Signaling Pathway

HBV

HBV

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Hepatitis B virus, abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.

HBV Inhibitors, Modulators

HBV(13)

Product Name Catalog No. Brief Description
Adefovir dipivoxil

HY-B0255

Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

Bay 41-4109 racemate

HY-100029A

BAY 41-4109 racemate is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.

Bicyclol

HY-B0766

Bicyclol(SY 801) is a anti-hepatitis drug.

Clevudine

HY-13859

Clevudine is an antiviral drug for the treatment of hepatitis B.

Entecavir

HY-13623

Entecavir(BMS200475; SQ34676) is a guanosine analogue that inhibits reverse transcription, DNA replication and transcription in the viral replication process; oral antiHBV drug.

Entecavir monohydrate

HY-13623A

Entecavir monohydrate(SQ 34676; BMS 200475) is a nucleoside analog that inhibits reverse transcription; entecavir is used to treat chronic hepatitis B.

Helioxanthin 8-1

HY-16680

Helioxanthin 8-1 is an analogue of  helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.

Helioxanthin derivative 5-4-2

HY-16679

Helioxanthin derivative 5-4-2 is an analogue of  helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.

Lagociclovir

HY-14844

Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.

Merimepodib

HY-13986

Merimepodiba(VX-497) is a novel noncompetitive inhibitor of IMPDH(Inosine monophosphate dehydrogenase).

Oxethazaine

HY-B0955

Oxethazaine is a topical anesthetic, in preventing acid-induced esophageal pain.

Squalamine

HY-16468

Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity.

Telbivudine

HY-B0017

Telbivudine, a specific inhibitor of hepatitis B virus (HBV) replication, is an antiviral drug used in the treatment of hepatitis B infection.