1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K Inhibitors

PI3K Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

p120γ

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PI3K Inhibitors, Activators & Modulators
Product Name PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ Purity
3-Methyladenine    
PtdIns3Kγ, IC50: 60 μM (Cell Assay)
       
Vps34, IC50: 25 μM (Cell Assay)
      99.83%
LY294002
p110α, IC50: 0.5 μM
p110β, IC50: 0.97 μM
 
p110δ, IC50: 0.57 μM
              99.95%
Alpelisib
p110α, IC50: 5 nM
p110α-H1047R, IC50: 4 nM
p110α-E545K, IC50: 4 nM
p110β, IC50: 1200 nM
p110γ, IC50: 250 nM
p110δ, IC50: 290 nM
              99.95%
Wortmannin                
PI3K, IC50: 3 nM
    99.85%
Quercetin  
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 3 μM
PI3Kδ, IC50: 2.4 μM
              >98.0%
Gedatolisib
PI3Kα, IC50: 0.4 nM
PI3Kα-H1047R, IC50: 0.6 nM
PI3Kα-E545K, IC50: 0.6 nM
PI3Kβ, IC50: 6 nM
PI3Kγ, IC50: 5.4 nM
PI3Kδ, IC50: 6 nM
              99.68%
PQR530
PI3Kα, Kd: 0.84 nM
PI3Kβ, Kd: 6.1 nM
PI3Kγ, Kd: 10 nM
PI3Kδ, Kd: 11 nM
 
PI3KC2β, Kd: 100 nM
          99.93%
740 Y-P                
PI3K
    99.67%
Idelalisib
p110α, IC50: 820 nM
p110β, IC50: 565 nM
p110γ, IC50: 89 nM
p110δ, IC50: 2.5 nM
     
hVps34, IC50: 978 nM
      99.98%
Buparlisib
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
      99.90%
Copanlisib
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
              98.91%
Pictilisib
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
              99.62%
IPI549
PI3Kα, IC50: 3.2 μM
PI3Kβ, IC50: 3.5 μM
PI3Kγ, IC50: 16 nM
                99.65%
Dactolisib
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
              99.68%
Duvelisib
p110α, IC50: 1602 nM
p110β, IC50: 85 nM
p110γ, IC50: 27.4 nM
p110δ, IC50: 2.5 nM
              99.91%
SAR405              
Vps34, IC50: 1.2 nM
Vps34, Kd: 1.5 nM
      99.52%
Fimepinostat
PI3Kα, IC50: 19 nM
PI3Kβ, IC50: 54 nM
PI3Kγ, IC50: 311 nM
PI3Kδ, IC50: 39 nM
              99.95%
GDC-0077
PI3Kα, IC50: 0.038 nM
                    98.94%
PI-103
p110α, IC50: 8 nM
p110β, IC50: 88 nM
p110γ, IC50: 150 nM
p110δ, IC50: 48 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
 
hsVPS34, IC50: 2.3 μM
      99.86%
YM-201636
p110α, IC50: 3.3 μM
                    98.22%
PF-04691502
PI3Kα, Ki: 1.8 nM
PI3Kβ, Ki: 2.1 nM
PI3Kγ, Ki: 1.9 nM
PI3Kδ, Ki: 1.6 nM
              99.64%
Taselisib
PI3Kα, Ki: 0.29 nM
PI3Kβ, Ki: 9.1 nM
PI3Kγ, Ki: 0.97 nM
PI3Kδ, Ki: 0.12 nM
              99.46%
Samotolisib
PI3Kα, IC50: 6.07 nM
PI3Kβ, IC50: 77.6 nM
PI3Kγ, IC50: 23.8 nM
PI3Kδ, IC50: 38 nM
              99.77%
Parsaclisib      
PI3Kδ, IC50: 1 nM
              99.31%
Omipalisib
p110α, Ki: 0.019 nM
p110α-H1047R, Ki: 0.009 nM
p110α-E545K, Ki: 0.008 nM
p110α-E542K, Ki: 0.008 nM
p110β, Ki: 0.13 nM
p110γ, Ki: 0.06 nM
p110δ, Ki: 0.024 nM
              99.31%
ZSTK474
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 44 nM
PI3Kγ, IC50: 49 nM
PI3Kδ, IC50: 4.6 nM
              99.71%
Isorhamnetin                
PI3-K
    99.95%
GSK2636771  
p110β
                  99.86%
Serabelisib
p110α, IC50: 15 nM
p110β, IC50: 4500 nM
p110γ, IC50: 1900 nM
p110δ, IC50: 13900 nM
              99.66%
AZD8186
PI3Kα, IC50: 35 nM
PI3Kβ, IC50: 4 nM
PI3Kγ, IC50: 675 nM
PI3Kδ, IC50: 12 nM
              99.97%
AS-605240
PI3Kα, IC50: 60 nM
PI3Kβ, IC50: 270 nM
PI3Kγ, IC50: 8 nM
PI3Kγ, Ki: 7.8 nM
PI3Kδ, IC50: 300 nM
              >98.0%
TG100-115    
PI3Kγ, IC50: 83 nM
PI3Kδ, IC50: 235 nM
              99.31%
Apitolisib
PI3Kα, IC50: 5 nM
PI3Kβ, IC50: 27 nM
PI3Kγ, IC50: 14 nM
PI3Kδ, IC50: 7 nM
              98.26%
PIK-93
p110α, IC50: 39 nM
p110β, IC50: 590 nM
p110γ, IC50: 16 nM
p110δ, IC50: 120 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
 
