1. Signaling Pathways
  2. Epigenetics
  3. DNA Methyltransferase
  4. DNA Methyltransferase Inhibitors

DNA Methyltransferase Inhibitors

DNA Methyltransferase

DNMT1

DNMT3

MGMT

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

DNA Methyltransferase Inhibitors
Product Name DNA Methyltransferase DNMT1 DNMT3 MGMT Purity
5-Azacytidine  
DNMT1
    99.97%
SGI-1027  
DNMT1, IC50: 12.5 μM
DNMT3B, IC50: 7.5 μM
DNMT3A, IC50: 8 μM
  99.77%
Guadecitabine sodium  
DNMT1
    98.06%
Zebularine  
DNMT1
DNMT3a/3L
  99.92%
CM-579 trihydrochloride
DNA Methyltransferase, IC50: 32 nM
DNMT1, Kd: 1.5 nM
DNMT3A, IC50: 92 nM
DNMT3B, IC50: 1000 nM
  98.03%
CM-579
DNA Methyltransferase, IC50: 32 nM
DNMT1, Kd: 1.5 nM
DNMT3A, IC50: 92 nM
DNMT3B, IC50: 1000 nM
 
Lomeguatrib      
MGMT, IC50: 9 nM
MGMT, IC50: 6 nM (in MCF-7 cells)
97.95%
Hinokitiol  
DNMT1
    99.28%
Guadecitabine
DNA Methyltransferase
      98.00%
γ-Oryzanol  
DNMT1, IC50: 3.2 μM
DNMT3A, IC50: 22.3 μM
  >95.0%
DC_517  
DNMT1, Kd: 0.91 μM
DNMT1, IC50: 1.7 μM
    99.66%
DC-05  
DNMT1, Kd: 1.09 μM
DNMT1, IC50: 10.3 μM
    99.15%
Glucose-conjugated MGMT inhibitor      
MGMT, IC50: 32 nM
>95.0%