Signaling Pathway

ADCs Linker

ADCs Linker

Related Products

PDF File 0.23MB

Antibody-drug conjugates (ADCs) are a new class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer. ADCs are complex molecules composed of an antibody, a linker and a biological active cytotoxic. ADCs linkers are based on chemical motifs including disulfides, hydrazones or peptides (cleavable), or thioethers (noncleavable) and control the distribution and delivery of the cytotoxic agent to the target cell. Cleavable and noncleavable types of linkers have been proven to be safe in preclinical and clinical trials. A stable link between the antibody and cytotoxic (anti-cancer) agent is a crucial aspect of an ADC.

ADCs Linker Inhibitors & Modulators (7)

Product Name Catalog No. Brief Description
(Ac)Phe-Lys(Alloc)-PABC-PNP

HY-20560

(Ac)Phe-Lys(Alloc)-PABC-PNP is a useful chemical linker in antibody drug conjugates.

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

HY-78961

6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates.

6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-

HY-21210

6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- is an useful linker for antibody-drug-conjugations (ADCs), extracted from [Bioorg Chem.

Fmoc-Val-Cit-PAB

HY-19318

Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

Fmoc-Val-Cit-PAB-PNP

HY-41189

Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).

Mc-Val-Cit-PABC-PNP

HY-20336

Mc-Val-Cit-PABC-PNP is a cathepsin  cleavable ADC peptide linker.

Val-cit-PAB-OH

HY-12362

Val-cit-PAB-OH is a peptide prodrug linker.