1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC Inhibitors

HDAC Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

HDAC Inhibitors, Activators & Modulators
Product Name HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2 Purity
Trichostatin A
HDAC, IC50: 1.8 nM
                          ≥98.0%
Vorinostat  
HDAC1, ID50: 10 nM
 
HDAC3, ID50: 20 nM
                    ≥95.0%
Panobinostat
HDAC
                          ≥98.0%
4-Phenylbutyric acid
HDAC
                          ≥97.0%
Valproic acid
HDAC, IC50: 0.5-2 mM
HDAC1, IC50: 400 μM
                        ≥98.0%
KA2507  
HDAC1, IC50: 9895 nM
   
HDAC4, IC50: 9613 nM
HDAC5, IC50: 1997 nM
HDAC6, IC50: 2.5 nM
HDAC7, IC50: 2333 nM
HDAC8, IC50: 621
HDAC9, IC50: 5648 nM
       
Pomiferin
HDAC, IC50: 1.05 μM
                          97.36%
Entinostat  
HDAC1, IC50: 243 nM
HDAC2, IC50: 453 nM
HDAC3, IC50: 248 nM
                    99.65%
Sulforaphane
HDAC
                          ≥98.0%
Romidepsin  
HDAC1, IC50: 36 nM
HDAC2, IC50: 47 nM
 
HDAC4, IC50: 510 nM
 
HDAC6, IC50: 14000 nM
              99.98%
Sodium 4-phenylbutyrate
HDAC
                          99.80%
Ricolinostat  
HDAC1, IC50: 58 nM
HDAC2, IC50: 48 nM
HDAC3, IC50: 51 nM
HDAC4, IC50: 7000 nM
HDAC5, IC50: 5000 nM
HDAC6, IC50: 4.7 nM
HDAC7, IC50: 1400 nM
HDAC8, IC50: 100 nM
          ≥95.0%
Tucidinostat  
HDAC1, IC50: 95 nM
HDAC2, IC50: 160 nM
HDAC3, IC50: 67 nM
       
HDAC8, IC50: 733 nM
 
HDAC10, IC50: 78 nM
HDAC11, IC50: 432 nM
    ≥98.0%
Belinostat
HDAC, IC50: 27 nM (Hela cell)
         
HDAC6, IC50: 82 nM
              99.94%
RGFP966      
HDAC3, IC50: 80 nM
                    99.81%
Valproic acid sodium salt
HDAC, IC50: 0.5-2 mM
HDAC1, IC50: 400 μM
                        ≥98.0%
Fimepinostat  
HDAC1, IC50: 1.7 nM
HDAC2, IC50: 5 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC6, IC50: 27 nM
HDAC7, IC50: 426 nM
HDAC8, IC50: 191 nM
HDAC9, IC50: 554 nM
HDAC10, IC50: 2.8 nM
HDAC11, IC50: 5.4 nM
    99.95%
Tubastatin A  
HDAC1, IC50: 16400 nM
       
HDAC6, IC50: 15 nM
 
HDAC8, IC50: 854 nM
          ≥98.0%
Tasquinimod        
HDAC4, Kd: 10-30 nM
                  ≥95.0%
Mocetinostat  
HDAC1, IC50: 0.15 μM
HDAC2, IC50: 0.29 μM
HDAC3, IC50: 1.66 μM
             
