1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX Inhibitors

COX Inhibitors

COX

COX-1

COX-2

COX-3

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COX Inhibitors, Antagonists & Activators
Product Name COX COX-1 COX-2 COX-3 Purity
Celecoxib  
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
  99.50%
Acetaminophen  
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
  99.96%
Indomethacin  
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
  99.71%
Aspirin  
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
  99.90%
Ibuprofen  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.99%
Carprofen  
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
  99.76%
Licofelone
COX, IC50: 0.21 μM
      >99.0%
20(S)-Ginsenoside Rg3    
COX-2
  >98.0%
NS-398    
COX-2, IC50: 3.8 μM
  99.86%
Rofecoxib    
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
  99.95%
Catechin  
COX-1, IC50: 1.4 μM
    99.23%
Salicylic acid    
COX-2
  >98.0%
Sulindac    
COX-2
  99.78%
Meloxicam  
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
  98.07%
Paradol    
COX-2
  99.88%
(-)-Epicatechin gallate  
COX-1, IC50: 7.5 μM
    98.57%
Sodium Salicylate    
COX-2
  99.93%
Rutaecarpine  
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
  98.11%
Ginsenoside C-K    
COX-2
  >98.0%
Gallic acid    
COX-2
  99.97%
Diclofenac  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.98%
SC-560  
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
  99.58%
Naproxen  
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
  99.96%
Diflunisal
COX
      99.37%
Nabumetone    
COX-2
  99.86%
Ketoprofen  
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
  99.93%
Diclofenac Sodium  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.93%
Nimesulide    
COX-2, IC50: 0.07-70 μM
  99.91%
(-)-Epicatechin  
COX-1, IC50: 3.2 μM
    99.00%
Isoorientin    
COX-2, IC50: 39 μM
  99.24%
Neochlorogenic acid    
COX-2
  99.46%
Ginsenoside Rg5    
COX-2
  99.86%
Ketorolac tromethamine salt  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
  99.94%
Prim-O-glucosylcimifugin    
COX-2
  99.76%
Piroxicam  
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
  99.73%
Phenacetin      
COX-3, IC50: 102 μM
99.09%
Rebamipide    
COX-2
  99.78%
Fenofibric acid    
COX-2, IC50: 48 μM
  99.67%
Ginsenoside Rd    
COX-2
  >98.0%
Valdecoxib  
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
  99.96%
S-(+)-Ketoprofen  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.95%
Parecoxib Sodium    
COX-2
  99.99%
Mefenamic acid  
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
  99.99%
Oxaprozin  
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
  99.63%
Etoricoxib  
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
  99.92%
(S)-(+)-Ibuprofen  
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
  99.99%
Naproxen sodium  
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
  99.98%
Iguratimod    
COX-2, IC50: 20 μM
  99.97%
Syringaldehyde    
COX-2, IC50: 19.2 μM
  99.96%
Triflusal    
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
  99.66%
Tolmetin sodium dihydrate
COX
      99.77%
Aceclofenac  
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
  99.80%
Flunixin meglumine  
COX-1, IC50: 17 nM
COX-2, IC50: 0.4 nM
  99.65%
Imrecoxib  
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
  99.38%
Guaiacol    
COX-2
  99.29%
Jaceosidin    
COX-2
  99.99%
Ampyrone
COX
      98.86%
Acemetacin  
COX-1, IC50: 85 μM (in human intact cell)
    99.97%
Hexahydrocurcumin    
COX-2
  98.58%
Firocoxib  
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
  98.42%
Tolfenamic Acid    
COX-2, IC50: 13.49 μM (in cell)
  99.93%
(-)-Catechin gallate  
COX-1
COX-2
  99.98%
Fenoprofen Calcium hydrate
COX
      99.35%
Ampiroxicam
COX
      97.12%
Etodolac  
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
  99.10%
Lornoxicam  
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
  98.31%
Deracoxib    
COX-2
  99.82%
Tenoxicam  
COX-1
COX-2
  99.83%
Salicin
COX
      99.60%
Asaraldehyde    
COX-2
  99.68%
SC57666    
COX-2, IC50: 26 nM
  98.94%
Diclofenac diethylamine  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.93%
ATB-346
COX
      98.35%
Phenylbutazone  
COX-1, IC50: 3.7 μM
COX-2, IC50: 1.1 μM
  98.86%
Loxoprofen  
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
  99.76%
Nitroflurbiprofen
COX
      99.64%
Adelmidrol    
COX-2
  >98.0%
Mavacoxib    
COX-2
  99.83%
TFAP  
COX-1, IC50: 0.8 μM
    99.97%
Eicosatetraynoic acid
COX, ID50: 8 μM
     
