1. GPCR/G Protein
  2. Glucagon Receptor

Glucagon Receptor

Glucagon receptor is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

Glucagon Receptor Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-13443
    Exendin-4 Activator
    Exendin-4(Exenatide), a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors.
  • HY-P0014
    Liraglutide Agonist
    Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.
  • HY-50663
    MK 0893 Antagonist
    MK 0893 is a potent, selective glucagon receptor antagonist with IC50 of 6.6 nM, and > 200 fold selectivity against GIPR, PAC1, GLP-1R, VPAC1 and VPAC2.
  • HY-50158
    glucagon receptor antagonists-2 Antagonist
    Glucagon receptor antagonists-2 is a highly potent glucagon receptor antagonist.
  • HY-19947
    glucagon receptor antagonists-4 Antagonist
    glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist.
  • HY-13443A
    Exendin-4 Acetate Activator
    Exendin-4(Exenatide) Acetate is a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors.
  • HY-P0055
    GLP-17-37 Inhibitor
    GLP-1(7-37) is an insulinotropic peptide generated from the precursor peptide GLP-1(1-37).
  • HY-P0165
    Taspoglutide Agonist
    Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC50 value of 0.06 nM.
  • HY-19904
    Adomeglivant Antagonist
    Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus.
  • HY-50159
    glucagon receptor antagonists-3 Antagonist
    Glucagon receptor antagonists-3 is a highly potent glucagon receptor antagonist.
  • HY-P0119
    Lixisenatide Inhibitor
    Lixisenatide inhibit glucagon release, markedly reduce postprandial glucago. have a promoting effct in diabetes mellitus (T2DM).
  • HY-10036
    glucagon receptor antagonists-1 Antagonist
    Glucagon receptor antagonists-1 is a highly potent glucagon receptor antagonist.
  • HY-50675
    GRA Ex-25 Inhibitor
    GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.