1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX Inhibitors

COX Inhibitors

COX

COX-1

COX-2

COX-3

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COX Inhibitors, Activators & Modulators
Product Name COX COX-1 COX-2 COX-3 Purity
Acetaminophen  
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
  99.96%
Indomethacin  
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
  99.97%
Celecoxib  
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
  99.59%
Aspirin  
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
  ≥99.0%
Ibuprofen  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.97%
Gallic acid hydrate    
COX-2
  ≥98.0%
Lumiracoxib  
COX-1, Ki: 3 μM
COX-2, Ki: 0.06 μM
 
Teriflunomide impurity 3  
COX-1, IC50: 30 μM
    99.87%
Catechin  
COX-1, IC50: 1.4 μM
    ≥99.0%
NS-398    
COX-2, IC50: 3.8 μM
  98.70%
Diclofenac  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.97%
20(S)-Ginsenoside Rg3    
COX-2
  ≥98.0%
Diclofenac Sodium  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.93%
Naproxen  
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
  99.96%
(-)-Epicatechin  
COX-1, IC50: 3.2 μM
    99.0%
Gallic acid    
COX-2
  99.85%
Xanthohumol  
COX-1
COX-2
  99.84%
Sulindac    
COX-2
  99.81%
SC-560  
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
  99.77%
Carprofen  
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
  99.96%
Salicylic acid    
COX-2
  ≥98.0%
Meloxicam  
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
  99.88%
Rutaecarpine  
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
  98.11%
Rebamipide    
COX-2
  99.88%
Iguratimod    
COX-2, IC50: 20 μM
  99.97%
Sodium Salicylate    
COX-2
  ≥99.0%
Isoorientin    
COX-2, IC50: 39 μM
  99.26%
Rofecoxib    
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
  99.91%
Fenofibric acid    
COX-2, IC50: 48 μM
  ≥98.0%
Nabumetone    
COX-2
  99.98%
Neochlorogenic acid    
COX-2
  99.07%
Piroxicam  
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
  99.61%
Ginsenoside C-K    
COX-2
  ≥98.0%
(-)-Epicatechin gallate  
COX-1, IC50: 7.5 μM
    98.57%
Flurbiprofen
COX
COX-1
COX-2
  99.92%
Isofraxidin    
COX-2
  98.14%
Ketoprofen  
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
  99.93%
Etoricoxib  
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
  99.10%
Nimesulide    
COX-2, IC50: 0.07-70 μM
  99.70%
Ginsenoside Rd    
COX-2
  ≥98.0%
Diflunisal
COX
      ≥98.0%
Ginsenoside Rg5    
COX-2
  ≥99.0%
Ketorolac tromethamine salt  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
  99.94%
Paradol    
COX-2
  99.88%
Phenacetin      
COX-3, IC50: 102 μM
99.54%
ATB-346  
COX-1
COX-2
  98.35%
Imrecoxib  
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
  ≥99.0%
Guaiacol    
COX-2
  ≥97.0%
Bromfenac sodium hydrate  
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
  99.91%
Eicosatetraynoic acid
COX, ID50: 8 μM
      ≥99.0%
(+)-Catechin hydrate  
COX-1, IC50: 1.4 μM
    99.59%
Tolfenamic Acid    
COX-2, IC50: 13.49 μM (in cell)
  ≥98.0%
Fenbufen  
COX-1, IC50: 3.9 μM
COX-2, IC50: 8.1 μM
  98.99%
Mefenamic acid  
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
  99.97%
Licofelone
COX, IC50: 0.21 μM
      ≥99.0%
Madecassic acid    
COX-2
  98.34%
(-)-Catechin gallate  
COX-1
COX-2
  99.98%
Diclofenac diethylamine  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.93%
Fenoprofen Calcium hydrate
COX
      99.93%
Ginsenoside Rb3    
COX-2
  ≥99.0%
Valdecoxib  
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
  99.96%
SC-236  
COX-1, IC50: 17.8 μM
COX-2, IC50: 10 nM
  99.24%
Jaceosidin    
COX-2
  99.99%
Pectolinarigenin    
COX-2
  99.47%
[8]-Shogaol    
COX-2, IC50: 17.5 μM
  99.74%
Acemetacin  
COX-1, IC50: 85 μM (in human intact cell)
    99.97%
Macelignan    
COX-2
  ≥98.0%
Naproxen sodium  
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
  ≥98.0%
Adelmidrol    
COX-2
  ≥98.0%
γ-Tocopherol
Cyclooxygenase
      ≥98.0%
Syringaldehyde    
COX-2, IC50: 19.2 μM
  ≥98.0%
Parecoxib    
COX-2
  98.34%
Prim-O-glucosylcimifugin    
COX-2
  ≥98.0%
Etodolac  
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
  99.11%
Deracoxib    
COX-2
  99.77%
Psoralidin    
COX-2
  ≥99.0%
(S)-Flurbiprofen  
COX-1, IC50: 0.48 μM
COX-2, IC50: 0.47 μM
  99.83%
S-(+)-Ketoprofen  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.93%
Byakangelicol    
COX-2
  99.51%
Oxaprozin  
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
  99.76%
S-(+)-Marmesin    
COX-2
  99.11%
Asaraldehyde    
COX-2
  ≥98.0%
Hexahydrocurcumin    
COX-2
  99.70%
Pranoprofen  
COX-1
COX-2
  99.37%
Triflusal    
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
  99.64%
Lornoxicam  
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
  98.31%
Tenoxicam  
COX-1
COX-2
  99.94%
FK 3311    
COX-2
  98.38%
N-tert-Butyl-α-phenylnitrone    
COX-2
  ≥98.0%
Salicin
COX
      ≥99.0%
Harpagoside  
COX-1
COX-2
  98.35%
Tolmetin  
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
  ≥98.0%
Columbin  
COX-1, EC50: 327 μM
COX-2, EC50: 53.1 μM
  98.86%
Nepafenac  
COX-1, IC50: 64.3 μM
    99.51%
Firocoxib  
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
  98.42%
Parecoxib Sodium    
COX-2
  99.99%
Zaltoprofen  
COX-1, IC50: 1.3 μM
COX-2, IC50: 0.34 μM
  ≥98.0%
(S)-(+)-Ibuprofen  
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
  99.98%
Ampiroxicam
COX
      97.12%
Flunixin meglumine  
COX-1, IC50: 17 nM
COX-2, IC50: 0.4 nM
  99.65%
PTUPB  
COX-1, IC50: 1.26 μM
COX-1, IC50: 100 μM
    98.82%
β-Elemonic acid    
COX-2
  ≥99.0%
3,3'-Diiodo-L-thyronine
COX
      98.21%
2,5-Di-tert-butylhydroquinone    
COX-2, IC50: 14.1 μM
  ≥98.0%
Amfenac Sodium Hydrate    
COX-2
  98.65%
Mavacoxib    
COX-2
  99.83%
Tenidap  
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
  ≥99.0%
CAY10404  
COX-1, IC50: >500 μM
COX-2, IC50: 1 nM
  ≥99.0%
Bromfenac sodium  
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 
GW-406381    
COX-2
  ≥99.0%
TFAP  
COX-1, IC50: 0.8 μM
    99.97%
Ethyl Caffeate    
COX-2
  98.91%
Ampyrone
COX
      98.72%
Pamicogrel
Cyclooxygenase
      ≥99.0%
Propyphenazone
COX
      99.94%
Aceclofenac  
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
  99.75%
Gnetol  
COX-1, IC50: 0.78 μM
    ≥98.0%
Ketorolac D5  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
  ≥98.0%
(E)-Ethyl p-methoxycinnamate  
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
 
