1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CCR
  4. CCR Inhibitors

CCR Inhibitors

CCR1

CCR2

CCR3

CCR4

CCR5

CCR6

CCR7

CCR8

CCR9

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CCR Inhibitors, Agonists & Antagonists
Product Name CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 Purity
Maraviroc        
MIP-1α-CCR5, IC50: 3.3 nM (in HEK-293 cell membrane)
MIP-1β-CCR5, IC50: 7.2 nM (in HEK-293 cell membrane)
RANTES-CCR5, IC50: 5.2 nM (in HEK-293 cell membrane)
        99.95%
Cenicriviroc  
CCR2, IC50: 5.9 nM
   
CCR5, IC50: 0.29 nM
        98.07%
RS 504393  
CCR2, IC50: 89 nM
              99.18%
INCB3344  
hCCR2, IC50: 5.1 nM
mCCR2, IC50: 9.5 nM
              99.73%
CCR7 Ligand 1            
Human CCR7, Kd: 3 nM
    99.64%
J-113863
CCR1, IC50: 0.9 nM (Human CCR1)
CCR1, IC50: 5.8 nM (Mouse CCR1)
 
CCR3, IC50: 0.58 nM (Human CCR3)
CCR3, IC50: 460 nM (Mouse CCR3)
            >99.0%
CCR1 antagonist 9
CCR1, IC50: 6.8 nM (in calcium flux assay)
               
Cenicriviroc Mesylate  
CCR2, IC50: 5.9 nM
   
CCR5, IC50: 0.29 nM
        98.84%
BX471
MIP-1α-CCR1, Ki: 1 nM
RANTES-CCR1, Ki: 2.8 nM
MCP-3-CCR1, Ki: 5.5 nM
                99.78%
PF-4136309  
Human CCR2, IC50: 5.2 nM
Mouse CCR2, IC50: 13 nM
Rat CCR2, IC50: 17 nM
              99.59%
RS102895 hydrochloride
CCR1, IC50: 17800 nM
CCR2, IC50: 360 nM
              99.69%
TAK-779  
MCP-1-CCR2b, IC50: 27 nM (in CHO/CCR5 cells)
   
MIP-1β-CCR5, IC50: 1 nM (in CHO/CCR5 cells)
RANTES-CCR5, IC50: 1.4 nM (in CHO/CCR5 cells)
MIP-1α-CCR5, IC50: 1 nM (in CHO/CCR5 cells)
        99.73%
MK-0812 Succinate  
CCR2
              99.69%
BMS-813160  
CCR2
   
CCR5
        99.89%
AZD2098      
CCR4
          99.85%
BX471 hydrochloride
MIP-1α-CCR1, Ki: 1 nM
RANTES-CCR1, Ki: 2.8 nM
MCP-3-CCR1, Ki: 5.5 nM
                98.00%
Vercirnon                
CCR9, IC50: 10 nM
98.58%
INCB 3284  
MCP-1-hCCR2, IC50: 3.7 nM
              99.30%
GW 766994    
CCR3, pKi: 7.86
            99.53%
CCR2-RA-[R]  
CCR2, IC50: 103 nM (in U2OS-CCR2 cells)
              99.36%
TAK-220        
RANTES-CCR5, IC50: 3.5 nM (in CHO cells)
MIP-1α-CCR5, IC50: 1.4 nM (in CHO cells)
        99.95%
DAPTA        
gp120BaL/sCD4-CCR5, IC50: 55 pM (in Cf2Th/synR5 cells)
gp120CMCM235/sCD4-CCR5, IC50: 0.32 nM (in Cf2Th/synR5 cells)
        98.73%
ZK756326 dihydrochloride              
CCR8, IC50: 1.8 μM (in U87 cells)
  98.28%
AZ084              
CCR8, Ki: 0.9 nM
  99.36%
Vicriviroc maleate        
CCR5, Ki: 2.5 nM
        99.41%
CCR6 inhibitor 1          
Moneky CCR6, IC50: 0.45 nM
Human CCR6, IC50: 6 nM
Human CCR7, IC50: 9400 nM
    99.82%
BMS CCR2 22  
CCR2, IC50: 5.1 nM
              >99.0%
GSK2239633A      
[125I]-TARC-CCR4, pIC50: 7.96
          99.77%
MK-0812  
CCR2
              99.75%
PF-04634817  
Rat CCR2, IC50: 20.8 nM
   
CCR5, IC50: 470 nM
        98.87%
CCR2 antagonist 4  
CCR2b, IC50: 180 nM
              99.89%
CCR2 antagonist 1  
CCR2, Ki: 2.4 nM
             
Aplaviroc        
CCR5
       
INCB 3284 dimesylate  
MCP-1-hCCR2, IC50: 3.7 nM
              >98.0%
CCR1 antagonist 8
CCR1, IC50: 1.8 nM (in Ca2+ flux assay)
               
PF-04634817 succinate  
Rat CCR2, IC50: 20.8 nM
   
CCR5, IC50: 470 nM
        >99.0%
YM022
CCR1, Ki: 68 pM
CCR2, Ki: 63 nM
              99.00%
CCR2 antagonist 4 hydrochloride  
CCR2b, IC50: 180 nM
             
CCR5 antagonist 1        
CCR5
       
CCR2 antagonist 3  
CCR2
             
C-021 dihydrochloride      
CCR4
          >99.0%
R243              
CCR8
 
AZD2423  
CCR2
             
LMD-009              
CCR8, EC50: 11-87 nM
 
RS102895
CCR1, IC50: 17800 nM
CCR2, IC50: 360 nM
             
CCX354
CCR1
               
CCR3 antagonist 1    
CCR3