1. Signaling Pathways
  2. Epigenetics
  3. DNA Methyltransferase
  4. DNA Methyltransferase Inhibitors

DNA Methyltransferase Inhibitors

DNA Methyltransferase

DNMT1

DNMT3

MGMT

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

DNA Methyltransferase Inhibitors
Product Name DNA Methyltransferase DNMT1 DNMT3 MGMT Purity
Decitabine  
DNMT1
DNMT3A
DNMT3B
  ≥95.0%
5-Azacytidine  
DNMT1
    ≥98.0%
RG108  
CpG methylase M.SssI, IC50: 115 nM
    99.81%
SGI-1027  
DNMT1, IC50: 12.5 μM
DNMT3B, IC50: 7.5 μM
DNMT3A, IC50: 8 μM
  99.92%
CM-579
DNA Methyltransferase, IC50: 32 nM
DNMT1, Kd: 1.5 nM
DNMT3A, IC50: 92 nM
DNMT3B, IC50: 1000 nM
 
Zebularine  
DNMT1
DNMT3a/3L
  ≥98.0%
CM-272  
DNMT1, IC50: 382 nM
DNMT3A, IC50: 85 nM
DNMT3B, IC50: 1200 nM
  98.13%
GSK-3484862  
DNMT1
    99.94%
Guadecitabine sodium  
DNMT1
    98.05%
Hinokitiol  
DNMT1
    ≥98.0%
Lomeguatrib      
MGMT, IC50: 9 nM
MGMT, IC50: 6 nM (in MCF-7 cells)
≥98.0%
γ-Oryzanol  
DNMT1, IC50: 3.2 μM
DNMT3A, IC50: 22.3 μM
  ≥95.0%
CM-579 trihydrochloride
DNA Methyltransferase, IC50: 32 nM
DNMT1, Kd: 1.5 nM
DNMT3A, IC50: 92 nM
DNMT3B, IC50: 1000 nM
  98.03%
DC_517  
DNMT1, Kd: 0.91 μM
DNMT1, IC50: 1.7 μM
    99.66%
DC-05  
DNMT1, Kd: 1.09 μM
DNMT1, IC50: 10.3 μM
    99.08%
Nanaomycin A    
DNMT3B, IC50: 500 nM
  ≥98.0%
O6BTG-octylglucoside      
MGMT, IC50: 32 nM
≥95.0%
Guadecitabine
DNA Methyltransferase
      98.0%
Isofistularin-3  
DNMT1, IC50: 13.5 μM
   
5-Aza-4'-thio-2'-deoxycytidine  
DNMT1