1. Signaling Pathways
  2. Immunology/Inflammation
    Metabolic Enzyme/Protease
    NF-κB
  3. Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Reactive Oxygen Species Related Products (155):

Cat. No. Product Name Effect Purity
  • HY-D0940
    H2DCFDA 99.82%
    H2DCFDA is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS).
  • HY-B0215
    Acetylcysteine Inhibitor >98.0%
    Acetylcysteine is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor.
  • HY-100116A
    Mitoquinone mesylate >98.0%
    Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage.
  • HY-13653
    (-)-Epigallocatechin Gallate 99.91%
    (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase.
  • HY-18950
    GSK2795039 Inhibitor 99.44%
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.
  • HY-16992A
    W-54011 Inhibitor >98.0%
    W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.
  • HY-101193
    Zinc Protoporphyrin >98.0%
    Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration.
  • HY-128784
    PK11007 Activator 99.60%
    PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
  • HY-100965
    Diphenyleneiodonium chloride Inhibitor 99.87%
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
  • HY-B0166
    L-Ascorbic acid 99.89%
    L-Ascorbic acid is an effective reducing agent and donor antioxidant.
  • HY-D0187
    L-Glutathione reduced 99.83%
    L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
  • HY-17577
    Berberine chloride hydrate Activator 99.56%
    Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
  • HY-101445
    Trolox 99.53%
    Trolox is a vitamin E analogue and is a powerful antioxidant.
  • HY-100168
    BAPTA Inhibitor >98.0%
    BAPTA is a calcium chelator. BAPTA suppresses intracellular reactive oxygen species (ROS) levels.
  • HY-13750
    Ebselen 99.58%
    Ebselen (SPI-1005) is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen can permeate the blood-brain barrier and inhibit inositol monophosphatase (IMPase). Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen inhibits QSOX1 enzymatic activity and has anticancer activity .
  • HY-N0796
    Procyanidin B2 99.40%
    Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.
  • HY-D0937
    Methoxy-PMS 98.14%
    Methoxy-PMS (1-Methoxy PMS; 1-Methoxyphenazine methosulfate) is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.
  • HY-110256
    N-Acetylcysteine amide >99.0%
    N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent, reduces ROS production.
  • HY-B0166A
    L-Ascorbic acid sodium salt >98.0%
    L-Ascorbic acid sodium salt is a more bioavailable form of vitamin C that is an antioxidant agent.
  • HY-N0105
    Rhein >99.0%
    Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.
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