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Cat. No.: HY-15603
Handling Instructions

TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.

For research use only. We do not sell to patients.

TS-011 Chemical Structure

TS-011 Chemical Structure

CAS No. : 339071-18-0

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1 mg USD 751 Get quote
5 mg USD 1202 Get quote
10 mg USD 2137 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.

In Vivo

TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9108 mL 19.5542 mL 39.1083 mL
5 mM 0.7822 mL 3.9108 mL 7.8217 mL
10 mM 0.3911 mL 1.9554 mL 3.9108 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

The studies are performed using 58 male C57BL/6J mice (8 weeks old) weighing 20 to 26 g. TS-011 (0.3 mg/kg) or a vehicle is infused intravenously for 1 h every 6 h in a mouse model of stroke, induced by transient occlusion of the middle cerebral artery occlusion following photothrombosis. The cerebral blood flow velocity and the vascular perfusion area of the peri-infarct microvessels are measured using in vivo two-photon imaging[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-15603