1. Metabolic Enzyme/Protease
  2. Phosphatase

Tautomycin 

Cat. No.: HY-12728 Purity: >98.0%
Handling Instructions

Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.

For research use only. We do not sell to patients.

Tautomycin Chemical Structure

Tautomycin Chemical Structure

CAS No. : 109946-35-2

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25 μg USD 490 In-stock
Estimated Time of Arrival: December 31

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Description

Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively[1][2].

IC50 & Target

Kiapp: 0.16 nM (PP1), 0.4 nM (PP2A)[1].

In Vitro

MTC cell growth is inhibited in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].
NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].

Cell Proliferation Assay[2]

Cell Line: Human MTC cells
Concentration: 0-1000 nM
Incubation Time: 48 hours
Result: Inhibited MTC cell growth in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: Human MTC cells
Concentration: 0-1000 nM
Incubation Time: 48 hours
Result: Led to a dose-dependent decrease in the NE markers ASCL1 and CgA.
References
Molecular Weight

766.96

Formula

C₄₁H₆₆O₁₃

CAS No.

109946-35-2

SMILES
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Tautomycin
Cat. No.:
HY-12728
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Tautomycin

Cat. No.: HY-12728