1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. JAK-IN-11

JAK-IN-11 

Cat. No.: HY-U00318
Handling Instructions

JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment.

For research use only. We do not sell to patients.

JAK-IN-11 Chemical Structure

JAK-IN-11 Chemical Structure

CAS No. : 916742-11-5

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Description

JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment[1].

IC50 & Target[1]

JAK

 

In Vitro

JAK kinases are a family of cytoplasmic protein tyrosine kinases including JAK1, JAK2, JAK3 and TYK2. STAT proteins function both as signaling molecules and transcription factors and ultimately bind to specific DNA sequences present in the promoters of cytokine-responsive genes. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses such as allergies, asthma, autoimmune diseases such as transplant rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, ocular disorders and diseases, as well as in solid and hematologic malignancies such as leukemia and lymphomas[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.52

Formula

C₂₃H₂₂FN₅O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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JAK-IN-11
Cat. No.:
HY-U00318
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