Signaling Pathway

AMPAR

AMPAR

Related Products

PDF File 0.28MB

AMPAR(AMPA receptor) is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS). AMPARs are found in many parts of the brain and are the most commonly found receptor in the nervous system. The AMPA receptor GluA2 (GluR2) tetramer was the first and currently only glutamate receptor ion channel to be crystallized. AMPARs are composed of four types of subunits, designated as GluR1 (GRIA1), GluR2 (GRIA2), GluR3 (GRIA3), and GluR4, alternatively called GluRA-D2 (GRIA4), which combine to form tetramers.

AMPAR Inhibitors & Modulators (21)

Product Name Catalog No. Brief Description
(S)-(-)-5-Fluorowillardiine

HY-16713

(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.

(S)-(-)-5-Fluorowillardiine hydrochloride

HY-16713A

(S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist.

(S)-Willardiine

HY-12499

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.

Ampalex

HY-10933

Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

Aniracetam

HY-10932

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.

CFM-2

HY-12503

CFM-2 is a selective non-competitive AMPAR antagonist.

CMPDA

HY-12508

CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.

CX546

HY-12505

CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.

Farampator

HY-10937

Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.

LY450108

HY-10935

LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator.

LY451395

HY-10934

LY451395(Mibampator) is a potent and highly selective potentiator of the AMPA receptors.

Naspm

HY-12506

Naspm(1-Naphthylacetyl spermine) is a potent and selective Ca2+ permeable AMPA receptor(Ca-perm AMPAR) blocker.

Naspm trihydrochloride

HY-12506A

Naspm 3Hcl(1-Naphthylacetyl spermine) is a potent and selective Ca2+ permeable AMPA receptor(Ca-perm AMPAR) blocker.

Noopept

HY-17456

Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.

Org-26576

HY-101216

Org 26576 is a AMPA receptor positive allosteric modulator.

PEPA

HY-12509

PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

Piracetam

HY-B0585

Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.

SYM2206

HY-18689

SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM).

Talampanel

HY-15079

Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).

ZK200775

HY-15069

ZK200775(Fanapanel; MPQX) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.