hsVPS34, IC50: 320 nM
      99.37%
Umbralisib      
PI3Kδ, IC50: 22.2 nM
              98.55%
AZD 6482
PI3Kα, IC50: 136 nM
PI3Kβ, IC50: 0.69 nM
PI3Kγ, IC50: 47.8 nM
PI3Kδ, IC50: 13.6 nM
 
PI3K-C2β, IC50: 54.1 nM
 
hVps34, IC50: 3390 nM
      99.29%
Dactolisib Tosylate
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
              99.88%
PI3K-IN-1                
PI3K
    99.93%
TGX-221  
p110β, IC50: 8.5 nM
 
p110δ, IC50: 211 nM
              99.64%
Vps34-PIK-III
PI(3)Kα, IC50: 3.96 μM
 
PI(3)Kγ, IC50: 3.04 μM
PI(3)Kδ, IC50: 1.2 μM
     
Vps34, IC50: 18 nM
      99.73%
Vps34-IN-1              
Vps34, IC50: 4 nM
      99.22%
Bimiralisib
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kβ, IC50: 661 nM
PI3Kγ, IC50: 708 nM
PI3Kδ, IC50: 451 nM
     
Vps34, IC50: 6486 nM
      98.74%
PIK-75 hydrochloride
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110γ, IC50: 76 nM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
      99.91%
CH5132799
PI3Kα, IC50: 14 nM
PI3Kα-H1047R, IC50: 5.6 nM
PI3Kα-E545K, IC50: 6.7 nM
PI3Kα-E542K, IC50: 6.7 nM
PI3Kβ, IC50: 120 nM
PI3Kγ, IC50: 36 nM
PI3Kδ, IC50: 500 nM
 
PI3KC2β, IC50: 5.3 μM
          98.81%
Leniolisib
PI3Kα, IC50: 280 nM
PI3Kβ, IC50: 480 nM
PI3Kγ, IC50: 2.57 μM
PI3Kδ, IC50: 11 nM
              99.25%
HS-173
PI3Kα, IC50: 0.8 nM
                    99.04%
Pictilisib dimethanesulfonate
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
              99.31%
Voxtalisib
p110α, IC50: 39 nM
p110β, IC50: 113 nM
p110γ, IC50: 9 nM
p110δ, IC50: 43 nM
              99.46%
Sonolisib
p110α, IC50: 0.1 nM
   
p110δ, IC50: 2.9 nM
           
p120γ, IC50: 1 nM
99.49%
PI4KIIIbeta-IN-9
PI3Kα, IC50: 2 μM
 
PI3Kγ, IC50: 1046 nM
PI3Kδ, IC50: 152 nM
   
PI3KC2γ, IC50: 1 μM
        98.75%
BGT226 maleate
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 63 nM
PI3Kγ, IC50: 38 nM
                99.76%
VS-5584
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 68 nM
PI3Kγ, IC50: 25 nM
PI3Kδ, IC50: 42 nM
     
Vps34, IC50: 7470 nM
      98.01%
IC-87114  
PI3Kβ, IC50: 75 μM
PI3Kγ, IC50: 29 μM
PI3Kδ, IC50: 0.5 μM
              98.97%
α-Linolenic acid                
PI3K
    >99.0%
CNX-1351
PI3Kα, IC50: 6.8 nM
PI3Kβ, IC50: 166 nM
PI3Kγ, IC50: 3020 nM
PI3Kδ, IC50: 240.3 nM
              99.88%
AS-252424
PI3Kα, IC50: 935 nM
PI3Kβ, IC50: 20 μM
PI3Kγ, IC50: 30 nM
PI3Kδ, IC50: 20 μM
              99.31%
GSK1059615
PI3Kα, IC50: 0.4 nM
PI3Kβ, IC50: 0.6 nM
PI3Kγ, IC50: 2 nM
PI3Kδ, IC50: 5 nM
              >99.0%
SF2523
PI3Kα, IC50: 34 nM
 
