1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K Inhibitors

PI3K Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

p120γ

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PI3K Inhibitors, Activators & Modulators
Product Name PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ Purity
3-Methyladenine    
PtdIns3Kγ, IC50: 60 μM (Cell Assay)
       
Vps34, IC50: 25 μM (Cell Assay)
      99.83%
LY294002
p110α, IC50: 0.5 μM
p110β, IC50: 0.97 μM
 
p110δ, IC50: 0.57 μM
              99.95%
Alpelisib
p110α, IC50: 5 nM
p110α-H1047R, IC50: 4 nM
p110α-E545K, IC50: 4 nM
p110β, IC50: 1200 nM
p110γ, IC50: 250 nM
p110δ, IC50: 290 nM
              99.95%
Wortmannin                
PI3K, IC50: 3 nM
    99.85%
Quercetin  
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 3 μM
PI3Kδ, IC50: 2.4 μM
              >98.0%
Gedatolisib
PI3Kα, IC50: 0.4 nM
PI3Kα-H1047R, IC50: 0.6 nM
PI3Kα-E545K, IC50: 0.6 nM
PI3Kβ, IC50: 6 nM
PI3Kγ, IC50: 5.4 nM
PI3Kδ, IC50: 6 nM
              99.68%
MSC2360844      
PI3Kδ, IC50: 145 nM
             
AMG 511
PI3Kα, Ki: 4 nM
PI3Kβ, Ki: 6 nM
PI3Kγ, Ki: 1 nM
PI3Kδ, Ki: 2 nM
              98.37%
Copanlisib
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
              98.91%
Buparlisib
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
      99.90%
740 Y-P                
PI3K
    98.32%
Idelalisib
p110α, IC50: 820 nM
p110β, IC50: 565 nM
p110γ, IC50: 89 nM
p110δ, IC50: 2.5 nM
     
hVps34, IC50: 978 nM
      99.98%
Pictilisib
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
              99.62%
IPI549
PI3Kα, IC50: 3.2 μM
PI3Kβ, IC50: 3.5 μM
PI3Kγ, IC50: 16 nM
                99.65%
Dactolisib
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
              99.68%
SAR405              
Vps34, IC50: 1.2 nM
Vps34, Kd: 1.5 nM
      99.52%
Duvelisib
p110α, IC50: 1602 nM
p110β, IC50: 85 nM
p110γ, IC50: 27.4 nM
p110δ, IC50: 2.5 nM
              99.91%
Fimepinostat
PI3Kα, IC50: 19 nM
PI3Kβ, IC50: 54 nM
PI3Kγ, IC50: 311 nM
PI3Kδ, IC50: 39 nM
              99.95%
GDC-0077
PI3Kα, IC50: 0.038 nM
                    98.94%
PI-103
p110α, IC50: 8 nM
p110β, IC50: 88 nM
p110γ, IC50: 150 nM
p110δ, IC50: 48 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
 
hsVPS34, IC50: 2.3 μM
      99.86%
Samotolisib
PI3Kα, IC50: 6.07 nM
PI3Kβ, IC50: 77.6 nM
PI3Kγ, IC50: 23.8 nM
PI3Kδ, IC50: 38 nM
              99.77%
Omipalisib
p110α, Ki: 0.019 nM
p110α-H1047R, Ki: 0.009 nM
p110α-E545K, Ki: 0.008 nM
p110α-E542K, Ki: 0.008 nM
p110β, Ki: 0.13 nM
p110γ, Ki: 0.06 nM
p110δ, Ki: 0.024 nM
              99.31%
PF-04691502
PI3Kα, Ki: 1.8 nM
PI3Kβ, Ki: 2.1 nM
PI3Kγ, Ki: 1.9 nM
PI3Kδ, Ki: 1.6 nM
              99.64%
YM-201636
p110α, IC50: 3.3 μM
                    98.22%
Taselisib
PI3Kα, Ki: 0.29 nM
PI3Kβ, Ki: 9.1 nM
PI3Kγ, Ki: 0.97 nM
PI3Kδ, Ki: 0.12 nM
              99.46%
ZSTK474
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 44 nM
PI3Kγ, IC50: 49 nM
PI3Kδ, IC50: 4.6 nM
              99.71%
GSK2636771  
p110β
                  99.86%
TG100-115    
PI3Kγ, IC50: 83 nM
PI3Kδ, IC50: 235 nM
              99.31%
Isorhamnetin                
PI3-K
    99.95%
Paxalisib
PI3Kα, Ki: 2 nM
PI3Kβ, Ki: 46 nM
PI3Kγ, Ki: 10 nM
PI3Kδ, Ki: 3 nM
              99.28%
Umbralisib      
PI3Kδ, IC50: 22.2 nM
              98.55%
Serabelisib
p110α, IC50: 15 nM
p110β, IC50: 4500 nM
p110γ, IC50: 1900 nM
p110δ, IC50: 13900 nM
              99.66%
AZD8186
PI3Kα, IC50: 35 nM
PI3Kβ, IC50: 4 nM
PI3Kγ, IC50: 675 nM
PI3Kδ, IC50: 12 nM
              99.97%
Apitolisib
PI3Kα, IC50: 5 nM
PI3Kβ, IC50: 27 nM
PI3Kγ, IC50: 14 nM
PI3Kδ, IC50: 7 nM
              98.26%
AZD 6482
PI3Kα, IC50: 136 nM
PI3Kβ, IC50: 0.69 nM
PI3Kγ, IC50: 47.8 nM
PI3Kδ, IC50: 13.6 nM
 
