1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MEK
  4. MEK Inhibitors

MEK Inhibitors

MEK1

MEK2

MEK5

MEK

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

MEK Inhibitors, Antagonists & Activators
Product Name MEK1 MEK2 MEK5 MEK Purity
Trametinib
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
    99.44%
U0126-EtOH
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
    ≥98.0%
PD98059
MEK1, IC50: 2-7 μM
MEK2, IC50: 50 μM
    99.94%
PD0325901
MEK1, Ki: 1 nM
MEK2, Ki: 1 nM
 
MEK, IC50: 0.33 nM
99.95%
Selumetinib
MEK1, IC50: 14 nM
   
MEK, IC50: 12 nM
99.87%
APS-2-79 hydrochloride
MEK1
     
Cobimetinib
MEK1, IC50: 4.2 nM
      99.71%
Trametinib (DMSO solvate)
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
    ≥98.0%
Binimetinib      
MEK, IC50: 12 nM
99.55%
Isorhamnetin
MEK1
      99.95%
BIX02189    
MEK5, IC50: 1.5 nM
  99.99%
CI-1040
MEK1, IC50: 17 nM
      ≥98.0%
Lidocaine      
MEK
≥98.0%
Ro 5126766      
MEK, IC50: 160 nM
98.27%
TAK-733      
MEK, IC50: 3.2 nM
99.81%
Refametinib
MEK1, IC50: 19 nM
MEK2, IC50: 47 nM
    99.82%
Lidocaine hydrochloride      
MEK
99.46%
Pimasertib
MEK1
MEK2
    99.70%
trans-Zeatin      
MEK
99.54%
GDC-0623
MEK1, Ki: 0.13 nM (+ATP)
      ≥95.0%
BI-847325  
MEK2, IC50: 4 nM
    99.14%
Cobimetinib hemifumarate
MEK1, IC50: 4.2 nM
      ≥99.0%
RO4987655
MEK1, IC50: 5.2 nM
MEK2, IC50: 5.2 nM
    99.17%
AZD8330
MEK1, IC50: 7 nM
MEK2, IC50: 7 nM
    99.14%
SL327
MEK1, IC50: 180 nM
MEK2, IC50: 220 nM
    ≥98.0%
APS-2-79
MEK1
      99.31%
BIX02188    
MEK5, IC50: 4.3 nM
  99.49%
MEK inhibitor      
MEK
98.55%
PD318088
MEK1
MEK2
    99.88%
GW284543    
MEK5
  99.86%
C16-PAF      
MEK
≥98.0%
Refametinib (R enantiomer)      
MEK, EC50: 2-15 nM
U0126
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
   
CHMFL-EGFR-202
MEK1, IC50: 161 nM
     
Balamapimod      
MEK
Hypothemycin
MEK1, Ki: 17 nM
MEK2, Ki: 38 nM
   
PD0325901-O-C2-dioxolane
MEK1
MEK2
   
MEK-IN-1      
MEK