1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKC Inhibitors

PKC Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PKC Inhibitors, Antagonists, Activators & Modulators
Product Name PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ Purity
Phorbol 12-myristate 13-acetate
PKC, EC50: 11.7 nM
                  99.66%
Staurosporine
PKC, IC50: 6 nM
                  99.98%
Midostaurin  
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
    99.89%
Go 6983  
PKCα, IC50: 7 nM
PKCβ, IC50: 7 nM
PKCγ, IC50: 6 nM
PKCδ, IC50: 10 nM
   
PKCζ, IC50: 60 nM
 
PKCμ, IC50: 20000 nM
98.01%
ζ-Stat              
aPKC-ζ, IC50: 5 μM
    >95.0%
CRT0066854              
PKCζ, IC50: 639 nM
    >99.0%
Fasudil Hydrochloride
PKC, IC50: 12.30 μM
                  99.91%
Mitoxantrone
PKC, IC50: 8.5 μM
                  >98.0%
Bisindolylmaleimide I
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
            98.14%
Sotrastaurin  
PKCα, Ki: 0.95 nM
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
  99.83%
Enzastaurin  
PKCα, IC50: 39 nM
PKCβ, IC50: 6 nM
PKCγ, IC50: 83 nM
 
PKCε, IC50: 110 nM
        99.92%
Rottlerin  
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
    96.84%
Chelerythrine chloride
PKC, IC50: 660 nM
                  98.56%
Ro 31-8220 mesylate
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
        99.28%
Ingenol Mebutate  
PKC-α, Ki: 0.3 nM
PKC-β, Ki: 0.105 nM
PKC-γ, Ki: 0.162 nM
PKC-δ, Ki: 0.376 nM
PKC-ε, Ki: 0.171 nM
        99.07%
Afuresertib    
PKC-βI, IC50: 430 nM
     
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
  99.23%
LXS196  
PKCα, IC50: 1.9 nM
           
PKCθ, IC50: 0.4 nM
  99.68%
Ruboxistaurin hydrochloride  
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
      99.84%
CGP60474
PKC
                  98.70%
Mitoxantrone dihydrochloride
PKC, IC50: 8.5 μM
                  98.01%
Verbascoside
PKC, IC50: 25 μM
                  99.61%
D-erythro-Sphingosine
PKC
                  >98.0%
TPPB
PKC, Ki: 11.9 nM
                  99.81%
DCP-LA          
PKCε
        >98.0%
Afuresertib hydrochloride    
PKC-βI, IC50: 430 nM
     
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
  98.02%
Daphnetin
PKC, IC50: 25.01 μM
                  99.55%
HA-100
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
                  99.77%
Valrubicin
TPA-activated PKC, IC50: 0.85 μM
PDBu-activated PKC, IC50: 1.25 μM
                  99.95%
CMPD101  
PKCα, IC50: 8.1 μM
                98.68%
Delcasertib        
δPKC
          95.38%
VTX-27  
PKCα, Ki: 356 nM
   
PKCδ, Ki: 16 nM
     
PKCθ, Ki: 0.08 nM
  99.64%
Ingenol
PKC, Ki: 30 μM
                  98.17%
Bisindolylmaleimide X hydrochloride
PKC
                  98.53%
BJE6-106  
PKCα, IC50: 50 μM
   
PKCδ, IC50: 0.05 μM
          98.17%
KT5823
PKC, Ki: 4 μM
                  >99.0%
PKC-theta inhibitor                
PKCθ, IC50: 12 nM
  99.91%
Delcasertib hydrochloride        
δPKC
          98.11%
PKCβ inhibitor 1  
PKCα, IC50: 331 nM
human PKCβ1, IC50: 21 nM
human PKCβ2, IC50: 5 nM
              98.21%
R 59-022
PKC
                  >99.0%
SB-218078
PKC, IC50: 1000 nM
                  >98.0%
DCPLA-ME          
PKCε
        >98.0%
ζ-Stat trisodium              
aPKC-ζ, IC50: 5 μM
   
TAS-301
PKC
                  99.50%
Fasudil
PKC, IC50: 12.3 μM
                 
Chelerythrine
PKC, IC50: 0.7 μM
                 
N-Desmethyltamoxifen
PKC
                 
PKC β pseudosubstrate    
PKC-β
             
[Ala113]MBP(104-118)
PKC, IC50: 28-62 μM
                 
A-3 hydrochloride
PKC, Ki: 47 μM
                  99.67%
Bisindolylmaleimide IV
PKC, IC50: 0.1-0.55 μM
                 
Ro 32-0432 hydrochloride  
PKCα, IC50: 9.3 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
PKCγ, IC50: 36.5 nM
 
PKCε, IC50: 108.3 nM
       
[Ala107]MBP(104-118)
PKC, IC50: 46-145 μM
                 
TCS 21311  
PKCα, IC50: 13 nM
           
PKCθ, IC50: 68 nM
  >98.0%
PKC β pseudosubstrate TFA    
PKCβ
             
[Ala113]MBP(104-118) TFA
PKC, IC50: 28-62 μM
                 
Bisindolylmaleimide VIII acetate
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
 
PKC-ε, IC50: 175 nM
       
[Ala107]MBP(104-118) TFA
PKC, IC50: 46-145 μM