1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK
  3. (Rac)-Nedisertib

(Rac)-Nedisertib (Synonyms: (Rac)-M3814)

Cat. No.: HY-101570B
Handling Instructions

(Rac)-Nedisertib ((Rac)-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM.

For research use only. We do not sell to patients.

(Rac)-Nedisertib Chemical Structure

(Rac)-Nedisertib Chemical Structure

CAS No. : 1637542-34-7

Size Price Stock
10 mM * 1  mL in DMSO USD 187 Ask For Quote & Lead Time
5 mg USD 170 Ask For Quote & Lead Time
10 mg USD 270 Ask For Quote & Lead Time
25 mg USD 490 Ask For Quote & Lead Time
50 mg USD 790 Ask For Quote & Lead Time
100 mg USD 1300 Ask For Quote & Lead Time

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Description

(Rac)-Nedisertib ((Rac)-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1].

IC50 & Target[1]

DNA-PK

<3 nM (IC50)

In Vitro

(Rac)-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene)[1].

Molecular Weight

481.91

Formula

C₂₄H₂₁ClFN₅O₃

CAS No.

1637542-34-7

SMILES

ClC1=C(C(O)C2=NN=C(OC)C=C2)C=C(C3=C4C=CC(N5CCOCC5)=CC4=NC=N3)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (207.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0751 mL 10.3754 mL 20.7508 mL
5 mM 0.4150 mL 2.0751 mL 4.1502 mL
10 mM 0.2075 mL 1.0375 mL 2.0751 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(Rac)-Nedisertib(Rac)-M3814DNA-PKDNA-dependent protein kinaseInhibitorinhibitorinhibit

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(Rac)-Nedisertib
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