Signaling Pathway

Axl

Axl

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AXL is a transmembrane receptor tyrosine kinase. Axl is an oncogenic receptor tyrosine kinase that plays multiple roles in tumorigenesis and metastasis of many cancers. Activation of the AXL receptor initiates various signaling pathways involved in cell survival, proliferation, apoptosis inhibition, migration, cell adhesion, and cytokine production. This is mediated via interactions with a spectrum of signaling molecules, including PI3K/Akt, ERK1/ERK2, GRB2, RAS, RAF1, MEK-1, and SOCS-1. Beyond its overexpression and oncogenic potential in numerous cancers, AXL has also been implicated in angiogenesis and metastasis.

Axl Inhibitors & Modulators (10)

Product Name Catalog No. Brief Description
BMS 777607

HY-12076

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

Cabozantinib

HY-13016

Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

Gilteritinib

HY-12432

Gilteritinib(ASP-2215) is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/<1 nM respectively; shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.

Glesatinib hydrochloride

HY-19642A

Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered.

LDC1267

HY-12494

LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively.

R428

HY-15150

R428 is a potent and selective small-molecule inhibitor(IC50=14 nM), blocks the activities of Axl.

S49076

HY-12965

S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.

SGI-7079

HY-12964

SGI-7079 is an Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 μM, respectively.

TP-0903

HY-12963

TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM.

UNC2881

HY-15798

UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.