1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CXCR
  4. CXCR Inhibitors

CXCR Inhibitors

CXCR

CXCR1

CXCR2

CXCR3

CXCR4

CXCR7

CX3CR1

CXCR8

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CXCR Inhibitors, Agonists, Antagonists & Modulators
Product Name CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CX3CR1 CXCR8 Purity
Plerixafor        
125I-CXCL12-CXCR4, IC50: 44 nM
      >98.0%
Reparixin  
CXCR1wt, IC50: 5.6 nM (in L1.2 cells)
CXCR1Ile43Val, IC50: 80 nM (in L1.2 cells)
CXCR1, IC50: 1 nM (in cells)
CXCR2, IC50: ∼100 nM (in cells)
          99.98%
AMG 487      
125I-IP10-CXCR3, IC50: 8 nM
125I-ITAC-CXCR3, IC50: 8.2 nM
        99.65%
Plerixafor octahydrochloride        
125I-CXCL12-CXCR4, IC50: 44 nM
      >98.0%
Navarixin  
Cynomolgus CXCR1, Kd: 41 nM
Mouse CXCR2, Kd: 0.2 nM
Rat CXCR2, Kd: 0.2 nM
Cynomolgus CXCR2, Kd: 0.08 nM
          98.62%
USL311        
CXCR4
      99.97%
JMS-17-2            
CX3CR1, IC50: 0.32 nM
 
PS372424      
CXCR3
       
SB225002    
125I-IL-8-CXCR2, IC50: 22 nM (in CHO cell membrane)
          99.78%
AZD-5069    
125I-IL-8-CXCR2
          99.92%
LY2510924        
SDF-1α-CXCR4, IC50: 79.7 pM
SDF-1α-CXCR4, Ki: 49.5 pM
      99.91%
AZD8797    
125I-IL-8-CXCR2, Ki: 2800 nM (in HEK293S cells)
     
[125I]-CX3CL1-CX3CR1, Ki: 3.9 nM (in HEK293S cells)
  98.22%
Mavorixafor trihydrochloride        
125I-SDF-CXCR4, IC50: 13 nM
      99.14%
Motixafortide        
CXCR4, IC50: ∼1 nM
      99.19%
SCH 546738      
Human CXCR3, Ki: 0.4 nM
        99.20%
TAK-779      
mCXCR3, IC50: 369 nM (in PBMCs)
        99.73%
Baohuoside I        
CXCR4
      99.70%
IT1t dihydrochloride        
CXCL12/CXCR4, IC50: 2.1 nM
      98.09%
SCH 563705  
CXCR1, Ki: 3 nM
CXCR1, IC50: 7.3 nM
CXCR2, Ki: 1 nM
CXCR2, IC50: 1.3 nM
Mouse CXCR2, IC50: 5.2 nM
          95.34%
MSX-122        
CXCR4/CXCL12, IC50: ∼10 nM
      98.29%
Kynurenic acid              
CXCR8
98.75%
E6130            
CX3CR1
  >98.0%
Burixafor hydrobromide        
CXCR4
      >98.0%
Mavorixafor        
125I-SDF-CXCR4, IC50: 13 nM
     
SRT3190    
CXCR2
          99.61%
NBI-74330      
[125I]CXCL10-CXCR3, Ki: 1.5 nM (in CXCR3-CHO cell membranes)
[125I]CXCL11-CXCR3, Ki: 3.2 nM (in CXCR3-CHO cell membranes)
        >98.0%
CXCR2-IN-1    
CXCR2, pIC50: 9.3
          98.81%
IT1t        
CXCL12/CXCR4, IC50: 2.1 nM
     
ALX 40-4C Trifluoroacetate        
SDF-1-CXCR4, Ki: 1 μM
      98.15%
ALX 40-4C        
SDF-1-CXCR4, Ki: 1 μM
     
SRT3109    
CXCR2, pIC50: 8.2
          99.82%
UNBS5162
CXCL
              99.75%
CXCR7 modulator 2          
CXCR7, Ki: 13 nM
    >98.0%
GPR35 agonist 1              
CXCR8, EC50: 5.8 nM
Kynurenic acid sodium              
CXCR8
98.60%
CXCR7 modulator 1          
CXCR7, Ki: 9 nM
   
ATI-2341        
CXCR4, EC50: 194 nM (in CCRF-CEM cells)
     
ML 145              
CXCR8, IC50: 20.1 nM