Signaling Pathway

KSP

KSP

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Kinesin spindle protein (KSP), a member of the kinesin superfamily of microtubule-based motors, plays a critical role in mitosis as it mediates centrosome separation and bipolar spindle assembly and maintenance. Inhibition of KSP function leads to cell cycle arrest at mitosis with the formation of monoastral microtubule arrays, and ultimately, to cell death. Several KSP inhibitors are currently being studied in clinical trials and provide new opportunities for the development of novel anticancer therapeutics.

KSP Inhibitors & Modulators (8)

Product Name Catalog No. Brief Description
ARRY-520

HY-15187

ARRY-520 is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

ARRY-520 R enantiomer

HY-15187A

ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

Dimethylenastron

HY-19944

Dimethylenastron is an Eg5 inhibitor, which arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.

Ispinesib

HY-50759

Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.

K858

HY-19966

K858 selectively inhibits Eg5 ATPase activity with an IC50 of 1.3 μM.

Litronesib

HY-14846

Litronesib is a selective, allosteric inhibitor of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing.

Litronesib Racemate

HY-14846A

Litronesib Racemate is the racemate of litronesib.

SB-743921

HY-12069

SB-743921 is a second generation, highly potent and active KSP inhibitor with Ki of 0.1 nM; no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.