UM171

Cat. No.: HY-12878 Purity: 98.14%: FAQs
Data Sheet SDS COA Handling Instructions

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UM171 is a selective agonist of human hematopoietic stem cell self-renewal. UM171 binds to hematopoietic cytokines and has the ability to promote the maintenance and expansion of human primary HSCs in vitro. UM171 can be used in the study of hematopoietic derivation of human pluripotent stem cells in vitro.

For research use only. We do not sell to patients.

UM171 Chemical Structure

CAS No. : 1448724-09-1

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 132	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 216	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 408	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 732	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1320	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

In Vitro

UM171 (50-100 nM) significantly increases CD34⁺ CD43⁺ and CD34⁺ CD45⁺ hematopoietic progenitors. UM171 enhances the derivation of hematopoietic cells at multiple developmental steps. UM171 enhances de novo generation of hematopoietic progenitor cells from hPSCs at multiple phases during hematopoietic differentiation in vitro. UM171 shows no effect on erythroid development, but inhibits erythroid maturation^[1]. UM171 treatment enhances the engraftment potential of CD34⁺ macaque cells by threefold. UM171 attenuates cell differentiation and promotes ex vivo expansion of primitive human hematopoietic cells, and promotes expansion of LT-HSCs. UM171 treatment results in down-regulation of AhR target genes such as CYP1B1, CYP1A1, and AhRR^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

453.54

Formula

C₂₅H₂₇N₉

CAS No.

1448724-09-1

Appearance

Solid

Color

Off-white to yellow

SMILES

N[C@H]1CC[C@H](NC2=C3C(NC4=C3C=CC(C5=NN(C)N=N5)=C4)=NC(CC6=CC=CC=C6)=N2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 75 mg/mL (165.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2049 mL	11.0244 mL	22.0488 mL
5 mM	0.4410 mL	2.2049 mL	4.4098 mL
10 mM	0.2205 mL	1.1024 mL	2.2049 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.14%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (253 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2049 mL	11.0244 mL	22.0488 mL	55.1219 mL
	5 mM	0.4410 mL	2.2049 mL	4.4098 mL	11.0244 mL
	10 mM	0.2205 mL	1.1024 mL	2.2049 mL	5.5122 mL
	15 mM	0.1470 mL	0.7350 mL	1.4699 mL	3.6748 mL
	20 mM	0.1102 mL	0.5512 mL	1.1024 mL	2.7561 mL
	25 mM	0.0882 mL	0.4410 mL	0.8820 mL	2.2049 mL
	30 mM	0.0735 mL	0.3675 mL	0.7350 mL	1.8374 mL
	40 mM	0.0551 mL	0.2756 mL	0.5512 mL	1.3780 mL
	50 mM	0.0441 mL	0.2205 mL	0.4410 mL	1.1024 mL
	60 mM	0.0367 mL	0.1837 mL	0.3675 mL	0.9187 mL
	80 mM	0.0276 mL	0.1378 mL	0.2756 mL	0.6890 mL
	100 mM	0.0220 mL	0.1102 mL	0.2205 mL	0.5512 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UM1711448724-09-1UM 171UM-171Inhibitorinhibitorinhibit

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