1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MEK
  4. MEK Inhibitors

MEK Inhibitors

MEK1

MEK2

MEK5

MEK

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

MEK Inhibitors & Antagonists
Product Name MEK1 MEK2 MEK5 MEK Purity
U0126
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
    98.06%
PD98059
MEK1, IC50: 2-7 μM
MEK2, IC50: 50 μM
    99.84%
Trametinib
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
    99.44%
PD0325901
MEK1, IC50: 0.33 nM
      99.95%
Trametinib (DMSO solvate)
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
    99.77%
Theaflavin 3,3'-digallate
MEK1
MEK2
    98.70%
MS432
MEK1, DC50: 31 nM (in HT29 cells)
MEK1, DC50: 31 nM (in SK-MEL-28 cells)
MEK2, DC50: 17 nM (in HT29 cells)
MEK2, DC50: 9.3 nM (in SK-MEL-28 cells)
   
Selumetinib
MEK1, IC50: 14 nM
   
MEK, IC50: 12 nM
99.87%
Cobimetinib
MEK1, IC50: 4.2 nM
      99.70%
Binimetinib      
MEK, IC50: 12 nM
99.55%
BIX02189    
MEK5, IC50: 1.5 nM
  99.99%
Ro 5126766      
MEK, IC50: 160 nM
97.92%
CI-1040
MEK1, IC50: 17 nM
      98.54%
Lidocaine hydrochloride      
MEK
99.95%
Lidocaine      
MEK
99.52%
Pimasertib
MEK1
MEK2
    99.95%
Isorhamnetin
MEK1
      99.95%
Refametinib
MEK1, IC50: 19 nM
MEK2, IC50: 47 nM
    99.82%
TAK-733      
MEK, IC50: 3.2 nM
99.81%
GDC-0623
MEK1, Ki: 0.13 nM (+ATP)
      99.15%
BIX02188    
MEK5, IC50: 4.3 nM
  99.49%
trans-Zeatin      
MEK
99.28%
SL327
MEK1, IC50: 180 nM
MEK2, IC50: 220 nM
    >98.0%
RO4987655
MEK1, IC50: 5.2 nM
MEK2, IC50: 5.2 nM
    99.17%
BI-847325  
MEK2, IC50: 4 nM
    99.14%
APS-2-79
MEK1
      99.31%
AZD8330
MEK1, IC50: 7 nM
MEK2, IC50: 7 nM
    98.75%
Cobimetinib hemifumarate
MEK1, IC50: 4.2 nM
      99.27%
MEK inhibitor      
MEK
98.68%
PD318088      
MEK
99.53%
Refametinib R enantiomer      
MEK, EC50: 2-15 nM
GW284543    
MEK5
  99.86%
CHMFL-EGFR-202
MEK1, IC50: 161 nM
     
Balamapimod      
MEK
MEK-IN-1      
MEK