HDAC11, IC50: 0.59 μM
    99.43%
Quisinostat  
HDAC1, IC50: 0.11 nM
HDAC2, IC50: 0.33 nM
HDAC3, IC50: 4.86 nM
HDAC4, IC50: 0.64 nM
HDAC5, IC50: 3.69 nM
HDAC6, IC50: 76.8 nM
HDAC7, IC50: 119 nM
HDAC8, IC50: 4.26 nM
HDAC9, IC50: 32.1 nM
HDAC10, IC50: 0.46 nM
HDAC11, IC50: 0.37 nM
    98.02%
TMP269        
HDAC4, IC50: 157 nM
HDAC5, IC50: 97 nM
HDAC6, IC50: 82000 nM
HDAC7, IC50: 43 nM
HDAC8, IC50: 42000 nM
HDAC9, IC50: 23 nM
        98.74%
TMP195        
HDAC4, IC50: 111 nM
HDAC5, IC50: 106 nM
HDAC6, IC50: 47800 nM
HDAC7, IC50: 46 nM
HDAC8, IC50: 11700 nM
HDAC9, IC50: 9 nM
        99.68%
PCI-34051  
HDAC1, IC50: 4 μM
       
HDAC6, IC50: 2.9 μM
 
HDAC8, IC50: 10 nM
 
HDAC10, IC50: 13 μM
      99.38%
Tubacin  
HDAC1, IC50: 1.40 μM
HDAC2, IC50: 6.27 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC6, IC50: 4 nM
HDAC7, IC50: 9.70 μM
HDAC8, IC50: 1.27 μM
HDAC9, IC50: 4.31 μM
HDAC10, IC50: 3.71 μM
HDAC11, IC50: 3.79 μM
    99.17%
Tacedinaline  
HD1, IC50: 0.9 μM
HD2, IC50: 0.9 μM
HD3, IC50: 1.2 μM
                    99.51%
ACY-738  
HDAC1, IC50: 94 nM
HDAC2, IC50: 128 nM
HDAC3, IC50: 218 nM
   
HDAC6, IC50: 1.7 nM
              98.75%
FT895                      
HDAC11, IC50: 3 nM
    99.93%
CUDC-101
HDAC, IC50: 4.4 nM
HDAC1, IC50: 4.5 nM
HDAC2, IC50: 12.6 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC6, IC50: 5.1 nM
HDAC7, IC50: 373 nM
HDAC8, IC50: 79.8 nM
HDAC9, IC50: 67.2 nM
HDAC10, IC50: 26.1 nM
      99.02%
Dacinostat
HDAC, IC50: 32 nM
HDAC1, IC50: 9 nM
                        ≥98.0%
ITSA-1
HDAC
                          ≥98.0%
Santacruzamate A    
HDAC2, IC50: 119 pM
     
HDAC6, IC50: 434 nM
              99.32%
Pracinostat  
HDAC1, IC50: 49 nM
HDAC2, IC50: 96 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC6, IC50: 1008 nM
HDAC7, IC50: 137 nM
HDAC8, IC50: 140 nM
HDAC9, IC50: 70 nM
HDAC10, IC50: 40 nM
HDAC11, IC50: 93 nM
    99.07%
RG2833  
HDAC1, IC50: 60 nM
HDAC1, Ki: 32 nM
 
HDAC3, IC50: 50 nM
HDAC3, Ki: 5 nM
                    99.71%
Tubastatin A Hydrochloride  
HDAC1, IC50: 16400 nM
       
HDAC6, IC50: 15 nM
 
HDAC8, IC50: 854 nM
          ≥95.0%
MC1568
HDAC
                          96.64%
Nexturastat A  
HDAC1, IC50: 3.02 μM
HDAC2, IC50: 6.92 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC6, IC50: 5.02 nM
HDAC7, IC50: 4.46 μM
HDAC8, IC50: 0.954 μM
HDAC9, IC50: 6.72 μM
HDAC10, IC50: 7.57 μM
HDAC11, IC50: 5.14 μM
    98.49%
Abexinostat  
HDAC1, Ki: 7 nM
HDAC2, Ki: 19 nM
HDAC3/SMRT, Ki: 8.2 nM
   