Alminoprofen    
COX-2
  99.35%
[10]-Shogaol    
COX-2, IC50: 7.5 μM
  99.78%
Isoxicam  
COX-1
COX-2
  99.11%
Cafestol    
COX-2
  99.91%
N-trans-Feruloyltyramine  
COX-1
COX-2
  98.64%
α-Spinasterol  
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
  99.15%
Phenidone
COX
      ≥98.0%
SC57666    
COX-2, IC50: 26 nM
  98.94%
FR-188582    
COX-2, IC50: 17 nM
  99.21%
Loxoprofen  
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
  99.76%
Tolmetin sodium dihydrate  
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
  99.77%
Inulicin    
COX-2
  99.42%
Nitroflurbiprofen
COX
      ≥99.0%
Diclofenac potassium  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
  ≥98.0%
Loxoprofen sodium  
COX-1, IC50: 6.5 μM
COX-2, IC50: 13.5 μM
  ≥98.0%
7,3',4'-Tri-O-methylluteolin    
COX-2
 
DuP-697  
hCOX-1, IC50: 800 nM
hCOX-2, IC50: 10 nM
 
AG-024322  
COX-1, Ki: 2.3 nM
COX-2, Ki: 3 nM
 
Roburic acid  
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
 
Mofezolac  
COX-1, IC50: 1.44 nM
COX-2, IC50: 447 nM
 
Nitroaspirin  
COX-1
   
Indomethacin-D4  
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 
Peonidin chloride    
COX-2
 
(S)-(+)-Ibuprofen D3  
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 
Taraxerol acetate  
COX-1, IC50: 116.3 μM
COX-2, IC50: 94.7 μM
 
Phenethyl ferulate
COX, IC50: 4.35 μM
     
Desmethyl Celecoxib    
COX-2, IC50: 32 nM
  99.09%
α-​Chaconine    
COX-2
 
Ermanin    
COX-2
 
α-Humulene    
COX-2
 
Sphondin    
COX-2
 
Anemarsaponin B    
COX-2
 
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone  
COX-1
COX-2
 
Pelubiprofen    
COX-2
 
Mefenamic acid D4  
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 nM
 
Hamaudol  
COX-1, IC50: 0.3 mM
COX-2, IC50: 0.57 mM
 
SC-58125  
hCOX-1, IC50: >100 μM
hCOX-2, IC50: 0.04 μM
 
Flurbiprofen axetil
COX
     
Salicylic acid-D6    
COX-2
 
Timegadine
COX, IC50: 5 nM (in rabbit platelets)
COX, IC50: 20 μM (in rat brain)
     
Indobufen
COX
      99.98%
Nimesulide D5    
COX-2, IC50: 0.07-70 μM
 
Ketorolac  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 
Fenoprofen Calcium
COX
     
LY 178002
Cyclooxygenase
     
RWJ 63556    
COX-2
 
Flosulide    
COX-2
 
Thioflosulide    
COX-2, IC50: 2.3 nM
 
S-2474  
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
 
Tilmacoxib    
Human COX-2, IC50: 85 nM
  ≥99.0%
COX/5-LO-IN-1
COX
     
SC58451    
COX-2
 
COX-2-IN-1    
COX-2, IC50: 3.9 μM
 
COX-2-IN-2    
COX-2, IC50: 240 nM