Regorafénib N-oxyde (M2)

Cat. No.: HY-I0678 Purity: 98.27%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC₅₀s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

For research use only. We do not sell to patients.

Regorafénib N-oxyde (M2) Chemical Structure

CAS No. : 835621-11-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 121	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 121	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 52	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Regorafénib N-oxyde (M2):

Regorafénib N-oxyde-d₃(M2) Get quote
Regorafénib N-oxyde (M2)-¹³C,d₃ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

498.81

Formula

C₂₁H₁₅ClF₄N₄O₄

CAS No.

835621-11-9

Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (100.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0048 mL	10.0239 mL	20.0477 mL
5 mM	0.4010 mL	2.0048 mL	4.0095 mL
10 mM	0.2005 mL	1.0024 mL	2.0048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.27%

Select Batch:

Data Sheet (267 KB) SDS (0 KB)

COA (246 KB) LCMS (270 KB)

Handling Instructions (2659 KB)

References

[1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0048 mL	10.0239 mL	20.0477 mL	50.1193 mL
	5 mM	0.4010 mL	2.0048 mL	4.0095 mL	10.0239 mL
	10 mM	0.2005 mL	1.0024 mL	2.0048 mL	5.0119 mL
	15 mM	0.1337 mL	0.6683 mL	1.3365 mL	3.3413 mL
	20 mM	0.1002 mL	0.5012 mL	1.0024 mL	2.5060 mL
	25 mM	0.0802 mL	0.4010 mL	0.8019 mL	2.0048 mL
	30 mM	0.0668 mL	0.3341 mL	0.6683 mL	1.6706 mL
	40 mM	0.0501 mL	0.2506 mL	0.5012 mL	1.2530 mL
	50 mM	0.0401 mL	0.2005 mL	0.4010 mL	1.0024 mL
	60 mM	0.0334 mL	0.1671 mL	0.3341 mL	0.8353 mL
	80 mM	0.0251 mL	0.1253 mL	0.2506 mL	0.6265 mL
	100 mM	0.0200 mL	0.1002 mL	0.2005 mL	0.5012 mL