(+)-Catechin hydrate  
COX-1, IC50: 1.4 μM
    99.22%
[8]-Shogaol    
COX-2, IC50: 17.5 μM
  99.18%
S-(+)-Marmesin    
COX-2
  99.04%
Nepafenac  
COX-1, IC50: 64.3 μM
    95.14%
FR-188582    
COX-2, IC50: 17 nM
  99.21%
Zaltoprofen  
COX-1, IC50: 149 μM
COX-2, IC50: 111 μM
  99.09%
Parecoxib    
COX-2
  99.32%
Pamicogrel
Cyclooxygenase
      >99.0%
Ginsenoside Rb3    
COX-2
  99.12%
Inulicin    
COX-2
  99.38%
Psoralidin    
COX-2
  99.90%
FK 3311    
COX-2
  98.06%
Gnetol  
COX-1, IC50: 0.78 μM
   
Isofraxidin    
COX-2
 
β-Elemonic acid    
COX-2
 
DuP-697  
hCOX-1, IC50: 800 nM
hCOX-2, IC50: 10 nM
 
Ketorolac D5  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 
Roburic acid  
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
 
Amfenac Sodium Hydrate    
COX-2
  98.65%
(E)-Ethyl p-methoxycinnamate  
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
 
Harpagoside  
COX-1
COX-2
 
Nitroaspirin  
COX-1
   
Tenidap  
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
 
(S)-(+)-Ibuprofen D3  
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 
Taraxerol acetate  
COX-1, IC50: 116.3 μM
COX-2, IC50: 94.7 μM
 
Desmethyl Celecoxib    
COX-2, IC50: 32 nM
 
α-​Chaconine    
COX-2
 
[10]-Shogaol    
COX-2, IC50: 7.5 μM
 
α-Humulene    
COX-2
 
GW-406381    
COX-2
  99.59%
Anemarsaponin B    
COX-2
 
Pectolinarigenin    
COX-2
 
Pelubiprofen    
COX-2
 
Cafestol    
COX-2
 
Hamaudol  
COX-1, IC50: 0.3 mM
COX-2, IC50: 0.57 mM
 
N-trans-Feruloyltyramine  
COX-1
COX-2
 
α-Spinasterol  
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
 
Madecassic acid    
COX-2
 
Byakangelicol    
COX-2
 
Timegadine
COX, IC50: 5 nM (in rabbit platelets)
COX, IC50: 20 μM (in rat brain)
     
Ethyl Caffeate    
COX-2
  98.91%
Indobufen
COX
     
Nimesulide D5    
COX-2, IC50: 0.07-70 μM
 
Ketorolac  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 
Fenoprofen Calcium
COX
     
Propyphenazone
COX
      99.94%
LY 178002
Cyclooxygenase
     
RWJ 63556    
COX-2
 
Flosulide    
COX-2
 
Thioflosulide    
COX-2, IC50: 2.3 nM
 
S-2474  
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
 
Tilmacoxib    
Human COX-2, IC50: 85 nM
 
COX/5-LO-IN-1
COX
     
SC58451    
COX-2
 
COX-2-IN-1    
COX-2, IC50: 3.9 μM
 
COX-2-IN-2    
COX-2, IC50: 240 nM