1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Nalfurafine hydrochloride

Nalfurafine hydrochloride (Synonyms: TRK-820 hydrochloride)

Cat. No.: HY-12745A Purity: 99.93%
Handling Instructions

Nalfurafine hydrochloride (TRK-820 hydrochloride) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential. Nalfurafine hydrochloride (TRK-820 hydrochloride) enhances the therapeutic potential of MOR-targeting analgesics, has the potential for uremic pruritis treatment.

For research use only. We do not sell to patients.

Nalfurafine hydrochloride Chemical Structure

Nalfurafine hydrochloride Chemical Structure

CAS No. : 152658-17-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 488 In-stock
Estimated Time of Arrival: December 31
5 mg USD 432 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2160 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 2 publication(s) in Google Scholar

Other Forms of Nalfurafine hydrochloride:

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Description

Nalfurafine hydrochloride (TRK-820 hydrochloride) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential[1]. Nalfurafine hydrochloride (TRK-820 hydrochloride) enhances the therapeutic potential of MOR-targeting analgesics, has the potential for uremic pruritis treatment[2].

In Vivo

Nalfurafine (subcutaneous injection; 0.015 mg/kg) combines with EOM-salvinorin-B  produces spinal antinociception equivalent to 5 mg/kg, it also enhances the supraspinal analgesic effect of 5 mg/kg morphine[1].
Nalfurafine (subcutaneous injection; 4 μg/kg) causes a dose-dependent increase of the inhibition of the acetic acid-induced abdominal constriction,and the inhibition of the abdominal constriction reaches its peak 30 min after injection, gradually declined and returned to the pre-injection level 4 hr after[2].

Animal Model: Male and Female C57BL/6J mice[1]
Dosage: 0.015 mg/kg
Administration: Subcutaneous injection
Result: Had the potential for enhancing the therapeutic potential of MOR-targeting analgesics, such as morphine.
Clinical Trial
Molecular Weight

513.03

Formula

C₂₈H₃₃ClN₂O₅

CAS No.

152658-17-8

SMILES

O[[email protected]@]1(CC[[email protected]@H](N(C)C(/C=C/C2=COC=C2)=O)[[email protected]]3([H])OC4=C5O)[[email protected]]63C4=C(C=C5)C[[email protected]@]1([H])N(CC7CC7)CC6.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 21 mg/mL (40.93 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9492 mL 9.7460 mL 19.4920 mL
5 mM 0.3898 mL 1.9492 mL 3.8984 mL
10 mM 0.1949 mL 0.9746 mL 1.9492 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NalfurafineTRK-820TRK820TRK 820Opioid ReceptoragonistanalgesicuremicpruritisInhibitorinhibitorinhibit

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Nalfurafine hydrochloride
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