1. Signaling Pathways
  2. PROTAC
  3. SNIPER

SNIPER

Specific and Non-genetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers (SNIPER) is designed to induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins. SNIPER and PROTAC are hybrid molecules composed of two different ligands connected by a linker; one ligand is for a target protein and the other is for E3 ubiquitin ligases. A series of SNIPER(ABL) compounds are synthesized by combination of various inhibitors (e.g. ABL, BRD, AR, ER) and IAP ligands, and the linker is optimized for protein knockdown activity.

SNIPER Related Products (26):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111846
    PROTAC ERα Degrader-2 1351169-29-3 98.02%
    PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
    PROTAC ERα Degrader-2
  • HY-111844
    PROTAC RAR Degrader-1 1351169-27-1
    PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
    PROTAC RAR Degrader-1
  • HY-111872
    SNIPER(ABL)-020
    SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein.
    SNIPER(ABL)-020
  • HY-111841
    PROTAC CRABP-II Degrader-2 1225383-38-9
    PROTAC CRABP-II Degrader-2 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.
    PROTAC CRABP-II Degrader-2
  • HY-111858
    SNIPER(ABL)-050
    SNIPER(ABL)-050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein.
    SNIPER(ABL)-050
  • HY-111861
    SNIPER(ABL)-024 2222355-77-1
    SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM.
    SNIPER(ABL)-024
  • HY-111876
    SNIPER(TACC3)-1
    SNIPER(TACC3)-1 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway. SNIPER(TACC3)-1 induces cancer cell death.
    SNIPER(TACC3)-1
  • HY-122825
    SNIPER(ER)-110
    SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively.
    SNIPER(ER)-110
  • HY-111863
    SNIPER(ABL)-047
    SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 2 μM.
    SNIPER(ABL)-047
  • HY-111842
    PROTAC CRABP-II Degrader-3 1225383-41-4
    PROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.
    PROTAC CRABP-II Degrader-3
  • HY-111862
    SNIPER(ABL)-044
    SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM.
    SNIPER(ABL)-044
  • HY-111875
    SNIPER(BRD)-1 2095244-54-3
    SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.
    SNIPER(BRD)-1
  • HY-111877
    SNIPER(TACC3)-2
    SNIPER(TACC3)-2 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway. SNIPER(TACC3)-2 induces cancer cell death.
    SNIPER(TACC3)-2
  • HY-124847
    SNIPER(ABL)-062 2140260-89-3
    SNIPER(ABL)-062, in which an ABL inhibitor is linked to a ligand of cIAP1 via a linker containing a variable polyethylene glycol (PEG) unit, shows a potent activity to degrade the BCR-ABL protein.
    SNIPER(ABL)-062
  • HY-111840
    PROTAC CRABP-II Degrader-1 1225383-40-3
    PROTAC CRABP-II Degrader-1 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.
    PROTAC CRABP-II Degrader-1
  • HY-111873
    SNIPER(ABL)-019
    SNIPER(ABL)-019, conjugating Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM.
    SNIPER(ABL)-019
  • HY-111848
    PROTAC AR Degrader-4 1351169-31-7
    PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
    PROTAC AR Degrader-4
  • HY-119391
    SNIPER(AR)-51 2113688-43-8
    SNIPER(AR)-51 (AR-51), consists of a cIAP1 ligand and an androgen ligand, connected by a linker. SNIPER(AR)-51 induces androgen receptor (AR) protein degradation.
    SNIPER(AR)-51
  • HY-111859
    SNIPER(ABL)-058 2222354-61-0
    SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM.
    SNIPER(ABL)-058
  • HY-111871
    SNIPER(ABL)-033 2222354-18-7
    SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM.
    SNIPER(ABL)-033
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