HDAC6, Ki: 17 nM
 
HDAC8, Ki: 280 nM
 
HDAC10, Ki: 24 nM
      98.61%
CAY10603  
HDAC1, IC50: 271 nM
HDAC2, IC50: 252 nM
HDAC3, IC50: 0.42 nM
   
HDAC6, IC50: 0.002 nM
 
HDAC8, IC50: 6851 nM
 
HDAC10, IC50: 90.7 nM
      95.39%
WT-161  
HDAC1, IC50: 8.35 nM
HDAC2, IC50: 15.4 nM
HDAC3, IC50: 51.6 nM
   
HDAC6, IC50: 0.4 nM
 
HDAC8, IC50: 1430 nM
          98.52%
SW-100  
HDAC1, IC50: 5.23 μM
HDAC2, IC50: 32.8 μM
HDAC3, IC50: 29.5 μM
HDAC4, IC50: 10.9 μM
HDAC5, IC50: 4.07 μM
HDAC6, IC50: 2.3 nM
HDAC7, IC50: 4.55 μM
HDAC8, IC50: 3.72 μM
HDAC9, IC50: 3.46 μM
HDAC10, IC50: 26.2 μM
HDAC11, IC50: 5.72 μM
    99.92%
Givinostat hydrochloride monohydrate  
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
≥98.0%
Citarinostat  
HDAC1, IC50: 35 nM
HDAC2, IC50: 45 nM
HDAC3, IC50: 46 nM
   
HDAC6, IC50: 2.6 nM
HDAC7, IC50: 7300 nM
HDAC8, IC50: 137 nM
          ≥95.0%
ACY-957  
HDAC1, IC50: 7 nM
HDAC2, IC50: 18 nM
HDAC3, IC50: 1300 nM
                    99.91%
J22352            
HDAC6, IC50: 4.7 nM
              99.73%
ACY-1083            
HDAC6, IC50: 3 nM
              99.43%
Scriptaid
HDAC
                          98.59%
BRD-6929  
HDAC1, IC50: 1 nM
HDAC2, IC50: 8 nM
HDAC3, IC50: 458 nM
                    ≥99.0%
Bufexamac      
HDAC3, Kd app: 341 μM
   
HDAC6, Kd app: 10.7 μM
 
HDAC8, Kd app: 235 μM
 
HDAC10, Kd app: 12.3 μM
      ≥98.0%
HDAC8-IN-1                
HDAC8, IC50: 27.2 nM
          99.82%
Sinapinic acid
HDAC, IC50: 2.27 mM
                          99.61%
Domatinostat  
HDAC-1, IC50: 1.2 μM
HDAC-2, IC50: 1.12 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-10, IC50: 21 μM
HDAC-11, IC50: 9.7 μM
    99.08%
EDO-S101  
HDAC1, IC50: 9 nM
HDAC2, IC50: 9 nM
HDAC3, IC50: 25 nM
   
HDAC6, IC50: 6 nM
 
HDAC8, IC50: 107 nM
 
HDAC10, IC50: 72 nM
      ≥98.0%
BRD 4354          
HDAC5, IC50: 0.85 μM
     
HDAC9, IC50: 1.88 μM
        98.29%
BML-210        
HDAC4:MEF2
                  96.38%
Resminostat hydrochloride  
HDAC1, IC50: 42.5 nM
 
HDAC3, IC50: 50.1 nM
   
HDAC6, IC50: 71.8 nM
 
HDAC8, IC50: 877 nM
          98.40%
ACY-775  
HDAC1, IC50: 2123 nM
HDAC2, IC50: 2570 nM
HDAC3, IC50: 11223 nM
   
HDAC6, IC50: 7.5 nM
              99.83%
JAK/HDAC-IN-1
HDAC, IC50: 2 nM
 
HDAC2, IC50: 14 nM
     
HDAC6, IC50: 120 nM
 
HDAC8, IC50: 2470 nM
          98.04%
CXD101  
HDAC1, IC50: 63 nM
HDAC2, IC50: 570 nM
HDAC3, IC50: 550 nM
                    99.14%
M344
HDAC, IC50: 100 nM
                          99.28%
HDACs/mTOR Inhibitor 1  
HDAC1, IC50: 0.19 nM
       
