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MMAD hydrochloride

HY-79105

(Demethyldolastatin 10 hydrochloride; Monomethylauristatin D hydrochloride; Monomethyl Dolastatin 10 hydrochloride)

MMAD hydrochloride

MMAD hydrochloride Chemical Structure

Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $799 In-stock
10 mg $726 In-stock
50 mg $1938 In-stock
100 mg $3230 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €783 In-stock
10 mg €711 In-stock
50 mg €1899 In-stock
100 mg €3165 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: MMAD hydrochloride
Cat. No.: HY-79105

MMAD hydrochloride Data Sheet

  • View current batch:

    Purity: 99.80% ee.:99.00%

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    DataSheet

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    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of MMAD hydrochloride

Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
IC50 value:
Target: Tubulin; ADCs toxin
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).
 

Chemical Information

M.Wt 807.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₁H₆₇ClN₆O₆S
CAS No 173441-26-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.2383 mL 6.1917 mL 12.3834 mL
5 mM 0.2477 mL 1.2383 mL 2.4767 mL
10 mM 0.1238 mL 0.6192 mL 1.2383 mL

References on MMAD hydrochloride

Other Forms

  • MMAD

    CAS No.: 203849-91-6 In-stock

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