1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

MMAD hydrochloride (Synonyms: Demethyldolastatin 10 hydrochloride; Monomethylauristatin D hydrochloride; Monomethyl Dolastatin 10 hydrochloride)

Cat. No.: HY-79105
Handling Instructions

Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

For research use only. We do not sell to patients.
MMAD hydrochloride Chemical Structure

MMAD hydrochloride Chemical Structure

CAS No. : 173441-26-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $799 In-stock
10 mg $726 In-stock
50 mg $1938 In-stock
100 mg $3230 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of MMAD hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. IC50 value: Target: Tubulin; ADCs toxin For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.2383 mL 6.1917 mL 12.3834 mL
5 mM 0.2477 mL 1.2383 mL 2.4767 mL
10 mM 0.1238 mL 0.6192 mL 1.2383 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

807.53

Formula

C₄₁H₆₇ClN₆O₆S

CAS No.

173441-26-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
MMAD hydrochloride
Cat. No.:
HY-79105
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