1. Metabolic Enzyme/Protease
    Neuronal Signaling
    Membrane Transporter/Ion Channel
    Autophagy
  2. Cytochrome P450
    iGluR
    Autophagy
  3. Memantine hydrochloride

Memantine hydrochloride (Synonyms: D-145 (hydrochloride))

Cat. No.: HY-B0365A Purity: >98.0%
Handling Instructions

Memantine (hydrochloride) (D-145 (hydrochloride)), an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

For research use only. We do not sell to patients.

Memantine hydrochloride Chemical Structure

Memantine hydrochloride Chemical Structure

CAS No. : 41100-52-1

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Memantine hydrochloride

    Memantine hydrochloride purchased from MCE. Usage Cited in: Neurochem Res. 2018 Oct;43(10):2008-2015.

    Memantine inhibits the elevated levels of protein P-MARCKS induced by Aβ1-42 oligomers.
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    Description

    Memantine (hydrochloride) (D-145 (hydrochloride)), an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

    IC50 & Target

    NMDA Receptor[1].

    In Vitro

    Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type[1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity[2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1[3].

    Clinical Trial
    Molecular Weight

    215.76

    Formula

    C₁₂H₂₂ClN

    CAS No.

    41100-52-1

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 33.33 mg/mL (154.48 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.6348 mL 23.1739 mL 46.3478 mL
    5 mM 0.9270 mL 4.6348 mL 9.2696 mL
    10 mM 0.4635 mL 2.3174 mL 4.6348 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    MemantineD-145D145D 145Cytochrome P450iGluRAutophagyCYPsIonotropic glutamate receptorsInhibitorinhibitorinhibit

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    Product name:
    Memantine hydrochloride
    Cat. No.:
    HY-B0365A
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