JAK-IN-11

Cat. No.: HY-U00318 Purity: 98.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment. JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

JAK-IN-11 Chemical Structure

CAS No. : 916742-11-5

Size	Price	Stock	Quantity
1 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1950	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3550	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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JAK1 JAK2 JAK3 Tyk2 JAK

Biological Activity
Purity & Documentation
References
Customer Review

Description

JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment^[1]. JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

JAK

In Vitro

JAK kinases are a family of cytoplasmic protein tyrosine kinases including JAK1, JAK2, JAK3 and TYK2. STAT proteins function both as signaling molecules and transcription factors and ultimately bind to specific DNA sequences present in the promoters of cytokine-responsive genes. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses such as allergies, asthma, autoimmune diseases such as transplant rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, ocular disorders and diseases, as well as in solid and hematologic malignancies such as leukemia and lymphomas^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.52

Formula

C₂₃H₂₂FN₅O₄S

CAS No.

916742-11-5

Appearance

Solid

Color

Off-white to light yellow

SMILES

C#CCOC1=CC=C(NC2=NC(NC3=CC=C(C)C(S(=O)(NC(CC)=O)=O)=C3)=NC=C2F)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (258.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0682 mL	10.3408 mL	20.6817 mL
5 mM	0.4136 mL	2.0682 mL	4.1363 mL
10 mM	0.2068 mL	1.0341 mL	2.0682 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.62%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (258 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Daniel Magilavy, et al. 2,4 substituted pyrimidinediamines for use in discoid lupus. WO2012122452A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0682 mL	10.3408 mL	20.6817 mL	51.7042 mL
	5 mM	0.4136 mL	2.0682 mL	4.1363 mL	10.3408 mL
	10 mM	0.2068 mL	1.0341 mL	2.0682 mL	5.1704 mL
	15 mM	0.1379 mL	0.6894 mL	1.3788 mL	3.4469 mL
	20 mM	0.1034 mL	0.5170 mL	1.0341 mL	2.5852 mL
	25 mM	0.0827 mL	0.4136 mL	0.8273 mL	2.0682 mL
	30 mM	0.0689 mL	0.3447 mL	0.6894 mL	1.7235 mL
	40 mM	0.0517 mL	0.2585 mL	0.5170 mL	1.2926 mL
	50 mM	0.0414 mL	0.2068 mL	0.4136 mL	1.0341 mL
	60 mM	0.0345 mL	0.1723 mL	0.3447 mL	0.8617 mL
	80 mM	0.0259 mL	0.1293 mL	0.2585 mL	0.6463 mL
	100 mM	0.0207 mL	0.1034 mL	0.2068 mL	0.5170 mL

JAK-IN-11 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK-IN-11916742-11-5JAKJanus kinaseskindisorderscutaneouslupusInhibitorinhibitorinhibit

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