1. Cytoskeleton
  2. Integrin
  3. ICAM-1-IN-1

ICAM-1-IN-1 

Cat. No.: HY-U00003 Purity: 99.96%
Handling Instructions

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.

For research use only. We do not sell to patients.

ICAM-1-IN-1 Chemical Structure

ICAM-1-IN-1 Chemical Structure

CAS No. : 251994-14-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 550 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 550 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.

IC50 & Target

IC50: 7 nM (E-selectin), 5 nM (ICAM-1)[1]

In Vivo

ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.23

Formula

C15H11BrN2O2S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 135 mg/mL (371.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7531 mL 13.7654 mL 27.5308 mL
5 mM 0.5506 mL 2.7531 mL 5.5062 mL
10 mM 0.2753 mL 1.3765 mL 2.7531 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (6.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (6.19 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (6.19 mM); Clear solution

*All of the co-solvents are available by MCE.
References
Animal Administration
[1]

Rats: In a rat rheumatoid arthritis model, 26 all rats are treated with peptidoglycan polysaccharide to elicit the disease to a desired degree. Six rats per group are then treated with ICAM-1-IN-1 or vehicle control twice daily. The ankles of these rats are measured on day 0, 1, 3, 7, 9, 11, 16, 18, and 21 after administration. Histologic analyses of the ankles are performed on the last day of the experiment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.96%

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ICAM-1-IN-1
Cat. No.:
HY-U00003
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