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CA-170

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes[1][2].

IC50 & Target

PD-1[1]
In Vitro

CA-170 exhibits potent functional activity in rescuing T-cell proliferation and effector functions, while showing selectivity against other immune checkpoint proteins as well as in a broad panel of receptors and enzymes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CA-170 Related Antibodies
Molecular Weight

360.32

Appearance

Solid

Formula

C12H20N6O7
CAS No.
SMILES

C[C@@H](O)[C@@H](C(O)=O)NC(N[C@H](C1=NC([C@@H](N)CO)=NO1)CC(N)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 28.5 mg/mL (79.10 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7753 mL 13.8766 mL 27.7531 mL
5 mM 0.5551 mL 2.7753 mL 5.5506 mL
10 mM 0.2775 mL 1.3877 mL 2.7753 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  1% DMSO    99% Saline

    Solubility: ≥ 0.5 mg/mL (1.39 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.39%

COA (252 KB) HNMR (199 KB) RP-HPLC (206 KB)

Handling Instructions (2659 KB)
References
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CA-170 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CA-1701673534-76-3CA170CA 170PD-1/PD-L1PD-1/Programmed death-ligand 1interfaceproliferationimmunecheckpointTcellsInhibitorinhibitorinhibit

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