Prolyl Endopeptidase (PREP)

prolyl oligopeptidase; POP

Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.

Prolyl Endopeptidase (PREP) Inhibitors (16)

Prolyl Endopeptidase (PREP) Related Products (17):

Cat. No.	Product Name	Effect	Purity

HY-N0109

Salidroside	Inhibitor	99.79%
Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-W404002

BR102910	Inhibitor	99.80%
BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC₅₀ of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC₅₀ of 49.00 μM. BR102910 can be used for the researchof type 2

HY-113951

Prolyl Endopeptidase Inhibitor 1	Inhibitor
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a K_i value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect.

HY-N2481

Oroxylin A-7-O-glucuronide	Inhibitor	99.26%
Oroxylin A-7-O-glucuronide (Oroxyloside; Oroxylin A-7-O-β-D-glucuronide) is a flavonoid glucuronide isolated from the dried root of Scutellaria baicalensis, with prolyl oligopeptidase (POP) inhibitory activity.

HY-15114

S 17092	Inhibitor	98.42%
S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC₅₀ of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging.

HY-107758

Y-29794 oxalate	Inhibitor
Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM).

HY-N2454

β-Elemonic acid	Inhibitor	99.90%
β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.

HY-100475

KYP-2047	Inhibitor
KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an K_i value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation.

HY-143475

POP-IN-2	Inhibitor
POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a K_i of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer.

HY-148332

Z-Thioprolyl-Thiazolidine	Inhibitor
Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor with an K_i value of 0.36 nM for bovine brain prolyl endopeptidase

HY-137220

Z-Gly-Pro-pNA
Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity.

HY-139648

PREP inhibitor-1	Inhibitor
PREP inhibitor-1 is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC₅₀ < 1 nM).

HY-N6902

Linderene acetate	Inhibitor	99.31%
Linderene acetate, isolated from the root of Lindera strychnifolia, is a prolyl endopeptidase inhibitor.

HY-148331

Z-Thioprolyl-Thioproline	Inhibitor
Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC₅₀=16 µM; K_i=37 µM). Z-Thioprolyl-Thioproline is used in the study of neurological disorders such as memory disorders and cognitive disorders.

HY-143474

Y-29794	Inhibitor
Y-29794 (Compound 2) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a K_i of 0.95 nM. Y-29794 can be used for studying neurodegenerative diseases and cancer.

HY-15112

JTP-4819	Inhibitor
JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC₅₀s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096).

HY-134454A

Z-Pro-prolinal	Inhibitor
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC₅₀ of 0.4 nM for porcine PREP.

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