1. Signaling Pathways
  2. Cytoskeleton
  3. Integrin
  4. Integrin Inhibitors

Integrin Inhibitors

αvβ1

αvβ3

αvβ5

αvβ6

αvβ8

α5β1

α2β1

α4β1

α9β1

αIIbβ3

α4β7

αLβ2

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Integrin Inhibitors, Agonists & Antagonists
Product Name αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2 Purity
Cilengitide  
αvβ3, IC50: 4 nM (Binds to Vitronectin)
αvβ5, IC50: 79 nM (Binds to Vitronectin)
                  99.32%
MK-0429
αvβ1, IC50: 1.6 nM (inhibition of fibronectin-binding )
αvβ3, IC50: 2.8 nM (inhibition of vitronectin-binding)
αvβ5, IC50: 0.1 nM (inhibition of vitronectin-binding)
αvβ6, IC50: 0.7 nM (inhibition of LAP-binding)
αvβ8, IC50: 0.5 nM (inhibition of LAP-binding)
α5β1, IC50: 12.2 nM (inhibition of fibronectin-binding)
            99.84%
Firategrast              
α4β1
   
α4β7
  99.88%
Lifitegrast                      
αLβ2
99.58%
TR-14035              
α4β1, IC50: 87 nM
   
α4β7, IC50: 7 nM
  95.14%
BIO5192 hydrate            
α2β1, IC50: 1053 nM
α4β1, IC50: 1.8 nM
α9β1, IC50: 138 nM
 
α4β7, IC50: >500 nM
  ≥98.0%
THI0019              
α4β1, EC50: 1-2 μM
        ≥98.0%
Integrin modulator 1              
α4β1, IC50: 9.8 nM
        99.43%
HSDVHK-NH2  
αvβ3, IC50: 2.74 nM
                    99.63%
BIO5192            
α2β1, IC50: 1053 nM
α4β1, IC50: 1.8 nM
α9β1, IC50: 138 nM
 
α4β7, IC50: >500 nM
 
Echistatin TFA  
αvβ3
     
α5β1
     
αIIbβ3
    95.13%
BIO-1211              
α4β1, IC50: 4 nM
   
α4β7, IC50: 2 μM
  99.64%
Echistatin  
αvβ3
     
α5β1
     
αIIbβ3
   
EMD527040      
αvβ6, IC50: 6 nM
               
RO0270608              
α4β1
   
α4β7
 
BOP sodium              
α4β1
α9β1
     
R-BC154 acetate                
α9β1