1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. CA-170

CA-170 

Cat. No.: HY-101093 Purity: 96.26%
Handling Instructions

PD-1-IN-1 est un inhibiteur de la mort cellulaire programmée-1 (PD-1) extrait du brevet WO2015033299A1, exemple de composé 4. PD-1-IN-1 peut être utilisé comme modulateur immunitaire.

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes.

For research use only. We do not sell to patients.

CA-170 Chemical Structure

CA-170 Chemical Structure

CAS No. : 1673534-76-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 333 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 333 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 720 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3120 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CA-170:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CA-170

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes[1][2].

IC50 & Target

PD-1[1]

In Vitro

CA-170 exhibits potent functional activity in rescuing T-cell proliferation and effector functions, while showing selectivity against other immune checkpoint proteins as well as in a broad panel of receptors and enzymes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.32

Formula

C12H20N6O7

CAS No.
SMILES

C[[email protected]@H](O)[[email protected]@H](C(O)=O)NC(N[[email protected]](C1=NC([[email protected]@H](N)CO)=NO1)CC(N)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 28.5 mg/mL (79.10 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7753 mL 13.8766 mL 27.7531 mL
5 mM 0.5551 mL 2.7753 mL 5.5506 mL
10 mM 0.2775 mL 1.3877 mL 2.7753 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  1% DMSO    99% saline

    Solubility: ≥ 0.5 mg/mL (1.39 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 96.26%

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Product Name:
CA-170
Cat. No.:
HY-101093
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