HDAC6, IC50: 1.8 nM
              99.12%
Droxinostat      
HDAC3, IC50: 16.9 μM
   
HDAC6, IC50: 2.47 μM
 
HDAC8, IC50: 1.46 μM
          99.60%
BG45  
HDAC1, IC50: 2.0 μM
HDAC2, IC50: 2.2 μM
HDAC3, IC50: 0.289 μM
                    99.95%
BRD 4354 ditrifluoroacetate          
HDAC5, IC50: 0.85 μM
     
HDAC9, IC50: 1.88 μM
        98.06%
Tefinostat
HDAC
                          98.08%
Pimelic Diphenylamide 106  
HDAC1, IC50: 150 nM
HDAC2, IC50: 760 nM
HDAC3, IC50: 370 nM
       
HDAC8, IC50: 5000 nM
          ≥98.0%
BRD3308  
HDAC1, IC50: 1260 nM
HDAC1, Ki: 5100 nM
HDAC2, IC50: 1340 nM
HDAC2, Ki: 6300 nM
HDAC3, IC50: 54 nM
HDAC3, Ki: 29 nM
                    95.94%
Splitomicin
Sir2p, IC50: 60 μM
                          98.42%
TH34            
HDAC6, IC50: 4.6 μM
 
HDAC8, IC50: 1.9 μM
 
HDAC10, IC50: 7.7 μM
      99.05%
BRD73954    
HDAC2, IC50: 9 μM
     
HDAC6, IC50: 0.036 μM
 
HDAC8, IC50: 0.12 μM
          ≥98.0%
UF010  
HDAC1, IC50: 0.5 μM
HDAC2, IC50: 0.1 μM
HDAC3, IC50: 0.06 μM
   
HDAC6, IC50: 9.1 μM
 
HDAC8, IC50: 1.5 μM
 
HDAC10, IC50: 15.3 μM
HDAC11, IC50: 44.5 μM
    99.08%
Domatinostat tosylate  
HDAC-1, IC50: 1.2 μM
HDAC-2, IC50: 1.12 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-10, IC50: 21 μM
HDAC-11, IC50: 9.7 μM
    99.66%
HPOB  
HDAC1, IC50: 2.9 μM
HDAC2, IC50: 4.4 μM
HDAC3/NCOR2, IC50: 1.7 μM
   
HDAC6, IC50: 0.056 μM
 
HDAC8, IC50: 2.8 μM
 
HDAC10, IC50: 3.0 μM
      ≥95.0%
SR-4370  
HDAC1, IC50: 130 nM
HDAC2, IC50: 580 nM
HDAC3, IC50: 6 nM
   
HDAC6, IC50: 3400 nM
 
HDAC8, IC50: 2300 nM
          98.03%
HDAC-IN-3
HDAC
                          98.86%
Oxamflatin
HDAC, IC50: 15.7 nM
                          ≥98.0%
Suberoyl bis-hydroxamic acid  
HDAC1, IC50: 0.25 μM
 
