1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR Inhibitors

mGluR Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

mGluR Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR8 mGluR6 mGluR7 mGluR5 mGluR4 mGluR3 mGluR2 mGluR1 mGluR Purity
L-Glutamine                
mGluR
>98.0%
LY341495
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR5a, IC50: 8.2 μM
mGluR4, IC50: 22 μM
mGluR3, IC50: 14 nM
mGluR2, IC50: 21 nM
mGluR1a, IC50: 7.8 μM
  99.11%
Eglumegad          
mGluR3R, IC50: 24 nM
mGluR2R, IC50: 5 nM
    >98.0%
DHPG      
mGluR 5
     
mGluR 1
  >97.0%
MPEP Hydrochloride      
mGluR5, IC50: 36 nM
          99.69%
L-Cysteinesulfinic acid monohydrate
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
 
mGluR2 antagonist 1            
mGluR2, IC50: 9 nM
    99.06%
AZD 2066 hydrate      
mGluR5
          >99.0%
Xanthurenic acid          
mGluR3
mGluR2
    98.17%
trans-ACPD                
mGluR
>98.0%
Lu AF21934        
mGlu4 Receptor, EC50: 500 nM
        99.27%
MTEP hydrochloride      
mGluR5, IC50: 5 nM
mGluR5, Ki: 16 nM
          99.71%
JNJ16259685              
mGluR1, IC50: 19 nM
  98.85%
Mavoglurant      
mGluR5, IC50: 30 nM
          99.99%
Foliglurax monohydrochloride        
mGlu4, EC50: 79 nM
        98.93%
CTEP      
mGlu5 Receptor, IC50: 2.2 nM
          99.43%
FITM              
mGlu1, Ki: 2.5 nM
  98.19%
JNJ-46778212      
mGlu5 Receptor, EC50: 260 nM
          99.24%
VU0650786          
mGluR3, IC50: 392 nM
      99.97%
(S)-MCPG                
mGluR
98.80%
VU0364770  
mGlu6, EC50: 6.8 μM
 
mGlu5, EC50: 17.9 μM
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
        99.57%
ADX88178        
mGluR4, EC50: 4 nM
        99.60%
CPPHA      
mGlu5 Receptor
          95.01%
LY2794193          
mGluR3, EC50: 0.47 nM
mGluR3, Ki: 0.927 nM
mGluR2, EC50: 47.5
mGluR2, Ki: 412
    99.88%
L-APB
mGlu8, EC50: 0.29 μM
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
 
mGlu4, EC50: 0.13 μM
        >99.0%
Dipraglurant      
mGluR5, IC50: 21 nM
          99.99%
Basimglurant      
mGlu5 Receptor, Kd: 1.1 nM
          99.56%
JNJ-40411813            
mGlu2 Receptor, EC50: 147 nM
    99.69%
VU6012962    
mGlu7, IC50: 347 nM
            99.92%
PHCCC                
Group I mGluR receptors, IC50: 3 μM
99.96%
O-Phospho-L-serine
mGluR8
mGluR6
mGluR7
 
mGluR4
 
mGluR2
mGluR1
  >98.0%
VU0361737        
Human mGlu4, EC50: 240 nM
Rat mGlu4, EC50: 110 nM
        99.83%
E4CPG                
mGluR
>98.0%
LY404039          
hmGluR3, Ki: 92 nM
mGlu2 Receptor, Ki: 149 nM (Recombinant human mGluR2)
    >98.0%
VU 0357121      
mGlu5 Receptor, EC50: 33 nM
          99.85%
AZD-8529            
mGluR2, EC50: 285 nM
    98.43%
JNJ-46281222            
mGluR2, Kd: 1.7 nM
    98.79%
Fenobam      
rat mGluR5, Kd: 54 nM
human mGluR5, Kd: 31 nM
          >99.0%
Ro 67-7476              
mGluR1a, EC50: 60.1 nM
  99.80%
VU6005649
mGlu8 Receptor, EC50: 2.6 μM
 
mGlu7 Receptor, EC50: 0.65 μM
            98.67%
JNJ-42153605            
mGluR2, EC50: 17 nM
    99.00%
LY2979165            
mGlu2 Receptor
    >98.0%
CHPG      
mGlu5
          >99.0%
FPTQ              
Human mGluR1, IC50: 6 nM
Mouse mGluR1, IC50: 1.4 nM
  99.91%
Decoglurant          
mGluR3
mGluR2
    99.71%
(R)-ADX-47273      
mGlu5, EC50: 168 nM
          99.25%
L-Cysteinesulfinic acid
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
 
LY2812223          
mGluR3, Ki: 156 nM
mGluR2, Ki: 144 nM
    >98.0%
AZD 2066      
mGluR5
          >99.0%
TCN238        
mGlu4 Receptor, EC50: 1 μM
        98.31%
Mavoglurant racemate      
mGluR5
          98.88%
ADX-47273      
mGluR5, EC50: 0.17 μM
          99.34%
Methoxy-PEPy      
mGlu5 Receptor, IC50: 1 nM
          98.19%
VU 0364439        
mGlu4 Receptor, EC50: 19.8 nM
        98.01%
CHPG sodium salt      
mGlu5
         
AZD-8529 mesylate            
mGluR2, EC50: 285 nM
    99.05%
Auglurant      
rat mGluR5, IC50: 11 nM
human mGluR5, IC50: 14 nM
          99.40%
CFMTI              
Human mGluR1a, IC50: 2.6 nM
Rat mGluR1a, IC50: 2.3 nM
  >98.0%
CPPG                
group II mGlu receptors, IC50: 46.2 nM
group III mGlu receptors, IC50: 2.2 nM
Quisqualic acid        
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
 
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
 
Oxomemazine            
mGluR2, Ki: 1.65 μM
mGluR 1, Ki: 84 nM
 
LY367385              
mGluR1a, IC50: 8.8 μM
  >99.0%
VU0155041        
Human mGlu4, EC50: 798 nM
Rat mGlu4, EC50: 693 nM
       
(S)-3,5-DHPG      
mGluR5a, Ki: 3.9 μM
     
mGluR1a, Ki: 0.9 μM
 
DCG-IV
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR5, IC50: 630 μM
mGluR4R, IC50: 22.5 μM
mGluR3R, EC50: 0.09 μM
mGluR2R, EC50: 0.35 μM
mGluR1R, IC50: 389 μM
 
ADX71743    
mGlu7
           
(RS)-PPG
hmGluR8a, EC50: 0.2 μM
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
 
hmGluR4a, EC50: 5.2 μM
       
LY3020371          
hmGluR3, Ki: 2.50 nM
hmGluR2, Ki: 5.26 nM
   
VU-29      
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
hmGluR4, EC50: 154 nM
 
rat mGluR2, EC50: 1.5 μM
rat mGluR1, EC50: 557 nM
 
MSOP          
mGluR3, Kd: 51 μM
     
Biphenylindanone A            
mGluR2
    >99.0%
VU0364770 hydrochloride  
mGlu6, EC50: 6.8 μM
 
mGlu5, EC50: 17.9 μM
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
        99.82%
LY 541850          
mGluR3, IC50: 1.05 μM
mGluR2, IC50: 0.161 μM
   
LY2140023          
mGluR3
mGluR2
   
cis-ACPD        
mGluR4, EC50: 50 μM
 
mGluR2, EC50: 13 μM
   
YM-298198 hydrochloride              
mGluR 1
 
CDPPB      
mGluR5, EC50: 27 nM
         
(2R,4R)-APDC                
group II mGlu receptors
NPEC-caged-LY379268                
group II mGlu receptors
Cinnabarinic acid        
mGluR4
       
DFMTI              
mGluR1
  99.32%
MPEP      
mGluR5, IC50: 36 nM
         
BMT-145027      
mGluR5, EC50: 47 nM
          98.19%