1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38 MAPK Inhibitors

p38 MAPK Inhibitors

p38 MAPK

p38α

p38β

MAPK13

p38δ

p38γ

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

p38 MAPK Inhibitors & Activators
Product Name p38 MAPK p38α p38β MAPK13 p38δ p38γ Purity
SB 203580
p38, IC50: 50 nM
 
p38β2, IC50: 500 nM
      99.92%
SB 202190  
p38α, IC50: 50 nM
p38β2, IC50: 100 nM
      99.89%
Doramapimod
p38 MAP kinase, Kd: 0.1 nM
p38α, IC50: 38 nM
p38β, IC50: 65 nM
 
p38δ, IC50: 520 nM
p38γ, IC50: 200 nM
99.88%
Ralimetinib  
p38α MAPK, IC50: 5.3 nM
p38β MAPK, IC50: 3.2 nM
     
p38α inhibitor 2  
p38α MAPK, pIC50: 9.6
        98.97%
Ralimetinib dimesylate  
p38α MAPK, IC50: 5.3 nM
p38β MAPK, IC50: 3.2 nM
      99.52%
SB 203580 hydrochloride
p38, IC50: 50 nM
 
p38β2, IC50: 500 nM
      99.71%
TAK-715  
p38α, IC50: 7.1 nM
p38β, IC50: 200 nM
 
p38δ, IC50: >10 μM
p38γ, IC50: >10 μM
99.89%
Neflamapimod  
p38α, IC50: 10 nM
p38β, IC50: 220 nM
      ≥98.0%
Talmapimod  
p38α, IC50: 9 nM
p38β, IC50: 90 nM
      98.73%
Pamapimod  
p38α, IC50: 14 nM
p38α, Ki: 1.3 nM
p38β, IC50: 480
p38β, Ki: 120 nM
      99.92%
MAPK13-IN-1      
MAPK13 (p38δ), IC50: 620 nM
    98.47%
Skatole
p38
          ≥98.0%
BMS-582949 hydrochloride  
p38α MAPK, IC50: 13 nM
        98.82%
MW-150  
p38α, Ki: 101 nM
        99.90%
R1487 Hydrochloride  
p38α, Kd: 0.2 nM
p38β, Kd: 29 nM
      98.94%
Semapimod tetrahydrochloride
p38 MAPK
          ≥97.0%
p38α inhibitor 1  
p38α
        98.70%
Ferulic acid methyl ester
p38
          99.18%
p38 MAPK-IN-1
p38 MAPK, IC50: 68 nM
          98.91%
SD-169  
p38α MAPK, IC50: 3.2 nM
p38β MAPK, IC50: 122 nM
      99.44%
UM-164  
p38α
p38β
      99.08%
Dihydrocaffeic acid
p38 MAPK
          ≥98.0%
Paris saponin VII
p38
          ≥99.0%
RWJ-67657  
p38α, IC50: 1 μM
p38β, IC50: 11 μM
      ≥98.0%
Gossypetin
p38 MAP kinase
          99.82%
AMG-548 dihydrochloride  
p38α, Ki: 0.5 nM
dog p38α, Ki: 5.0 nM
p38β, Ki: 3.6 nM
 
p38δ, Ki: 2600 nM
p38γ, Ki: 4100 nM
≥98.0%
SR-318  
p38α, IC50: 5 nM
p38β, IC50: 32 nM
      98.87%
TA-01
p38 MAP kinase, IC50: 6.7 nM
          99.93%
Esculin
p38 MAPK
          99.97%
N-​Feruloyloctopamine
p38 MAPK
          98.49%
AL 8697  
p38α, IC50: 6 nM
p38β, IC50: 82 nM
      ≥99.0%
Rotundic acid
p38 MAPK
          ≥99.0%
AMG-548  
p38α, Ki: 0.5 nM
dog p38α, Ki: 5.0 nM
p38β, Ki: 3.6 nM
 
p38δ, Ki: 2600 nM
p38γ, Ki: 4100 nM
≥99.0%
Isoliquiritin apioside
p38 MAPK
          99.87%
SJFδ  
p38α, DC50: 46.17 nM
       
MW-150 hydrochloride  
p38α, Ki: 101 nM
       
MW-150 dihydrochloride dihydrate  
p38α, Ki: 101 nM
       
PF-03715455  
p38α, IC50: 0.88 nM
p38β, IC50: 23 nM
     
Talmapimod hydrochloride  
p38α, IC50: 9 nM
p38β, IC50: 90 nM
     
SJFα  
p38α, DC50: 7.16 nM
   
p38δ, DC50: 299 nM
 
MKK7-COV-9
p38 MAP kinase
         
EW-7195  
p38α, IC50: 1.5 μM
       
Cornuside
p38 MAP kinase