Signaling Pathway

Salt-inducible Kinases (SIKs)

Salt-inducible Kinases (SIKs)

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SIKs (Salt-inducible kinases) are a family of related serine-threonine kinases. In cultured adrenocortical cells, SIK1 is rapidly but transiently induced by adrenocorticotropin (ACTH) treatment, suggesting that it contributes to ACTH-mediated induction of steroidogenic enzymes. SIK2 is found in adipocytes and phosphorylates a specific serine residue in insulin receptor substrate-1. Members of the SIK family are emerging as important modulators of key processes such as steroid hormone biosynthesis by the adrenal cortex and insulin signaling in adipocytes.

Salt-inducible Kinases (SIKs) Inhibitors & Modulators (1)

Product Name Catalog No. Brief Description
HG-9-91-01

HY-15776

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.