1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK
  3. Rac-Nedisertib

Rac-Nedisertib (Synonyms: Rac-M3814)

Cat. No.: HY-101570B
Handling Instructions

Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM.

For research use only. We do not sell to patients.

Rac-Nedisertib Chemical Structure

Rac-Nedisertib Chemical Structure

CAS No. : 1637542-34-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 187 In-stock
Estimated Time of Arrival: December 31
5 mg USD 170 In-stock
Estimated Time of Arrival: December 31
10 mg USD 270 In-stock
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Estimated Time of Arrival: December 31
50 mg USD 790 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1].

IC50 & Target[1]

DNA-PK

<3 nM (IC50)

In Vitro

Rac-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene) ).[1].

Molecular Weight

481.91

Formula

C₂₄H₂₁ClFN₅O₃

CAS No.

1637542-34-7

SMILES

ClC1=C(C(O)C2=NN=C(OC)C=C2)C=C(C3=C4C=CC(N5CCOCC5)=CC4=NC=N3)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (207.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0751 mL 10.3754 mL 20.7508 mL
5 mM 0.4150 mL 2.0751 mL 4.1502 mL
10 mM 0.2075 mL 1.0375 mL 2.0751 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Rac-Nedisertib
Cat. No.:
HY-101570B
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