Signaling Pathway

CaMK-II

CaMK-II

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CaMK-II (Ca2+/calmodulin-dependent protein kinase II) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cellactivation. Misregulation of CaMKII is linked to Alzheimer’s disease, Angelman syndrome, and heart arrhythmia. There are two types of CaM kinase: Specialized CaM kinases, such as the myosin light chain kinase that phosphorylates myosin, causing smooth muscles to contract. Multifunctional CaM kinases, also collectively called CaM kinase II, which play a role in neurotransmitter secretion, transcription factor regulation, and glycogen metabolism.

CaMK-II Inhibitors & Modulators (8)

Product Name Catalog No. Brief Description
CaMKII-IN-1

HY-18271

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.

KN-62

HY-13290

KN-62 is selective, cell-permeable inhibitor of CaM kinase II (IC50 = 0.9 μM);  binds directly to the calmodulin binding site of the enzyme; potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

KN-92

HY-15517

KN-92 is an inactive derivative of KN-93.

KN-92 hydrochloride

HY-15517B

KN-92 is an inactive derivative of KN-93.

KN-92 phosphate

HY-15517A

KN-92 is an inactive derivative of KN-93.

KN-93

HY-15465

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

KN-93 hydrochloride

HY-15465A

KN-93 Hcl is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

KN-93 phosphate

HY-15465B

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).