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  5. Lappaconitine hydrobromide

Lappaconitine hydrobromide (Synonyms: Allapinine)

Cat. No.: HY-N0118 Purity: ≥95.0%
Handling Instructions

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias.

For research use only. We do not sell to patients.

Lappaconitine hydrobromide Chemical Structure

Lappaconitine hydrobromide Chemical Structure

CAS No. : 97792-45-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 246 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Lappaconitine hydrobromide:

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Description

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias. IC50 value: Target: A natural product for anti-cardiac arrhythmias In vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day [3].

Clinical Trial
Molecular Weight

665.61

Formula

C32H45BrN2O8

CAS No.
SMILES

CO[[email protected]@H]1C(C(N(CC)C2)C3C4)([[email protected]@](C[[email protected]@]5([H])[[email protected]@H]6OC)([H])[[email protected]@]6(O)[[email protected]@]3(C[[email protected]@H]5OC)O)[[email protected]@]4([H])[[email protected]@]2(OC(C(C=CC=C7)=C7NC(C)=O)=O)CC1.Br

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (75.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5024 mL 7.5119 mL 15.0238 mL
5 mM 0.3005 mL 1.5024 mL 3.0048 mL
10 mM 0.1502 mL 0.7512 mL 1.5024 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.76 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Lappaconitine hydrobromide
Cat. No.:
HY-N0118
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