1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKC Inhibitors

PKC Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PKC Inhibitors, Antagonists & Activators
Product Name PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ Purity
Phorbol 12-myristate 13-acetate
PKC, EC50: 11.7 nM
                99.66%
Staurosporine
PKC, IC50: 6 nM
                99.98%
Midostaurin  
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
  99.89%
ζ-Stat trisodium              
aPKC-ζ, IC50: 5 μM
 
PKCβ inhibitor 1  
PKCα, IC50: 331 nM
human PKCβ1, IC50: 21 nM
human PKCβ2, IC50: 5 nM
            98.21%
Fasudil Hydrochloride
PKC, IC50: 12.30 μM
                99.91%
Mitoxantrone
PKC, IC50: 8.5 μM
                >98.0%
Bisindolylmaleimide I
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
          98.14%
Sotrastaurin  
PKCα, Ki: 0.95 nM
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
99.83%
Rottlerin  
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
  96.84%
Enzastaurin  
PKCα, IC50: 39 nM
PKCβ, IC50: 6 nM
PKCγ, IC50: 83 nM
 
PKCε, IC50: 110 nM
      99.90%
Chelerythrine chloride
PKC, IC50: 660 nM
                98.56%
LXS196  
PKCα, IC50: 1.9 nM
           
PKCθ, IC50: 0.4 nM
99.12%
Ro 31-8220 mesylate
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
      99.28%
Afuresertib    
PKC-βI, IC50: 430 nM
     
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
99.23%
Ruboxistaurin hydrochloride  
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
    99.84%
TPPB
PKC, Ki: 11.9 nM
                99.81%
Mitoxantrone dihydrochloride
PKC, IC50: 8.5 μM
                98.01%
CGP60474
PKC
                99.88%
HA-100
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
                99.76%
D-erythro-Sphingosine
PKC
                >98.0%
Valrubicin
TPA-activated PKC, IC50: 0.85 μM
PDBu-activated PKC, IC50: 1.25 μM
                99.95%
DCP-LA          
PKCε
      >98.0%
Afuresertib hydrochloride    
PKC-βI, IC50: 430 nM
     
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
98.02%
Daphnetin
PKC, IC50: 25.01 μM
                99.55%
Verbascoside
PKC, IC50: 25 μM
                99.61%
Ingenol
PKC, Ki: 30 μM
                >99.0%
Delcasertib        
δPKC
        95.38%
VTX-27  
PKCα, Ki: 356 nM
   
PKCδ, Ki: 16 nM
     
PKCθ, Ki: 0.08 nM
99.68%
CMPD101  
PKCα, IC50: 8.1 μM
              >98.0%
Bisindolylmaleimide X hydrochloride
PKC
                98.53%
PKC-theta inhibitor                
PKCθ, IC50: 12 nM
99.91%
KT5823
PKC, Ki: 4 μM
                >99.0%
BJE6-106  
PKCα, IC50: 50 μM
   
PKCδ, IC50: 0.05 μM
        98.17%
DCPLA-ME          
PKCε
      >98.0%
R 59-022
PKC
                >99.0%
TAS-301
PKC
                99.50%
Fasudil
PKC, IC50: 12.3 μM
               
ζ-Stat              
aPKC-ζ, IC50: 5 μM
 
Chelerythrine
PKC, IC50: 0.7 μM
               
Delcasertib hydrochloride        
δPKC
       
N-Desmethyltamoxifen
PKC
               
PKC β pseudosubstrate    
PKC-β
           
[Ala113]MBP(104-118)
PKC, IC50: 28-62 μM
               
A-3 hydrochloride
PKC, Ki: 47 μM
               
SB-218078
PKC, IC50: 1000 nM
                >98.0%
Bisindolylmaleimide IV
PKC, IC50: 0.1-0.55 μM
               
Ro 32-0432 hydrochloride  
PKCα, IC50: 9.3 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
PKCγ, IC50: 36.5 nM
 
PKCε, IC50: 108.3 nM
     
[Ala107]MBP(104-118)
PKC, IC50: 46-145 μM
               
TCS 21311  
PKCα, IC50: 13 nM
           
PKCθ, IC50: 68 nM
>98.0%
PKC β pseudosubstrate TFA    
PKCβ
           
[Ala113]MBP(104-118) TFA
PKC, IC50: 28-62 μM
               
Bisindolylmaleimide VIII acetate
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
 
PKC-ε, IC50: 175 nM
     
[Ala107]MBP(104-118) TFA
PKC, IC50: 46-145 μM