PI3K-C2β, IC50: 54.1 nM
 
hVps34, IC50: 3390 nM
      99.29%
TGX-221  
p110β, IC50: 8.5 nM
 
p110δ, IC50: 211 nM
              99.64%
AS-605240
PI3Kα, IC50: 60 nM
PI3Kβ, IC50: 270 nM
PI3Kγ, IC50: 8 nM
PI3Kδ, IC50: 300 nM
              >98.0%
PIK-93
p110α, IC50: 39 nM
p110β, IC50: 590 nM
p110γ, IC50: 16 nM
p110δ, IC50: 120 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
 
hsVPS34, IC50: 320 nM
      99.37%
Bimiralisib
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kβ, IC50: 661 nM
PI3Kγ, IC50: 708 nM
PI3Kδ, IC50: 451 nM
     
Vps34, IC50: 6486 nM
      98.90%
Vps34-PIK-III
PI(3)Kα, IC50: 3.96 μM
 
PI(3)Kγ, IC50: 3.04 μM
PI(3)Kδ, IC50: 1.2 μM
     
Vps34, IC50: 18 nM
      99.73%
1,3-Dicaffeoylquinic acid                
PI3K
    99.82%
Vps34-IN-1              
Vps34, IC50: 4 nM
      99.22%
HS-173
PI3Kα, IC50: 0.8 nM
                    99.04%
Pictilisib dimethanesulfonate
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
              99.31%
PI3K-IN-1                
PI3K
    99.93%
Leniolisib
PI3Kα, IC50: 280 nM
PI3Kβ, IC50: 480 nM
PI3Kγ, IC50: 2.57 μM
PI3Kδ, IC50: 11 nM
              99.25%
Voxtalisib
p110α, IC50: 39 nM
p110β, IC50: 113 nM
p110γ, IC50: 9 nM
p110δ, IC50: 43 nM
              99.46%
Dactolisib Tosylate
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
              99.89%
CH5132799
PI3Kα, IC50: 14 nM
PI3Kα-H1047R, IC50: 5.6 nM
PI3Kα-E545K, IC50: 6.7 nM
PI3Kα-E542K, IC50: 6.7 nM
PI3Kβ, IC50: 120 nM
PI3Kγ, IC50: 36 nM
PI3Kδ, IC50: 500 nM
 
PI3KC2β, IC50: 5.3 μM
          >98.0%
Acalisib
p110α, IC50: 5441 nM
p110β, IC50: 3377 nM
p110γ, IC50: 1389 nM
p110δ, IC50: 12.7 nM
     
hVps34, IC50: 12682 nM
      99.98%
IC-87114  
PI3Kβ, IC50: 75 μM
PI3Kγ, IC50: 29 μM
PI3Kδ, IC50: 0.5 μM
              98.97%
SAR-260301
PI3Kα, IC50: 1539 nM
PI3Kβ, IC50: 23 nM
PI3Kγ, IC50: 10000 nM
PI3Kδ, IC50: 468 nM
   
