1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CXCR
  4. CXCR Inhibitors

CXCR Inhibitors

CXCR

CXCR1

CXCR2

CXCR3

CXCR4

CXCR7

CXCR6

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CXCR Inhibitors, Agonists, Antagonists & Modulators
Product Name CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6 Purity
Plerixafor        
125I-CXCL12-CXCR4, IC50: 44 nM
    ≥98.0%
SB225002    
125I-IL-8-CXCR2, IC50: 22 nM (in CHO cell membrane)
        99.78%
AMG 487      
125I-IP10-CXCR3, IC50: 8 nM
125I-ITAC-CXCR3, IC50: 8.2 nM
      99.65%
Navarixin  
Cynomolgus CXCR1, Kd: 41 nM
125I-CXCL8-CXCR1, IC50: 43 nM
Mouse CXCR2, Kd: 0.2 nM
Rat CXCR2, Kd: 0.2 nM
Cynomolgus CXCR2, Kd: 0.08 nM
125I-CXCL8-CXCR2, IC50: 0.97 nM
        99.13%
Reparixin  
CXCR1wt, IC50: 5.6 nM (in L1.2 cells)
CXCR1Ile43Val, IC50: 80 nM (in L1.2 cells)
CXCR1, IC50: 1 nM (in cells)
CXCR2, IC50: ∼100 nM (in cells)
        99.98%
CXCR2-IN-2  
CXCR1, IC50: 3.8 μM
CXCR2, IC50: 5.2 nM
        98.45%
KRH-3955 hydrochloride        
SDF-1α-CXCR4, IC50: 0.61 nM
   
CXCR7 modulator 2          
CXCR7, Ki: 13 nM
  ≥98.0%
AZD-5069    
125I-IL-8-CXCR2
        99.92%
Plerixafor octahydrochloride        
125I-CXCL12-CXCR4, IC50: 44 nM
    ≥98.0%
AZD8797    
125I-IL-8-CXCR2, Ki: 2800 nM (in HEK293S cells)
        98.65%
Motixafortide        
CXCR4, IC50: ~1 nM
    98.27%
Mavorixafor trihydrochloride        
125I-SDF-CXCR4, IC50: 13 nM
    ≥98.0%
TAK-779      
mCXCR3, IC50: 369 nM (in PBMCs)
      ≥98.0%
SX-682  
CXCR1
CXCR2
        98.52%
IT1t dihydrochloride        
CXCL12/CXCR4, IC50: 2.1 nM
    99.97%
SCH 546738      
Human CXCR3, Ki: 0.4 nM
      99.23%
NUCC-390 dihydrochloride        
CXCR4
    99.59%
Reparixin L-lysine salt  
CXCR1wt, IC50: 5.6 nM (in L1.2 cells)
CXCR1Ile43Val, IC50: 80 nM (in L1.2 cells)
CXCR1, IC50: 1 nM (in cells)
CXCR2, IC50: ∼100 nM (in cells)
        99.97%
Burixafor hydrobromide        
CXCR4
    ≥98.0%
Baohuoside I        
CXCR4
    99.70%
NBI-74330      
[125I]CXCL10-CXCR3, Ki: 1.5 nM (in CXCR3-CHO cell membranes)
[125I]CXCL11-CXCR3, Ki: 3.2 nM (in CXCR3-CHO cell membranes)
      99.23%
Danirixin    
CXCL8-CXCR2, IC50: 12.5 nM
        98.21%
WZ811        
CXCR4, EC50: 0.3 nM
    ≥99.0%
LY2510924        
125I-SDF-1α-CXCR4, IC50: 79.7 pM
125I-SDF-1α-CXCR4, Ki: 49.5 pM
    ≥98.0%
USL311        
CXCR4
    99.97%
Balixafortide TFA        
CXCR4, IC50: <10 nM
    98.19%
CXCR2-IN-1    
CXCR2, pIC50: 9.3
        99.26%
MSX-122        
CXCR4/CXCL12, IC50: ~10 nM
    98.29%
AMD 3465 hexahydrobromide        
12G5 mAb-CXCR4, IC50: 0.75 nM (in SupT1 cells)
CXCL12AF647-CXCR4, IC50: 18 nM (in SupT1 cells)
    ≥98.0%
SCH 563705  
CXCR1, Ki: 3 nM
CXCR1, IC50: 7.3 nM
CXCR2, Ki: 1 nM
CXCR2, IC50: 1.3 nM
Mouse CXCR2, IC50: 5.2 nM
        98.20%
ALX 40-4C Trifluoroacetate        
SDF-1-CXCR4, Ki: 1 μM
    95.90%
FC131 TFA        
125I-SDF-1-CXCR4, IC50: 4.5 nM
    99.87%
SRT3109    
CXCR2, pIC50: 8.2
        99.82%
Elubrixin tosylate    
CXCR2
        99.74%
PS372424 hydrochloride      
Human CXCR3
      ≥98.0%
VUF11207 fumarate          
CXCR7, pKi: 8.1
  98.50%
SRT3190    
CXCR2
        99.32%
UNBS5162
CXCL
            99.92%
Nicotinamide N-oxide    
CXCR2
        99.93%
CXCR7 modulator 1          
CXCR7, Ki: 9 nM
  99.67%
IT1t        
CXCL12/CXCR4, IC50: 2.1 nM
   
ALX 40-4C        
SDF-1-CXCR4, Ki: 1 μM
   
NUCC-390        
CXCR4
   
SB-265610    
CXCR2
        ≥99.0%
PS372424      
Human CXCR3
     
Mavorixafor        
125I-SDF-CXCR4, IC50: 13 nM
   
AMG 487 (S-enantiomer)      
CXCR3
      98.92%
AMD 3465        
12G5 mAb-CXCR4, IC50: 0.75 nM (in SupT1 cells)
CXCL12AF647-CXCR4, IC50: 18 nM (in SupT1 cells)
   
Balixafortide        
CXCR4, IC50: <10 nM
   
Elubrixin    
CXCR2
       
ML339            
CXCR6, IC50: 140 nM
MSX-127        
CXCR4
   
TC14012        
CXCR4, IC50: 19.3 nM (antagonist site)
CXCR7, EC50: 350 nM (agonist site)
 
CTCE-9908        
CXCR4
   
ATI-2341        
CXCR4, EC50: 194 nM (in CCRF-CEM cells)
   
Corydalmine    
CXCR2
       
CXCR4 antagonist 1        
CXCR4
   
MSX-130        
CXCR4
   
FC131        
125I-SDF-CXCR4, IC50: 4.5 nM