1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. ADC Linker Inhibitors

ADC Linker Inhibitors

Cleavable

Noncleavable

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ADC Linker
Product Name Cleavable Noncleavable Purity
SPDP
Cleavable
  98.45%
Val-cit-PAB-OH
Cleavable
  99.64%
MC-Val-Cit-PAB
Cleavable
  99.69%
Fmoc-Val-Cit-PAB-PNP
Cleavable
  96.13%
Sulfo-SMCC sodium  
Noncleavable
>95.0%
Boc-NH-C6-Br
Cleavable
  >95.0%
Vipivotide tetraxetan Linker  
Noncleavable
Mc-Val-Cit-PABC-PNP
Cleavable
  98.68%
SPDB
Cleavable
  99.30%
6-Maleimidohexanoic acid N-hydroxysuccinimide ester  
Noncleavable
99.96%
BMPS  
Noncleavable
98.94%
Mal-amido-PEG8-C2-acid  
Noncleavable
Fmoc-Val-Cit-PAB
Cleavable
  98.13%
Fmoc-Phe-Lys(Boc)-PAB-PNP
Cleavable
  98.67%
Boc-Gly-Gly-Phe-Gly-OH
Cleavable
 
SNPB-sulfo-Me
Cleavable
 
NO2-SPP
Cleavable
 
Cbz-Phe-(Alloc)Lys-PAB-PNP
Cleavable
 
SNPB
Cleavable
 
PDEC-NB
Cleavable
 
Mal-Phe-C4-Val-Cit-PAB-DMEA
Cleavable
 
Mal-amido-PEG10-C2-​NHS ester  
Noncleavable
Mal-amido-PEG5-C2-​NHS ester  
Noncleavable
Mal-Phe-C4-Val-Cit-PAB
Cleavable
 
N3-C5-NHS ester  
Noncleavable
Fmoc-Gly-Gly-Phe-OtBu
Cleavable
  99.80%
Bis-PEG1-NHS ester  
Noncleavable
NH-bis(C1-Boc)  
Noncleavable
Mal-L-PA-NH-Boc  
Noncleavable
Ald-Ph-amido-PEG2-C2-Pfp ester  
Noncleavable
Propargyl-O-C1-amido-PEG2-C2-NHS ester  
Noncleavable
N3-PEG3-C2-PFP ester  
Noncleavable
Ald-Ph-amido-PEG1-C2-NHS ester  
Noncleavable
Sulfo-SNPB
Cleavable
 
PDB-Pfp  
Noncleavable
Fmoc-Ala-Ala-Asn-PABC-PNP
Cleavable
 
N3-C3-NHS ester  
Noncleavable
Ald-Ph-amido-PEG2-C2-NHS ester  
Noncleavable
Mal-​PEG4-​NHS ester  
Noncleavable
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
Cleavable
 
MAC glucuronide linker-2
Cleavable
 
AMAS  
Noncleavable
MC-PEG2-C2-​NHS ester  
Noncleavable
Ald-Ph-amido-PEG2  
Noncleavable
Propargyl-C1-NHS ester  
Noncleavable
MC-Gly-Gly-Phe
Cleavable
 
Mal-PEG6-NHS ester  
Noncleavable
trans-Sulfo-SMCC  
Noncleavable
Ald-Ph-amido-PEG4-C2-acid  
Noncleavable
Mp-polymer ester  
Noncleavable
Ald-Ph-amido-PEG3-C2-Pfp ester  
Noncleavable
N3-PEG4-C2-Pfp ester  
Noncleavable
Mal-amido-PEG2-NHS ester  
Noncleavable
6-O-2-Propyn-1-yl-D-galactose  
Noncleavable
Ald-Ph-amido-PEG3-C1-Boc  
Noncleavable
Fmoc-Phe-Lys(Trt)-PAB-PNP
Cleavable
 
N3-C4-NHS ester  
Noncleavable
Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA
Cleavable
 
