Signaling Pathway

ADCs Cytotoxin

ADCs Cytotoxin

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A cytotoxin is any substance which has a toxic effect on cells. Some common examples of cytotoxins include chemical agents and certain snake venoms. Cytotoxins typically attack only a specific type of cell or organ, rather than an entire body. Cells that have been affected by a cytotoxin can perish in several different ways. One is necrosis. In this form of cell death, the cells lose integrity in their membrane wall and collapse. Another type of possible cell death is apoptosis. This type of death is pre-programmed into the cell itself before the cytotoxin arrives. It is typically a beneficial property, as seen when cells in the fingers and toes of developing human babies undergo apoptosis, leading to the separation of digits. Chemotherapy as a treatment of cancer often relies on the ability of these agents to preferentially kill or damage cancer cells as opposed to healthy cells.

ADCs Cytotoxin Inhibitors & Modulators (32)

Product Name Catalog No. Brief Description
10-Deacetyl-7-xylosyl paclitaxel

HY-20584

10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.

alpha-Amanitin

HY-19610

alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.

Ansamitocin P 3'

HY-19839

Ansamitocin P 3' exhibits antitumour activity, is an antibody drug conjugate cytotoxin.

Ansamitocin P-3

HY-15739

Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.

Auristatin E

HY-15582

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

Auristatin F

HY-15583

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

Calicheamicin

HY-19609

Calicheamicin is a potent DNA-binding cytotoxic antibiotic.

Campathecin

HY-16560

Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.

D8-MMAE

HY-15162A

D8-MMAE(D8-Monomethyl auristatin E; D8-Vedotin) is a deuterated form of MMAE.

Daun02

HY-13061

Daun02 is a daunorubicin b-galactoside prodrug for use in conjunction.

Daunorubicin

HY-13062A

Daunorubicin(RP13057) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

Daunorubicin Hydrochloride

HY-13062

Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

Dolastatin 10

HY-15580

Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly.

Doxorubicin

HY-15142A

Doxorubicin(Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Doxorubicin hydrochloride

HY-15142

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Maytansinol

HY-19474

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.

Methotrexate

HY-14519

Methotrexate(WR19039; CL14377) can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Mitomycin C

HY-13316

Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.

MMAD

HY-15581

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.

MMAD hydrochloride

HY-79105

Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.