1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase Inhibitors

Topoisomerase Inhibitors

Topoisomerase

Topo I

Topo II

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Topoisomerase Inhibitors & Agonists
Product Name Topoisomerase Topo I Topo II Purity
Doxorubicin hydrochloride  
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
99.47%
Etoposide    
Topoisomerase II
99.94%
Irinotecan  
Topoisomerase I
  99.84%
SN-38  
Topoisomerase I
  99.46%
Camptothecin  
Topoisomerase I, IC50: 679 nM
  98.62%
Gimatecan  
Topoisomerase I
  98.01%
Epirubicin hydrochloride
Topoisomerase
    99.16%
Topotecan Hydrochloride  
Topoisomerase I
  99.59%
Daunorubicin Hydrochloride    
Topoisomerase II
99.37%
Exatecan Mesylate  
Topoisomerase I, IC50: 2.2 μM
  99.91%
Mitoxantrone    
Topoisomerase II
>98.0%
Irinotecan hydrochloride  
Topoisomerase I
  99.75%
Idarubicin hydrochloride    
Topoisomerase II
99.82%
Dxd  
Topoisomerase I, IC50: 0.31 μM
  98.20%
Aldoxorubicin    
Topoisomerase II
Betulinic acid  
Topoisomerase I, IC50: 5 μM
  >98.0%
β-Lapachone  
Topoisomerase I
  99.72%
Irinotecan hydrochloride trihydrate  
Topoisomerase I
  99.78%
Teniposide    
Topoisomerase II
99.43%
Amsacrine    
Topoisomerase II
99.98%
Pirarubicin    
Topoisomerase II
99.61%
Mitoxantrone dihydrochloride    
Topoisomerase II
98.01%
Bisantrene    
Topoisomerase II
95.44%
Daun02
Topoisomerase
    98.05%
Hycanthone  
Topoisomerase I
Topoisomerase II
98.85%
Pirarubicin Hydrochloride    
Topoisomerase II
98.51%
Ellipticine hydrochloride    
Topoisomerase II
99.34%
Gatifloxacin    
Topoisomerase II, IC50: 36.7 μM
99.37%
Genz-644282  
Topoisomerase I
  98.03%
(S)-10-Hydroxycamptothecin  
Topoisomerase I
  99.38%
Nalidixic acid
Topoisomerase
    99.99%
Pixantrone dimaleate    
Topoisomerase II
>97.0%
Voreloxin Hydrochloride    
Topoisomerase II
99.96%
Belotecan hydrochloride  
Top1
  98.82%
Proscillaridin A  
Topoisomerase I, IC50: 30 nM
Topoisomerase II, IC50: 100 nM
99.74%
Aurintricarboxylic acid    
Topoisomerase II
Karenitecin  
Topoisomerase I
  98.30%
TAS-103 dihydrochloride  
Topoisomerase I
Topoisomerase II
99.70%
9-amino-CPT  
Topoisomerase I
  98.89%
Namitecan  
Topoisomerase I
  98.11%
Chloroquinoxaline sulfonamide    
topoisomerase II alpha
topoisomerase II beta
99.47%
Amonafide    
Topoisomerase II
99.92%
Amsacrine hydrochloride    
Topoisomerase II
98.98%
LMP744 hydrochloride  
Top1
  99.21%
Gatifloxacin hydrochloride    
Topoisomerase II, : 36.7 μM
>98.0%
Flumequine    
Topoisomerase II, IC50: 15 μM
99.53%
Groenlandicine  
Topoisomerase I
  99.43%
SW044248  
Topoisomerase I
  99.60%
Topotecan  
Topoisomerase I
 
CH-0793076  
Topoisomerase I, IC50: 2.3 μM
 
Ellipticine    
Topoisomerase II
Edotecarin  
Topoisomerase I, IC50: 50 nM
  98.39%
(±)-10-Hydroxycamptothecin  
Topoisomerase I
 
CH-0793076 TFA  
Topoisomerase I, IC50: 2.3 μM
  98.26%
Pixantrone    
Topoisomerase II
Exatecan  
Topoisomerase I, IC50: 2.2 μM
 
Daunorubicin    
Topoisomerase II
TAS-103  
Topoisomerase I
Topoisomerase II
MC-DOXHZN    
Topoisomerase II
Etoposide phosphate disodium    
Topoisomerase II
Etoposide phosphate    
Topoisomerase II
98.40%
Gatifloxacin sesquihydrate    
Topoisomerase II, IC50: 36.7 μM
Rebeccamycin  
Topoisomerase I
 
T-2513  
Topoisomerase I
 
Nalidixic acid sodium salt
Topoisomerase
   
MC-DOXHZN hydrochloride    
Topoisomerase II
Exatecan D5 Mesylate  
Topoisomerase I, IC50: 0.975 μg/mL
 
Zabofloxacin  
Topoisomerase I
Topoisomerase II
Gatifloxacin mesylate    
Topoisomerase II, IC50: 36.7 μM
Voreloxin    
Topoisomerase II
Intoplicine  
Topoisomerase I
Topoisomerase II
Epirubicin
Topoisomerase
   
9-Hydroxyellipticine hydrochloride    
Topoisomerase II