1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
    5-HT Receptor
  3. (4E)-SUN9221

(4E)-SUN9221 

Cat. No.: HY-U00367
Handling Instructions

(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

For research use only. We do not sell to patients.

(4E)-SUN9221 Chemical Structure

(4E)-SUN9221 Chemical Structure

CAS No. : 222318-55-0

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Description

(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

IC50 & Target

5-HT2 Receptor

 

α1

 

In Vitro

(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.54

Formula

C₂₅H₃₁FN₄O₃

CAS No.

222318-55-0

SMILES

O=C(C1=C/2C=CN1CCCCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)N(C)CCC2=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(4E)-SUN9221Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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