PI3Kγ, IC50: 158 nM
                97.32%
Quercetin dihydrate  
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 2.4 μM
PI3Kδ, IC50: 3.0 μM
              >97.0%
1,3-Dicaffeoylquinic acid                
PI3K
    98.85%
PKI-402
PI3Kα, IC50: 2 nM
PI3Kα-H1047R, IC50: 3 nM
PI3Kα-E545K, IC50: 3 nM
PI3Kβ, IC50: 7 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 14 nM
              99.79%
Recilisib                
PI3K
    98.94%
GDC-0326
PI3Kα, Ki: 0.2 nM
PI3Kβ, Ki: 26.6 nM
PI3Kγ, Ki: 10.2 nM
PI3Kδ, Ki: 4 nM
              99.70%
Acalisib
p110α, IC50: 5441 nM
p110β, IC50: 3377 nM
p110γ, IC50: 1389 nM
p110δ, IC50: 12.7 nM
     
hVps34, IC50: 12682 nM
      99.98%
PI-103 Hydrochloride
p110α, IC50: 2 nM
p110β, IC50: 3 nM
p110γ, IC50: 15 nM
p110δ, IC50: 3 nM
              98.06%
SAR-260301
PI3Kα, IC50: 1539 nM
PI3Kβ, IC50: 23 nM
PI3Kγ, IC50: 10000 nM
PI3Kδ, IC50: 468 nM
   
PI3KC2γ, IC50: 3812 nM
Vps34, IC50: 183 nM
      99.74%
AMG319
PI3Kα, IC50: 33 μM
PI3Kβ, IC50: 2.7 μM
PI3Kγ, IC50: 850 nM
PI3Kδ, IC50: 18 nM
              98.40%
AZD-8835
PI3Kα, IC50: 6.2 nM
PI3Kα-E545K, IC50: 6 nM
PI3Kα-H1047R, IC50: 5.8 nM
PI3Kβ, IC50: 431 nM
PI3Kγ, IC50: 90 nM
PI3Kδ, IC50: 5.7 nM
              98.93%
Nemiralisib
PI3Kα, pIC50: 5.3
PI3Kβ, pIC50: 5.8
PI3Kγ, pIC50: 5.2
PI3Kδ, pKi: 9.9
              99.50%
Seletalisib      
PI3Kδ, IC50: 12 nM
              98.50%
GNE-317                
PI3K
    99.31%
Tenalisib    
PI3Kγ, IC50: 33 nM
PI3Kδ, IC50: 25 nM
              99.09%
GNE-477
PI3Kα, IC50: 4 nM
                    95.81%
A66
p110α, IC50: 32 nM
p110α E545K, IC50: 30 nM
p110α H1047R, IC50: 43 nM
 
p110γ, IC50: 3480 nM
   
PI3K-C2β, IC50: 462 nM
          99.26%
Pilaralisib
PI3Kα, IC50: 39 nM
PI3Kβ, IC50: 383 nM
PI3Kγ, IC50: 23 nM
PI3Kδ, IC50: 36 nM
     
Vps34, IC50: 6974 nM
      99.57%
IITZ-01    
PI3Kγ, IC50: 2.62 μM
                99.80%
Copanlisib dihydrochloride
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
              99.55%
CZC24832  
PI3Kβ, IC50: 1.1 μM
PI3Kγ, IC50: 27 nM
PI3Kδ, IC50: 8.194 μM
              99.46%
Esculetin                
PI3K
    >98.0%
AMG 511
PI3Kα, Ki: 4 nM
PI3Kβ, Ki: 6 nM
PI3Kγ, Ki: 1 nM
PI3Kδ, Ki: 2 nM
              98.37%
PI-3065
p110α, IC50: 910 nM
p110β, IC50: 600 nM
 
p110δ, IC50: 5 nM
              99.82%
Buparlisib Hydrochloride
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
      99.79%
Vps34-IN-2              
Vps34, IC50: 2 nM
      99.63%
Linperlisib      
PI3Kδ, IC50: 6.4 nM
              99.80%
PF-4989216
PI3Kα, Ki: 0.6 nM
                    99.43%
CGS 15943    
p110γ, IC50: 1.1 μM
p110δ, IC50: 8.47 μM
              99.63%
Sophocarpine                
PI3K
    >98.0%
PIK-90
p110α, IC50: 11 nM
p110β, IC50: 350 nM
p110γ, IC50: 18 nM
p110δ, IC50: 58 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
 
hsVPS34, IC50: 830 nM
      99.70%
Umbralisib hydrochloride      
PI3Kδ, IC50: 22.2 nM
              99.63%
KP372-1                
PI3-K
    99.52%
MTX-211                
PI3K
    >98.0%
AZD3458
PI3Kα, pIC50: 5.1
PI3Kβ, pIC50: 4.5
PI3Kγ, pIC50: 9.1
PI3Kδ, pIC50: 6.5
PI3KC2α, pIC50: 5
PI3KC2β, pIC50: 7.5
PI3KC2γ, pIC50: 5.5
   
