1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2 Family Inhibitors

Bcl-2 Family Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Bcl-2 Family Inhibitors, Antagonists, Activators & Modulators
Product Name Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim Purity
Venetoclax
Bcl-2, Ki: 0.01 nM
Bcl-xL, Ki: 48 nM
Bcl-W, Ki: 245 nM
            99.95%
Navitoclax
Bcl-2, Ki: 1 nM
Bcl-xL, Ki: 1 nM
Bcl-W, Ki: 1 nM
            99.97%
S63845      
MCL1, Kd: 0.19 nM
          99.94%
ABT-737
Bcl-2, EC50: 30.3 nM
Bcl-xL, EC50: 78.7 nM
Bcl-W, EC50: 197.8 nM
   
Bcl-B, EC50: 1820 nM
      99.59%
A-1331852
Bcl-2, Ki: 6 nM
Bcl-xL, Ki: 0.01 nM
Bcl-W, Ki: 4 nM
Mcl-1, Ki: 142 nM
          99.81%
XZ739  
Bcl-xL, DC50: 2.5 nM
             
WEHI-539  
Bcl-xL, IC50: 1.1 nM
             
AZD-5991      
Mcl-1, IC50: 0.7 nM
Mcl-1, Kd: 0.17 nM
          99.50%
Obatoclax Mesylate
Bcl-2, Ki: 220 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
      99.74%
AMG-176      
Mcl-1, Ki: 0.13 nM
          99.53%
A-1155463
Bcl-2, Ki: 80 nM
Bcl-xL, Ki: 0.01 nM
              99.62%
WEHI-539 hydrochloride  
Bcl-xL, IC50: 1.1 nM
              98.16%
Bax inhibitor peptide V5            
Bax
    99.62%
A-1210477
Bcl-2, Ki: 132 nM
 
Bcl-W, Ki: 2280 nM
Mcl-1, Ki: 0.45 nM
Bfl-1, Ki: 660 nM
        98.89%
MIK665      
Mcl-1, IC50: 1.81 nM
          98.81%
S55746
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
              98.97%
BAI1            
Bax
    99.72%
BT2      
Mcl-1, Ki: 59 μM
          98.10%
Gossypol (acetic acid)
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
              99.41%
Gambogic Acid
Bcl-2, IC50: 1.21 μM
Bcl-xL, IC50: 1.47 μM
Bcl-W, IC50: 2.02 μM
Mcl-1, IC50: 0.79 μM
Bfl-1, IC50: 1.06 μM
Bcl-B, IC50: 0.66 μM
      95.06%
Glycocholic acid
Bcl-2
         
Bax
    >98.0%
BAM7            
Bax, IC50: 3.3 μM
    99.57%
TW-37
Bcl-2, Ki: 290 nM
Bcl-xL, Ki: 1110 nM
 
Mcl-1, Ki: 260 nM
          98.50%
Maritoclax      
Mcl-1, IC50: 10.1 μM
          99.97%
PROTAC Bcl2 degrader-1
Bcl-2, DC50: 3 μM
Bcl-2, IC50: 4.94 μM
   
Mcl-1, IC50: 11.81 μM
          98.28%
(R)-(-)-Gossypol acetic acid
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
          97.40%
MIM1      
Mcl-1
          >98.0%
Gossypol
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
              99.03%
PROTAC Mcl1 degrader-1      
Mcl-1, IC50: 0.78 μM
          98.13%
A-385358
Bcl-2, Ki: 67 nM
Bcl-xL, Ki: 0.8 nM
              99.05%
Jaceosidin            
Bax
    99.99%
Dehydrocorydaline
Bcl-2
         
Bax
    99.01%
VU0661013      
Mcl-1
          98.42%
Mcl1-IN-8      
Mcl-1, Ki: 0.3 μM
          >98.0%
BTSA1            
Bax, IC50: 250 nM
Bax, EC50: 144 nM
    99.74%
HA14-1
Bcl-2, IC50: 9 μM
                >98.0%
BH3I-1
Bcl-2
Bcl-xL
         
Bak
Bim
>98.0%
(E)-Ferulic acid            
Bax
    99.20%
Thevetiaflavone
Bcl-2
         
Bax
   
Mcl1-IN-1      
Mcl-1, IC50: 2.4 μM
          98.40%
Mcl1-IN-2      
Mcl-1
          >95.0%
AZD4320
BCL2, IC50: 17 nM (KPUM-UH1 cells)
BCLxL, IC50: 17 nM (KPUM-UH1 cells)
              99.10%
Paris saponin VII
Bcl-2
                >99.0%
ML311      
Mcl-1
       
Bim
98.04%
(R)-(-)-Gossypol
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
         
(S)-Gossypol acetic acid
Bcl-2
Bcl-xL
              >98.0%
Pyridoclax      
Mcl-1
          99.74%
Sabutoclax
BCL2, IC50: 0.32 μM
Bcl-xL, IC50: 0.31 μM
 
Mcl-1, IC50: 0.2 μM
Bfl-1, IC50: 0.62 μM
       
Obatoclax
BCL2, Ki: 200 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
     
Navitoclax-piperazine  
Bcl-xL
              98.83%
MCL-1/BCL-2-IN-1
Bcl-2, IC50: 3.18 μM
   
Mcl-1, IC50: 4.45 μM
          98.04%
TCPOBOP
Bcl-2
               
PROTAC Bcl-xL degrader-1  
Bcl-xL
             
BM 957
Bcl-2, IC50: 5.4 nM
Bcl-2, Ki: 1.2 nM
Bcl-xL, IC50: 6.0 nM
Bcl-xL, Ki: <1 nM
             
Destruxin B
Bcl-2
               
MSN-125            
Bax
Bak
 
Bcl-2-IN-2
Bcl-2, IC50: 0.034 nM
Bcl-xL, IC50: 43 nM
             
PUMA BH3              
Bak, Kd: 26 nM
 
Bz 423            
Bax
Bak
  99.79%
PUMA BH3 TFA              
Bak, Kd: 26 nM
 
(+)-Apogossypol
Bcl-2, EC50: 2.8 μM
Bcl-xL, EC50: 3.69 μM
 
Mcl-1, EC50: 2.6 μM
         
Bak BH3  
Bcl-xL