Signaling Pathway

NRTIs

NRTIs

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Nucleoside reverse transcriptase inhibitors (NRTIs) are active inhibitors of reverse transcriptase found in retroviruses such as the human immunodeficiency virus (HIV). The different nucleoside reverse transcriptase inhibitors may be activated differently but they have the same mechanism of action. NRTIs are activated generally by phosphorylation to the triphosphate form by cellular enzymes. It then competes with cellular triphosphates, which are substrates for proviral DNA by viral reverse transcriptase. Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses.

NRTIs Inhibitors & Modulators (18)

Product Name Catalog No. Brief Description
Abacavir

HY-17423

Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

Abacavir sulfate

HY-17423A

Abacavir sulfate (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

Adefovir dipivoxil

HY-B0255

Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

Didanosine

HY-B0249

Didanosine(Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

Emtricitabine

HY-17427

Emtricitabine(BW1592) is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection.

GS-7340

HY-15232

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-7340 fumarate

HY-15232A

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-7340 hemifumarate

HY-15232B

GS-7340 (Tenofovir alafenamide) hemifumarate is an investigational oral prodrug of the HIV-1 nucleotide reverse transcriptase inhibitor Tenofovir (TFV).

Lamivudine

HY-B0250

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.

Stavudine

HY-B0116

Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Stavudine sodium

HY-B0116A

Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Tenofovir

HY-13910

Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

Tenofovir Disoproxil

HY-13782A

Tenofovir dsoproxil is an antiretroviral agent used to prevent and treat HIV/AIDS and to treat chronic hepatitis B.

Tenofovir Disoproxil Fumarate

HY-13782

Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

Tenofovir hydrate

HY-13910A

Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

Tenofovir maleate

HY-13910B

Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

Zalcitabine

HY-17392

Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); Zalcitabine is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase.

Zidovudine

HY-17413

Zidovudine (Azidothymidine, AZT) is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS infection.