1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

Lasmiditan hydrochloride (Synonyms: LY 573144 hydrochloride; COL-144 hydrochloride)

Cat. No.: HY-14861A Purity: 99.89%
Handling Instructions

Lasmiditan hydrochloride is a high-affinity, highly selective 5-HT1F receptor agonist (Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively.

For research use only. We do not sell to patients.

Lasmiditan hydrochloride Chemical Structure

Lasmiditan hydrochloride Chemical Structure

CAS No. : 613677-28-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 131 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
2 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1560 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Lasmiditan hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Lasmiditan hydrochloride is a high-affinity, highly selective 5-HT1F receptor agonist (Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. IC50 value: 2.1 nM (Ki, 5-HT1F); >1000 nM (Ki, 5-HT1B/5-HT1D) [1] Target: 5-HT1F receptor in vitro: In vitro binding studies Lasmiditan showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor, compared with K(i) values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively, a selectivity ratio greater than 470-fold. Lasmiditan show higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370. Unlike the 5-HT(1B/1D) receptor agonist sumatriptan, lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 μM. in vivo: In two rodent models of migraine, oral administration of lasmiditan potently inhibited markers associated with electrical stimulation of the trigeminal ganglion (dural plasma protein extravasation, and induction of the immediate early gene c-Fos in the trigeminal nucleus caudalis).

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4165 mL 12.0825 mL 24.1651 mL
5 mM 0.4833 mL 2.4165 mL 4.8330 mL
10 mM 0.2417 mL 1.2083 mL 2.4165 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

413.82

Formula

C₁₉H₁₉ClF₃N₃O₂

CAS No.

613677-28-4

SMILES

O=C(NC1=NC(C(C2CCN(C)CC2)=O)=CC=C1)C3=C(F)C=C(F)C=C3F.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 28 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Lasmiditan hydrochloride
Cat. No.:
HY-14861A
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