Signaling Pathway

Antifungal

Antifungal

Related Products

PDF File 0.51MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Antifungal Inhibitors & Modulators (70)

Product Name Catalog No. Brief Description
(+)-Ketoconazole

HY-B0105A

(+)-Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 inhibitor.

10-Undecenoic acid zinc salt

HY-B0914A

10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

3-(Methylthio)propionic acid

HY-101401

3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.

4',7-Dimethoxyisoflavone

HY-N2145

4',7-Dimethoxyisoflavone is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity.

Amorolfine hydrochloride

HY-B0238

Amorolfine hydrochloride is a antifungal reagent.

Amphotericin B

HY-B0221

Amphotericin B is a polyene, antifungal antibiotic produced from a strain of Streptomyces nodosus.

AN-2690

HY-10980

AN-2690(Tavaborole), an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis.

Anidulafungin

HY-13553

Anidulafungin (LY303366) is a semisynthetic echinocandin used as an antifungal drug.

Ascomycin

HY-13557

Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.

Bifonazole

HY-B0301

Bifonazole is an imidazole antifungal drug.

Butenafine Hydrochloride

HY-17396

Butenafine hydrochloride is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

Butoconazole nitrate

HY-B0293

Butoconazole nitrate is an anti-fungal agent.

Caspofungin Acetate

HY-17006

Caspofungin (Cancidas; L 743872; L 743873; MK 0991) is an antifungal drug.

Cercosporamide

HY-16982

Cercosporamide is a potent and selective Mnk inhibitor, and a orally bioavailable antifungal agent, suppresses phosphorylation of eIF4E and exhibits antileukemic effects.

Chlorquinaldol

HY-B1360

Chlorquinaldol  is a mono-hydroxyquinoline, is an antifungal and antibacterial, used for topical treatment of skin conditions and vaginal infections.

Ciclopirox

HY-B0450

Ciclopirox (Penlac) is a synthetic antifungal agent.

Ciclopirox olamine

HY-B0450A

Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.

Climbazole

HY-B1151

Climbazole is a topical antifungal agent, commonly used in the treatment of human fungal skin infections, such as dandruff and eczema.

Clioquinol

HY-14603

Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death.

Clotrimazole

HY-10882

Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.