1. Others
  2. Others

TS-011 

Cat. No.: HY-15603
Handling Instructions

TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.

For research use only. We do not sell to patients.

TS-011 Chemical Structure

TS-011 Chemical Structure

CAS No. : 339071-18-0

Size Price Stock
1 mg USD 751 Get quote
5 mg USD 1202 Get quote
10 mg USD 2137 Get quote

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.

In Vivo

TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9108 mL 19.5542 mL 39.1083 mL
5 mM 0.7822 mL 3.9108 mL 7.8217 mL
10 mM 0.3911 mL 1.9554 mL 3.9108 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

The studies are performed using 58 male C57BL/6J mice (8 weeks old) weighing 20 to 26 g. TS-011 (0.3 mg/kg) or a vehicle is infused intravenously for 1 h every 6 h in a mouse model of stroke, induced by transient occlusion of the middle cerebral artery occlusion following photothrombosis. The cerebral blood flow velocity and the vascular perfusion area of the peri-infarct microvessels are measured using in vivo two-photon imaging[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

255.70

Formula

C₁₁H₁₄ClN₃O₂

CAS No.

339071-18-0

SMILES

ClC(C=C(/N=C/NO)C=C1)=C1N2CCOCC2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TS-011
Cat. No.:
HY-15603
Quantity:

TS-011

Cat. No.: HY-15603