1. Immunology/Inflammation
    Apoptosis
  2. PD-1/PD-L1
    Apoptosis
  3. BMS-1

BMS-1 (Synonyms: PD-1/PD-L1 inhibitor 1)

製品番号: HY-19991 純度: 99.61%
取扱説明書

BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM).

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BMS-1 構造式

BMS-1 構造式

CAS 番号 : 1675201-83-8

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1  mL in DMSO USD 158 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 144 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 228 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 456 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 660 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 1056 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 3 publication(s) in Google Scholar

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製品説明

BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM)[1][2].

IC50 & Target

PD1-PDL1[1]

体外実験

Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1[1]. BMS-1, a small-molecule immune checkpoint inhibitor of PD-1/PD-L1, can be used as a therapeutic strategy for tumor immunotherapy[2].

Cell Cytotoxicity Assay[1]

Cell Line: NK cells and HepG2 cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Disturbed the interaction between PD-1 and PD-L1.
体内実験

BMS-1 (500 μg/mL; 100 μL; i.p.) significantly slows down tumor growth and prolongs the survival rates in BALB/c mice[3].

Animal Model: BALB/c mice[3]
Dosage: 500 μg/mL; 100 μL
Administration: I.p.
Result: Administration significantly slowed down tumor growth and prolonged the survival rates.
分子量

475.58

分子式

C₂₉H₃₃NO₅

CAS 番号

1675201-83-8

SMILES

O=C([[email protected]]1N(CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC)CCCC1)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 10 mg/mL (21.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1027 mL 10.5135 mL 21.0270 mL
5 mM 0.4205 mL 2.1027 mL 4.2054 mL
10 mM 0.2103 mL 1.0513 mL 2.1027 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BMS-1PD-1/PD-L1 inhibitor 1BMS1BMS 1PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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Inquiry Information

製品名:
BMS-1
製品番号:
HY-19991
数量:
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