1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. Checkpoint Kinase (Chk) Inhibitors

Checkpoint Kinase (Chk) Inhibitors

Chk1

Chk2

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Checkpoint Kinase (Chk) Inhibitors & Activators
Product Name Chk1 Chk2 Purity
Prexasertib
Chk1, IC50: <1 nM
Chk1, Ki: 0.9 nM
Chk2, IC50: 8 nM
98.22%
AZD-7762
Chk1, IC50: 5 nM
Chk2, IC50: 5 nM
99.95%
Rabusertib
Chk1, IC50: 7 nM
Chk2, IC50: 12000 nM
99.69%
Prexasertib dihydrochloride
Chk1, IC50: <1 nM
Chk1, Ki: 0.9 nM
Chk2, IC50: 8 nM
99.41%
CCT245737
Chk1, IC50: 1.3 nM
Chk2, IC50: 2440 nM
99.24%
CCT241533 hydrochloride
Chk1, IC50: 245 nM
Chk2, IC50: 3 nM
99.98%
PD 407824
Chk1, IC50: 47 nM
  >98.0%
CCT241533
Chk1, IC50: 245 nM
Chk2, IC50: 3 nM
SCH900776
Chk1, IC50: 3 nM
Chk2, IC50: 1500 nM
99.97%
CHIR-124
Chk1, IC50: 0.3 nM
Chk2, IC50: 697.4 nM
98.07%
CCT244747
Chk1, IC50: 7.7 nM
  >99.0%
BML-277  
Chk2, IC50: 15 nM
98.02%
PF 477736
Chk1, Ki: 0.49 nM
Chk2, Ki: 47 nM
98.07%
GDC-0575 dihydrochloride
Chk1, IC50: 1.2 nM
  99.83%
Prexasertib Mesylate Hydrate
Chk1, IC50: <1 nM
Chk1, Ki: 0.9 nM
Chk2, IC50: 8 nM
ANI-7  
Chk2
99.25%
CHK1-IN-4
Chk1
 
CHK1-IN-2
Chk1, IC50: 6 nM
 
CHK1-IN-3
Chk1, IC50: 0.4 nM
 
VER-00158411
Chk1, IC50: 4.4 nM
Chk2, IC50: 4.5 nM
SB-218078
Chk1, IC50: 15 nM
  >98.0%
CHK-IN-1
Chk1
Chk2