Signaling Pathway

Apoptosis Inducer

Apoptosis Inducer

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Apoptosis inducer is a class of compounds that induce apoptosis, the exact mechanism is unknown or involved a series of pathways.

Apoptosis Inducer Inhibitors & Modulators (25)

Product Name Catalog No. Brief Description
(-)-Epigallocatechin Gallate

HY-13653

Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase.

(20S)-Protopanaxadiol

HY-N0797

(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.

(E)-[6]-Dehydroparadol

HY-77293

(E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.

Adarotene

HY-14808

Adarotene (ST1926) is an effective apoptosis inducer and surprisingly produced DNA damage.

Apoptosis Activator 2

HY-18633

Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.

Baohuoside I

HY-N0011

Baohuoside I (Icariside-II) is a component of Epimedium koreanum; a regulator of CXCR4 expression as well as function in cervical cancer and breast cancer cells; Apoptosis inducer.

Betulin

HY-N0083

Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with IC50 value of 14.5 μM in K562 cell line.

Betulinic acid

HY-10529

Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M.

Bisdemethoxycurcumin

HY-N0007

Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

Cisplatin

HY-17394

Cisplatin(CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts.

Costunolide

HY-N0036

Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.

Demethoxycurcumin

HY-N0006

Demethoxycurcumin(Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

Desacetylcinobufotalin

HY-N0882

Desacetylcinobufotalin is a natural compound; apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml.

Ecteinascidin 770

HY-101191

Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM.

Elesclomol

HY-12040

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.

Epibrassinolide

HY-N0848

Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.

Episilvestrol

HY-15359

Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).

Ginsenoside Rg6

HY-N0907

Ginsenoside Rg6 is a compound extracted from steamed notoginseng; apoptosis indecer.

Honokiol

HY-N0003

Honokiol(NSC-293100), a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis, has been reported to have anticancer activities in a variety of cancer cell lines.

Meisoindigo

HY-13680

Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).