HDAC3, IC50: 0.30 μM
                    ≥98.0%
Crotonoside      
HDAC3
   
HDAC6
              ≥98.0%
1-Naphthohydroxamic acid  
HDAC1, IC50: >100 μM
       
HDAC6, IC50: >100 μM
 
HDAC8, IC50: 14 μM
          ≥98.0%
NKL 22  
HDAC1, IC50: 0.199 μM
HDAC2, IC50: 1.59 μM
HDAC3, IC50: 0.069 μM
       
HDAC8, IC50: 5 μM
          97.97%
PTACH  
HDAC1, IC50: 48 nM
   
HDAC4, IC50: 32 nM
 
HDAC6, IC50: 41 nM
              99.65%
SS-208  
HDAC1, IC50: 1.39 μM
     
HDAC5, IC50: 6.91 μM
HDAC6, IC50: 12 nM
HDAC7, IC50: 8.34 μM
HDAC8, IC50: 1.23 μM
   
HDAC11, IC50: 5.12 μM
    98.13%
CHDI-390576  
HDAC1, IC50: 39.7 μM
 
HDAC3, IC50: 25.8 μM
HDAC4, IC50: 54 nM
HDAC5, IC50: 60 nM
hHDAC6, IC50: 6.2 μM
HDAC7, IC50: 31 nM
HDAC8, IC50: 9.1 μM
hHDAC9, IC50: 50 nM
        ≥98.0%
Givinostat  
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Resminostat  
HDAC1, IC50: 42.5 nM
 
HDAC3, IC50: 50.1 nM
   
HDAC6, IC50: 71.8 nM
 
HDAC8, IC50: 877 nM
         
Quisinostat dihydrochloride  
HDAC1, IC50: 0.11 nM
HDAC2, IC50: 0.33 nM
HDAC3, IC50: 4.86 nM
 
HDAC5, IC50: 3.69 nM
HDAC6, IC50: 76.8 nM
HDAC7, IC50: 119 nM
HDAC8, IC50: 4.26 nM
HDAC9, IC50: 32.1 nM
HDAC10, IC50: 0.46 nM
HDAC11, IC50: 0.37 nM
   
CG-200745
HDAC
                         
MPT0G211 mesylate            
HDAC6, IC50: 0.291 μM
             
MPT0E028  
HDAC1, IC50: 53.0 nM
HDAC2, IC50: 106.2 nM
     
HDAC6, IC50: 29.5 nM
 
HDAC8, IC50: 2532.6 nM
         
IDO1 and HDAC1 Inhibitor  
HDAC1, IC50: 66.5 nM
                       
AES-135      
HDAC3, IC50: 654 nM
   
HDAC6, IC50: 190 nM
 
HDAC8, IC50: 1100 nM
   
HDAC11, IC50: 636 nM
    98.31%
PI3K/HDAC-IN-1  
HDAC1, IC50: 1.4 nM
HDAC2, IC50: 3.0 nM
     
HDAC6, IC50: 6.6 nM
 
HDAC8, IC50: 18 nM
         
MPT0G211            
HDAC6, IC50: 0.291 μM
             
FNDR-20123
human HDAC, IC50: 3 nM
Plasmodium HDAC, IC50: 31 nM
HDAC1, IC50: 25 nM
HDAC2, IC50: 29 nM
HDAC3, IC50: 2 nM
   
HDAC6, IC50: 11 nM
 
HDAC8, IC50: 282 nM
          98.08%
AES-350      
HDAC3, IC50: 187 nM
   
HDAC6, IC50: 24.4 nM
       
HDAC11, IC50: 245 nM
   
CM-675  
HDAC1, IC50: 673 nM (30 min (time-dependent))
                       
FNDR-20123 free base
human HDAC, IC50: 3 nM
Plasmodium HDAC, IC50: 31 nM
HDAC1, IC50: 25 nM
HDAC2, IC50: 29 nM
HDAC3, IC50: 2 nM
   
HDAC6, IC50: 11 nM
 
HDAC8, IC50: 282 nM
         
Chlamydocin
HDAC, IC50: 1.3 nM
                         
Tucidinostat D4  
HDAC1, IC50: 95 nM
HDAC2, IC50: 160 nM
HDAC3, IC50: 67 nM
           
HDAC10, IC50: 78 nM
     
QTX125            
HDAC6
             
Pivanex
HDAC
                         
Givinostat hydrochloride  
hHDAC1, IC50: 198 nM
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
CRA-026440  
HDAC1, Ki: 4 nM
HDAC2, Ki: 14 nM
HDAC3, Ki: 11 nM
   
HDAC6, Ki: 15 nM
 
HDAC8, Ki: 7 nM
 
HDAC10, Ki: 20 nM