PI3KC2γ, IC50: 3812 nM
Vps34, IC50: 183 nM
      99.74%
AS-252424
PI3Kα, IC50: 935 nM
PI3Kβ, IC50: 20 μM
PI3Kγ, IC50: 30 nM
PI3Kδ, IC50: 20 μM
              99.31%
Nemiralisib
PI3Kα, pIC50: 5.3
PI3Kβ, pIC50: 5.8
PI3Kγ, pIC50: 5.2
PI3Kδ, pKi: 9.9
              99.50%
PIK-75 hydrochloride
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110γ, IC50: 76 nM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
      99.91%
CNX-1351
PI3Kα, IC50: 6.8 nM
PI3Kβ, IC50: 166 nM
PI3Kγ, IC50: 3020 nM
PI3Kδ, IC50: 240.3 nM
              99.88%
PI4KIIIbeta-IN-9
PI3Kα, IC50: 2 μM
 
PI3Kγ, IC50: 1046 nM
PI3Kδ, IC50: 152 nM
   
PI3KC2γ, IC50: 1 μM
        98.75%
BGT226 maleate
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 63 nM
PI3Kγ, IC50: 38 nM
                99.76%
Quercetin dihydrate  
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 2.4 μM
PI3Kδ, IC50: 3.0 μM
              >97.0%
PKI-402
PI3Kα, IC50: 2 nM
PI3Kα-H1047R, IC50: 3 nM
PI3Kα-E545K, IC50: 3 nM
PI3Kβ, IC50: 7 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 14 nM
              99.79%
PI-103 Hydrochloride
p110α, IC50: 2 nM
p110β, IC50: 3 nM
p110γ, IC50: 15 nM
p110δ, IC50: 3 nM
              98.06%
AZD-8835
PI3Kα, IC50: 6.2 nM
PI3Kα-E545K, IC50: 6 nM
PI3Kα-H1047R, IC50: 5.8 nM
PI3Kβ, IC50: 431 nM
PI3Kγ, IC50: 90 nM
PI3Kδ, IC50: 5.7 nM
              98.93%
GDC-0326
PI3Kα, Ki: 0.2 nM
PI3Kβ, Ki: 26.6 nM
PI3Kγ, Ki: 10.2 nM
PI3Kδ, Ki: 4 nM
              99.70%
VS-5584
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 68 nM
PI3Kγ, IC50: 25 nM
PI3Kδ, IC50: 42 nM
     
Vps34, IC50: 7470 nM
      98.01%
SF2523
PI3Kα, IC50: 34 nM
 
PI3Kγ, IC50: 158 nM
                97.32%
Sonolisib
p110α, IC50: 0.1 nM
   
p110δ, IC50: 2.9 nM
           
p120γ, IC50: 1 nM
>99.0%
GNE-477
PI3Kα, IC50: 4 nM
                    95.81%
Seletalisib      
PI3Kδ, IC50: 12 nM
              98.50%
GSK1059615
PI3Kα, IC50: 0.4 nM
PI3Kβ, IC50: 0.6 nM
PI3Kγ, IC50: 2 nM
PI3Kδ, IC50: 5 nM
              >99.0%
GNE-317                
PI3K
    99.26%
PI-3065
p110α, IC50: 910 nM
p110β, IC50: 600 nM
 
p110δ, IC50: 5 nM
              99.82%
Buparlisib Hydrochloride
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
      99.79%
AMG319
PI3Kα, IC50: 33 μM
PI3Kβ, IC50: 2.7 μM
PI3Kγ, IC50: 850 nM
PI3Kδ, IC50: 18 nM
              98.40%
Tenalisib    
PI3Kγ, IC50: 33 nM
PI3Kδ, IC50: 25 nM
              99.09%
Vps34-IN-2              
Vps34, IC50: 2 nM
      99.63%
IITZ-01    
PI3Kγ, IC50: 2.62 μM
                99.80%
CZC24832  
PI3Kβ, IC50: 1.1 μM
PI3Kγ, IC50: 27 nM
PI3Kδ, IC50: 8.194 μM
              99.46%
A66
p110α, IC50: 32 nM
p110α E545K, IC50: 30 nM
p110α H1047R, IC50: 43 nM
 
p110γ, IC50: 3480 nM
   
PI3K-C2β, IC50: 462 nM
          99.26%
PI3Kδ-IN-2      
PI3Kδ, IC50: 6.4 nM
              99.80%
α-Linolenic acid                
PI3K
    >98.0%
Esculetin                
PI3K
    >98.0%
PF-4989216
PI3Kα, Ki: 0.6 nM
                    99.43%
PIK-90
p110α, IC50: 11 nM
p110β, IC50: 350 nM
p110γ, IC50: 18 nM
p110δ, IC50: 58 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
 
hsVPS34, IC50: 830 nM
      99.70%
Pilaralisib
PI3Kα, IC50: 39 nM
PI3Kβ, IC50: 383 nM
PI3Kγ, IC50: 23 nM
PI3Kδ, IC50: 36 nM
     
