Monensin (Synonyms: Monensin A)

Cat. No.: HY-N4302: FAQs
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Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na⁺/H⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Monensin sodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Monensin Chemical Structure

CAS No. : 17090-79-8

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Other In-stock Forms of Monensin:

Other Forms of Monensin:

Monensin sodium In-stock

18 Publications Citing Use of MCE Monensin

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Monensin (1-5 μM; 48 h) results in a marked decrease in viability in a dose-dependent manner^[1].
Monensin (1-5 μM; 24 h) shows a statistically significant induction of apoptosis^[1].
Monensin (0.1-1 μM; 24 h) inhibits pEGFR and its downstream targets pAKT and pERK^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SCC9, SCC25, and GM-38 cell lines
Concentration:	1-5 μM
Incubation Time:	48 h
Result:	Resulted in a marked decrease in viability in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:	SCC25 cells
Concentration:	1 μM, or 5 μM
Incubation Time:	24 hours
Result:	Induced a potent apoptotic response.

Western Blot Analysis^[1]

Cell Line:	SCC9 and SCC25 cells
Concentration:	0.1 μM, or 1 μM
Incubation Time:	24 hours
Result:	Induced approximately a 50% inhibition of EGF-treated SCC9 cells with respect to pEGFR and its downstream targets pAKT and pERK.

In Vivo

Monensin (10 mg/kg; po; daily; for 6 weeks) suppresses progression of the intestinal tumors without any sign of toxicity on normal mucosa in multiple intestinal neoplasia (Min) mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Multiple intestinal neoplasia (Min) mice (four-week-old) ^[2]
Dosage:	10 mg/kg
Administration:	Orally application; daily; for 6 weeks
Result:	Suppressed progression of the intestinal tumors without any sign of toxicity on normal mucosa.

Molecular Weight

670.87

Formula

C₃₆H₆₂O₁₁

CAS No.

17090-79-8

SMILES

C[C@]1([C@]2([H])O[C@@](CC2)([C@]3([H])O[C@]([C@@]4([H])O[C@](O)([C@@H](C[C@@H]4C)C)CO)([H])C[C@@H]3C)CC)O[C@@]5(CC1)O[C@]([C@@H]([C@H](C5)O)C)([H])[C@@H](C)[C@@H](OC)[C@H](C)C(O)=O

Structure Classification

Others

Initial Source

Microorganisms

Streptomyces spp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dayekh K, et al. Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors. Mol Cancer Ther. 2014 Nov;13(11):2559-71. [Content Brief]

[2]. Tumova L, et al. Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Mol Cancer Ther. 2014 Apr;13(4):812-22. [Content Brief]

[3]. Youhua Huang, et al. Autophagy Participates in Lysosomal Vacuolation-Mediated Cell Death in RGNNV-Infected Cells. Front Microbiol. 2020 Apr 30:11:790. [Content Brief]

[4]. Ariel Savina, et al. Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic. 2005 Feb;6(2):131-43. [Content Brief]

Monensin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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