Signaling Pathway

Monoamine transporter

Monoamine transporter

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Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT, DAT, NET) are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, norepinephrine). MATs are located just outside the synaptic cleft (peri-synaptically), transporting monoamine transmitter overflow from the synaptic cleft back to the cytoplasm of the pre-synaptic neuron. MAT regulation generally occurs throughphosphorylation and posttranslational modification. Due to their significance in neuronal signaling, MATs are commonly associated with drugs used to treat mental disorders as well as recreational drugs. Compounds targeting MATs range from medications such as the wide variety of tricyclic antidepressants, selective serotonin reuptake inhibitors to stimulantmedications and amphetamine.

Monoamine transporter Inhibitors & Modulators (11)

Product Name Catalog No. Brief Description
Corticosterone

HY-B1618

Corticosterone is a sensitive inhibitor of monoamine transport.

NBI-98782

HY-15793

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.

NBI-98854

HY-15793A

NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication.

Radafaxine hydrochloride

HY-17590

Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

Reserpine

HY-N0480

Reserpine (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).

Reserpine hydrochloride

HY-N0480A

Reserpine hydrochloride (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).

Tetrabenazine

HY-B0590

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.

Tetrabenazine (+)-

HY-B0590B

Tetrabenazine ((+)-) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2),  inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

Tetrabenazine D6

HY-B0590S

Tetrabenazine D6 is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.

Tetrabenazine Racemate

HY-B0590A

Tetrabenazine (Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).

Zinc Pyrithione

HY-B0572

Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.