1. Metabolic Enzyme/Protease
  2. Phosphatase

Tautomycin 

Cat. No.: HY-12728 Purity: >98.0%
Handling Instructions

Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.

For research use only. We do not sell to patients.

Tautomycin Chemical Structure

Tautomycin Chemical Structure

CAS No. : 109946-35-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively[1][2].

IC50 & Target

Kiapp: 0.16 nM (PP1), 0.4 nM (PP2A)[1].

In Vitro

MTC cell growth is inhibited in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].
NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].

Cell Proliferation Assay[2]

Cell Line: Human MTC cells
Concentration: 0-1000 nM
Incubation Time: 48 hours
Result: Inhibited MTC cell growth in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: Human MTC cells
Concentration: 0-1000 nM
Incubation Time: 48 hours
Result: Led to a dose-dependent decrease in the NE markers ASCL1 and CgA.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3038 mL 6.5192 mL 13.0385 mL
5 mM 0.2608 mL 1.3038 mL 2.6077 mL
10 mM 0.1304 mL 0.6519 mL 1.3038 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

766.96

Formula

C₄₁H₆₆O₁₃

CAS No.

109946-35-2

SMILES

C[[email protected]@H]([[email protected]]([[email protected]](CC1)C)([H])O[[email protected]@]1(CC[[email protected]]2C)O[[email protected]]2CC[[email protected]](C)C(C)=O)CC[[email protected]](O)[[email protected]](C)C(C[[email protected]@H](O)[[email protected]](OC)[[email protected]@H](C(C)C)OC(C[[email protected]](C(C(O3)=O)=C(C3=O)C)O)=O)=O

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Tautomycin
Cat. No.:
HY-12728
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Tautomycin

Cat. No.: HY-12728