Sulfo-LC-SPDP
Cleavable
 
Ald-Ph-NHS ester  
Noncleavable
Boc-Gly-Gly-Phe-Gly-OH TFA
Cleavable
  98.27%
Boc-Phe-(Alloc)Lys-PAB-PNP
Cleavable
 
Mal-amido-(CH2COOH)2
Cleavable
 
Mal-PEG4-VC-PAB-DMEA
Cleavable
 
PEG4-SPDP
Cleavable
 
DBCO-NHS ester 3
Cleavable
 
Mal-PEG2-VCP-NB  
Noncleavable
NO2-SPP-sulfo-Me
Cleavable
 
PDP-C1-Ph-Val-Cit
Cleavable
 
CL2 Linker
Cleavable
 
Propargyl-C2-NHS ester  
Noncleavable
NHPI-PEG2-C2-Pfp ester  
Noncleavable
EC089
Cleavable
 
Propargyl-PEG1-NHS ester  
Noncleavable
Fmoc-PEA
Cleavable
 
MAC glucuronide linker-1  
Noncleavable
Sulfo-SPP
Cleavable
 
Mal-C2-Gly3-EDA
Cleavable
 
N3-PEG2-C2-PFP ester  
Noncleavable
Ald-Ph-amido-PEG3-C-COOH  
Noncleavable
PDdB-Pfp  
Noncleavable
Mal-PEG3-NHS ester  
Noncleavable
N3-Ph-NHS ester  
Noncleavable
Ald-Ph-amido-PEG1-C2-Pfp ester  
Noncleavable
4-N3Pfp-NHS ester  
Noncleavable
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate
Cleavable
 
Bis-​PEG2-​NHS ester  
Noncleavable
N3-C2-NHS ester  
Noncleavable
Ala-Ala-Asn-PAB
Cleavable
 
DBCO-(PEG2-Val-Cit-PAB)2
Cleavable
 
DMAC-PDB
Cleavable
 
NHPI-PEG2-C2-NHS ester  
Noncleavable
Phe-Lys(Fmoc)-PAB
Cleavable
 
SPDV
Cleavable
 
Succinic anhydride  
Noncleavable
>95.0%
Mal-PEG4-Val-Cit-PAB
Cleavable
 
Mc-Leu-Gly-Arg
Cleavable
 
Sulfo-SIAB  
Noncleavable
Propargyl-O-C1-amido-PEG4-C2-NHS ester  
Noncleavable
Ald-Ph-amido-C2-nitrate  
Noncleavable
N3-PEG3-C2-NHS ester  
Noncleavable
Propargyl-PEG4-NHS ester  
Noncleavable
Ald-Ph-amido-PEG4-C2-NHS ester  
Noncleavable
Fmoc-Gly-Gly-D-Phe-OtBu
Cleavable
  98.28%
Mc-Val-Cit-PAB-Cl
Cleavable
 
Sulfo-SIAB sodium  
Noncleavable
N3-PEG2-C2-NHS ester  
Noncleavable
Mal-PEG4-VA  
Noncleavable
Phe-Lys(Trt)-PAB
Cleavable
 
NHPI-PEG3-C2-Pfp ester  
Noncleavable
SPP
Cleavable
 
SC-Val-Cit-PAB
Cleavable
 
Mal-PEG4-PFP ester  
Noncleavable
Mal-C2-NHS ester  
Noncleavable
NHPI-PEG3-C2-NHS ester  
Noncleavable
SPDH
Cleavable
 
Mal-PEG2-NHS ester  
Noncleavable
Bis-PEG3-NHS ester  
Noncleavable
CL2A
Cleavable
 
N3-PEG4-C2-NHS ester  
Noncleavable
Bis-​PEG4-​NHS ester  
Noncleavable
PDdEC-NB
Cleavable
 
(Ac)Phe-Lys(Alloc)-PABC-PNP
Cleavable