PI3KC3, pIC50: 5.1
  99.82%
PI3K/mTOR Inhibitor-2
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 34 nM
PI3Kγ, IC50: 1 nM
PI3Kδ, IC50: 16 nM
              99.45%
PF-04979064
PI3Kα, Ki: 0.13 nM
 
PI3Kγ, Ki: 0.111 nM
PI3Kδ, Ki: 0.122 nM
              99.75%
Polygalasaponin F                
PI3K
    >99.0%
Arnicolide D                
PI3K
    >99.0%
Brevianamide F
PI3Kα, IC50: 4.8 μM
                    99.49%
Duvelisib (R enantiomer)                
PI3K
   
NSC781406
PI3Kα, IC50: 2 nM
PI3Kβ, IC50: 9.4 nM
PI3Kγ, IC50: 2.7 nM
PI3Kδ, IC50: 14 nM
              99.91%
Pilaralisib analogue
PI3K-alpha
                    99.67%
MSC2360844
PI3Kα, IC50: 18500 nM
PI3Kβ, IC50: 2850 nM
 
PI3Kδ, IC50: 145 nM
              99.96%
CAY10505    
PI3Kγ, IC50: 30 nM (Neurons)
                99.79%
TG 100713
PI3Kα, IC50: 165 nM
PI3Kβ, IC50: 215 nM
PI3Kγ, IC50: 50 nM
PI3Kδ, IC50: 24 nM
              98.63%
BEBT-908
PI3Kα, IC50: 0.1 μM
                    >98.0%
Glaucocalyxin A                
PI3K
    99.38%
ETP-46321
p110α, Ki: 2.3 nM
PI3Kα-H1047R, Ki: 2.33 nM
PI3Kα-E545K, Ki: 1.77 nM
PI3Kα-E542K, Ki: 1.89 nM
p110β, Ki: 170 nM
p110γ, Ki: 179 nM
p110δ, Ki: 14.2 nM
              99.65%
PIK-294
p110α, IC50: 10 μM
p110β, IC50: 490 nM
p110γ, IC50: 160 nM
p110δ, IC50: 10 nM
              99.67%
IPI-3063
p110α, IC50: 1170 nM
p110β, IC50: 1508 nM
p110γ, IC50: 2187 nM
p110δ, IC50: 2.5 nM
              98.80%
Sophocarpine monohydrate                
PI3K
    >99.0%
AS-604850
PI3Kα, IC50: 4.5 μM
 
PI3Kγ, IC50: 0.25 μM
PI3Kγ, Ki: 0.18 μM
                99.91%
Hederacolchiside A1                
PI3K
    99.69%
PI-828
p110α, IC50: 173 nM
                    >98.0%
NVP-QAV-572                
PI3K, IC50: 10 nM
    98.05%
GNE-493
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 12 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 16 nM
              95.12%
CAL-130 Hydrochloride
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM
              99.88%
Zandelisib      
PI3Kδ, IC50: 3.5 nM
              98.79%
IHMT-PI3Kδ-372      
PI3Kδ, IC50: 14 nM
             
Parsaclisib hydrochloride      
PI3Kδ, IC50: 1 nM
              98.74%
PI3Kδ-IN-8
PI3Kα, IC50: 377.2 nM
PI3Kβ, IC50: 241.6 nM
PI3Kγ, IC50: 17.9 nM
PI3Kδ, IC50: 3.3 nM
             
SRX3207
PI3Kα, IC50: 861 nM
 
PI3Kγ, IC50: 11100 nM
PI3Kδ, IC50: 1280 nM
             
MSC2360844 hemifumarate      
PI3Kδ, IC50: 145 nM
              99.95%
WYE-687 dihydrochloride
PI3K alpha, IC50: 81 nM
 
PI3K gamma, IC50: 3.11 μM
                >98.0%
Umbralisib R-enantiomer      
PI3Kδ
              99.52%
ON 146040
PI3Kα, IC50: 14 nM
PI3Kβ, IC50: 3 μM
PI3Kγ, IC50: 1 μM
PI3Kδ, IC50: 20 nM
             
CAL-130
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM