1. PI3K/Akt/mTOR
  2. PI3K
    mTOR
  3. PI3Kα/mTOR-IN-1

PI3Kα/mTOR-IN-1 

Cat. No.: HY-U00326
Handling Instructions

PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

For research use only. We do not sell to patients.

PI3Kα/mTOR-IN-1 Chemical Structure

PI3Kα/mTOR-IN-1 Chemical Structure

CAS No. : 1013098-90-2

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Description

PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

IC50 & Target[1]

PI3Kα

7 nM (IC50, Cell Assay)

PI3Kα

12.5 nM (Ki)

mTOR

10.6 nM (Ki)

In Vitro

PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties[1].

In Vivo

PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1].

Molecular Weight

310.35

Formula

C₁₆H₁₈N₆O

CAS No.

1013098-90-2

SMILES

O=C1C(C2=CNN=C2)=CC3=C(C)N=C(N)N=C3N1C4CCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PI3Kα/mTOR-IN-1PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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