Vps34, IC50: 6974 nM
      99.57%
Umbralisib hydrochloride      
PI3Kδ, IC50: 22.2 nM
              99.63%
PF-04979064
PI3Kα, Ki: 0.13 nM
 
PI3Kγ, Ki: 0.111 nM
PI3Kδ, Ki: 0.122 nM
              99.75%
Recilisib                
PI3K
    98.94%
Pilaralisib analogue
PI3K-alpha
                    96.75%
MTX-211                
PI3K
    >98.0%
CAY10505    
PI3Kγ, IC50: 30 nM (Neurons)
                99.79%
CGS 15943    
p110γ, IC50: 1.1 μM
p110δ, IC50: 8.47 μM
              99.63%
Sophocarpine                
PI3K
    >98.0%
Polygalasaponin F                
PI3K
    >99.0%
Arnicolide D                
PI3K
    >99.0%
Brevianamide F
PI3Kα, IC50: 4.8 μM
                    99.49%
PIK-294
p110α, IC50: 10 μM
p110β, IC50: 490 nM
p110γ, IC50: 160 nM
p110δ, IC50: 10 nM
              99.67%
Duvelisib R enantiomer                
PI3K
   
IPI-3063
p110α, IC50: 1170 nM
p110β, IC50: 1508 nM
p110γ, IC50: 2187 nM
p110δ, IC50: 2.5 nM
              98.80%
PI3K/mTOR Inhibitor-2
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 34 nM
PI3Kγ, IC50: 1 nM
PI3Kδ, IC50: 16 nM
              99.45%
BEBT-908
PI3Kα, IC50: 0.1 μM
                    >98.0%
ETP-46321
p110α, Ki: 2.3 nM
PI3Kα-H1047R, Ki: 2.33 nM
PI3Kα-E545K, Ki: 1.77 nM
PI3Kα-E542K, Ki: 1.89 nM
p110β, Ki: 170 nM
p110γ, Ki: 179 nM
p110δ, Ki: 14.2 nM
              99.65%
GNE-493
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 12 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 16 nM
              95.12%
PQR-530                
PI3K
   
NSC781406
PI3Kα, IC50: 2 nM
PI3Kβ, IC50: 9.4 nM
PI3Kγ, IC50: 2.7 nM
PI3Kδ, IC50: 14 nM
              99.91%
AZD3458
PI3Kα, pIC50: 5.1
PI3Kβ, pIC50: 4.5
PI3Kγ, pIC50: 9.1
PI3Kδ, pIC50: 6.5
PI3KC2α, pIC50: 5
PI3KC2β, pIC50: 7.5
PI3KC2γ, pIC50: 5.5
   
PI3KC3, pIC50: 5.1
  99.82%
Copanlisib dihydrochloride
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
              99.55%
KP-23172                
PI3-K
    99.44%
Sophocarpine monohydrate                
PI3K
    >99.0%
AS-604850
PI3Kα, IC50: 4.5 μM
 
PI3Kγ, IC50: 0.25 μM
PI3Kγ, Ki: 0.18 μM
                99.91%
Hederacolchiside A1                
PI3K
    >99.0%
PI-828
p110α, IC50: 173 nM
                    >98.0%
Glaucocalyxin A                
PI3K
   
NVP-QAV-572                
PI3K, IC50: 10 nM
    98.05%
CAL-130 Hydrochloride
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM
              99.88%
MSC2360844 hemifumarate      
PI3Kδ, IC50: 145 nM
             
TG 100713
PI3Kα, IC50: 165 nM
PI3Kβ, IC50: 215 nM
PI3Kγ, IC50: 50 nM
PI3Kδ, IC50: 24 nM
              98.63%
WYE-687 dihydrochloride
PI3K alpha, IC50: 81 nM
 
PI3K gamma, IC50: 3.11 μM
                >98.0%
Umbralisib R-enantiomer      
PI3Kδ
              99.52%
ON 146040
PI3Kα, IC50: 14 nM
PI3Kβ, IC50: 3 μM
PI3Kγ, IC50: 1 μM
PI3Kδ, IC50: 20 nM
             
CAL-130
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM