1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR Inhibitors

mGluR Inhibitors

mGluR1

mGluR2

mGluR3

mGluR4

mGluR5

mGluR6

mGluR7

mGluR8

mGluR

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

mGluR Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR Purity
L-Glutamine                
mGluR
>98.0%
LY341495
mGluR1a, IC50: 7.8 μM
mGluR2, IC50: 21 nM
mGluR3, IC50: 14 nM
mGluR4, IC50: 22 μM
mGluR5a, IC50: 8.2 μM
 
mGluR7, IC50: 990 nM
mGluR8, IC50: 170 nM
  99.11%
Eglumegad  
mGluR2R, IC50: 5 nM
mGluR3R, IC50: 24 nM
            >98.0%
DHPG
mGluR 1
     
mGluR 5
        99.31%
MPEP Hydrochloride        
mGluR5, IC50: 36 nM
        99.69%
CDPPB        
mGluR5, EC50: 27 nM
        98.05%
AZD 2066 hydrate        
mGluR5
        >99.0%
Pomaglumetad methionil hydrochloride  
mGluR2
mGluR3
            98.20%
Xanthurenic acid  
mGluR2
mGluR3
            98.17%
MTEP hydrochloride        
mGluR5, IC50: 5 nM
mGluR5, Ki: 16 nM
        99.71%
trans-ACPD                
mGluR
>98.0%
Lu AF21934      
mGlu4 Receptor, EC50: 500 nM
          99.27%
Mavoglurant        
mGluR5, IC50: 30 nM
        99.99%
VU0650786    
mGluR3, IC50: 392 nM
            99.97%
JNJ16259685
mGluR1, IC50: 19 nM
                98.85%
Foliglurax monohydrochloride      
mGlu4, EC50: 79 nM
          98.93%
CTEP        
mGlu5 Receptor, IC50: 2.2 nM
        99.43%
Dipraglurant        
mGluR5, IC50: 21 nM
        99.99%
Basimglurant        
mGlu5 Receptor, Kd: 1.1 nM
        99.56%
VU6012962            
mGlu7, IC50: 347 nM
    99.92%
JNJ-46778212        
mGlu5 Receptor, EC50: 260 nM
        99.24%
(S)-MCPG                
mGluR
98.80%
L-Cysteinesulfinic acid monohydrate
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
  99.30%
ADX88178      
mGluR4, EC50: 4 nM
          99.60%
FITM
mGlu1, Ki: 2.5 nM
                98.19%
CPPHA        
mGlu5 Receptor
        95.01%
LY2794193  
mGluR2, EC50: 47.5
mGluR2, Ki: 412
mGluR3, EC50: 0.47 nM
mGluR3, Ki: 0.927 nM
            99.88%
PHCCC                
Group I mGluR receptors, IC50: 3 μM
99.96%
VU0364770      
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
mGlu5, EC50: 17.9 μM
mGlu6, EC50: 6.8 μM
      99.57%
LY404039  
mGlu2 Receptor, Ki: 149 nM (Recombinant human mGluR2)
hmGluR3, Ki: 92 nM
            >98.0%
JNJ-40411813  
mGlu2 Receptor, EC50: 147 nM
              99.69%
L-APB      
mGlu4, EC50: 0.13 μM
 
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
mGlu8, EC50: 0.29 μM
  >99.0%
CHPG        
mGlu5
        >99.0%
Fenobam        
rat mGluR5, Kd: 54 nM
human mGluR5, Kd: 31 nM
        >99.0%
Ro 67-7476
mGluR1a, EC50: 60.1 nM
                99.80%
O-Phospho-L-serine
mGluR1
mGluR2
 
mGluR4
 
mGluR6
mGluR7
mGluR8
  >98.0%
VU0361737      
Human mGlu4, EC50: 240 nM
Rat mGlu4, EC50: 110 nM
          99.83%
E4CPG                
mGluR
>98.0%
VU 0357121        
mGlu5 Receptor, EC50: 33 nM
        99.85%
AZD-8529  
mGluR2, EC50: 285 nM
              98.43%
LY367385
mGluR1a, IC50: 8.8 μM
                >99.0%
JNJ-46281222  
mGluR2, Kd: 1.7 nM
              98.79%
JNJ-42153605  
mGluR2, EC50: 17 nM
              99.00%
ADX-47273        
mGluR5, EC50: 0.17 μM
        99.34%
LY2979165  
mGlu2 Receptor
              >98.0%
mGluR2 antagonist 1  
mGluR2, IC50: 9 nM
              99.06%
FPTQ
Human mGluR1, IC50: 6 nM
Mouse mGluR1, IC50: 1.4 nM
                99.91%
Decoglurant  
mGluR2
mGluR3
            99.71%
(R)-ADX-47273        
mGlu5, EC50: 168 nM
        99.25%
(S)-3,5-DHPG
mGluR1a, Ki: 0.9 μM
     
mGluR5a, Ki: 3.9 μM
        >99.0%
L-Cysteinesulfinic acid
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
 
LY2812223  
mGluR2, Ki: 144 nM
mGluR3, Ki: 156 nM
            >98.0%
AZD 2066        
mGluR5
        >99.0%
VU6005649            
mGlu7 Receptor, EC50: 0.65 μM
mGlu8 Receptor, EC50: 2.6 μM
  98.67%
TCN238      
mGlu4 Receptor, EC50: 1 μM
          98.31%
Mavoglurant racemate        
mGluR5
        98.88%
Methoxy-PEPy        
mGlu5 Receptor, IC50: 1 nM
        98.19%
VU 0364439      
mGlu4 Receptor, EC50: 19.8 nM
          98.01%
CHPG sodium salt        
mGlu5
       
(1R,2S)-VU0155041      
mGluR4
          >98.0%
AZD-8529 mesylate  
mGluR2, EC50: 285 nM
              99.05%
Auglurant        
rat mGluR5, IC50: 11 nM
human mGluR5, IC50: 14 nM
        99.40%
CFMTI
Human mGluR1a, IC50: 2.6 nM
Rat mGluR1a, IC50: 2.3 nM
                >98.0%
CPPG                
group II mGlu receptors, IC50: 46.2 nM
group III mGlu receptors, IC50: 2.2 nM
Quisqualic acid
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
 
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
         
Oxomemazine
mGluR 1, Ki: 84 nM
mGluR2, Ki: 1.65 μM
             
VU0155041      
Human mGlu4, EC50: 798 nM
Rat mGlu4, EC50: 693 nM
         
DCG-IV
mGluR1R, IC50: 389 μM
mGluR2R, EC50: 0.35 μM
mGluR3R, EC50: 0.09 μM
mGluR4R, IC50: 22.5 μM
mGluR5, IC50: 630 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR8, IC50: 32 μM
 
ADX71743            
mGlu7
   
(RS)-PPG      
hmGluR4a, EC50: 5.2 μM
 
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
hmGluR8a, EC50: 0.2 μM
 
LY3020371  
hmGluR2, Ki: 5.26 nM
hmGluR3, Ki: 2.50 nM
           
EGLU  
mGluR2, Kd: 66 μM
             
VU-29
rat mGluR1, EC50: 557 nM
rat mGluR2, EC50: 1.5 μM
 
hmGluR4, EC50: 154 nM
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
        98.04%
MSOP    
mGluR3, Kd: 51 μM
           
Biphenylindanone A  
mGluR2
              >99.0%
VU0364770 hydrochloride      
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
mGlu5, EC50: 17.9 μM
mGlu6, EC50: 6.8 μM
      99.82%
LY 541850  
mGluR2, IC50: 0.161 μM
mGluR3, IC50: 1.05 μM
           
Pomaglumetad methionil anhydrous  
mGluR2
mGluR3
           
cis-ACPD  
mGluR2, EC50: 13 μM
 
mGluR4, EC50: 50 μM
         
YM-298198 hydrochloride
mGluR 1
               
(2R,4R)-APDC                
group II mGlu receptors
NPEC-caged-LY379268                
group II mGlu receptors
Cinnabarinic acid      
mGluR4
         
DFMTI
mGluR1
                99.32%
MPEP        
mGluR5, IC50: 36 nM
       
BMT-145027        
mGluR5, EC50: 47 nM
        98.19%