1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. Lappaconitine

Lappaconitine (Synonyms: (+)-Lappaconitine)

Cat. No.: HY-N0383
Handling Instructions

Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as analgesic principle.

For research use only. We do not sell to patients.

Lappaconitine Chemical Structure

Lappaconitine Chemical Structure

CAS No. : 32854-75-4

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10 mg USD 54 Get quote
50 mg USD 120 Get quote
100 mg USD 168 Get quote

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Description

Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as analgesic principle. IC50 value: Target: In vitro: In vivo: Lappaconitine was characterized as analgesic principle by our laboratory. The results suggest that lappaconitine can produce analgesia, possibly through a decrease in cellular calcium availability and PAG may be involved in the Ca2+ antagonistic effect on lappaconitine analgesia [1]. Changes in lappaconitine levels in blood, brain and spinal cord following subcutaneous (s.c.) injection were correlated with the analgesic activity at intervals up to 90 minutes after injection. The equianalgesic doses of lappaconitine (ED50 by the s.c. route and additive ED50 by the i.c.v. plus i.t. route) gave closely similar concentrations of the drug in brain and spinal cord. These results indicate that a simultaneous action of lappaconitine on supraspinal and spinal sites is likely to be important for the analgesia produced by systemically administered lappaconitine [2].

Clinical Trial
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (53.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7103 mL 8.5514 mL 17.1028 mL
5 mM 0.3421 mL 1.7103 mL 3.4206 mL
10 mM 0.1710 mL 0.8551 mL 1.7103 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

584.70

Formula

C₃₂H₄₄N₂O₈

CAS No.

32854-75-4

SMILES

CO[[email protected]@H]1C(C(N(CC)C2)C3C4)([[email protected]@](C[[email protected]@]5([H])[[email protected]@H]6OC)([H])[[email protected]@]6(O)[[email protected]@]3(C[[email protected]@H]5OC)O)[[email protected]@]4([H])[[email protected]@]2(OC(C(C=CC=C7)=C7NC(C)=O)=O)CC1

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Product Name:
Lappaconitine
Cat. No.:
HY-N0383
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Lappaconitine

Cat. No.: HY-N0383